Alterations in serum electrolyte levels after dimethoate exposure and recovery in the freshwater air-breathing catfish<i>, Heteropneustes fossilis</i>(Bloch)

Das, Vijai Krishna; Malviya, Avinash; Pandey, Rakesh

doi:10.1080/02772248.2013.856913

Cited by 5 publications

(8 citation statements)

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“…A progressive decrease in serum calcium level was observed in Heteropneustes fossilis after 48 h (short term) and 7 d (long term) exposure to Euphorbia royleana latex [24]. Das et al have reported hypocalcemia in Heteropneustes fossilis after dimethoate exposure [11].…”

Section: Discussionmentioning

confidence: 99%

“…Fish are in intimate contact with their environment through gills; therefore, activity of CS is influenced by several external and internal factors. Environmental contaminants adversely affect the gills [4][5][6] and therefore, disrupt entire mechanism of electrolyte regulation in fish [7][8][9][10][11]. Exposure of pesticides adversely affects the function of CS and calcium homeostasis in fish [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

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Dimethoate Induced Changes in Serum Ca2+ and Corpuscles of Stannius in Freshwater Catfish Heteropneustes fossilis, after Short-Term and Long-Term Exposure

Pandey¹

2015

AJLS

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The Corpuscles of Stannius (CS) exclusively present in bony fishes, produce Stanniocalcin-an antihypercalcemic hormone. Fish are in intimate contact with their surrounding through their gills. Gills are the main target of stanniocalcin; therefore, the activity of CS is influenced by many external and internal factors. Stressful conditions such as exposure to various pesticides disturb the ionic balance in fishes. Short-term (96 h) and long-term (36 d) toxic effect of an organophosphate insecticide, dimethoate was studied on serum Ca 2+ and CS histology in freshwater air-breathing catfish Heteropneustes fossilis. The concentration of dimethoate for short-term exposure was 2.24 mg L-1 (75% of 96 h LC 50) and for long-term was 0.75 mg L-1 (25% of 96 h LC 50). Fish exhibited hypocalcaemia in both the short-term as well as in long-term experiment. The glandular cells of CS in short-term experiment, exhibited increase in the nuclear volume (NV) along with increase in the nucleoli number after 24 h and thereafter, show decrease in NV and deformity of nucleus after 96 h dimethoate exposure. In long-term experiment, the NV increased following 6 d of exposure to dimethoate, but decreased significantly thereafter. The gland exhibited degeneration after 36 d of dimethoate exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dimethoate Induced Changes in Serum Ca2+ and Corpuscles of Stannius in Freshwater Catfish Heteropneustes fossilis, after Short-Term and Long-Term Exposure

Pandey¹

2015

AJLS

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“…Dimethoate (C5H12NO3PS2, CAS NO 60-51-5) is an organophosphate pesticide widely used in agriculture to control broad range of insects. The mode of action is phosphorylation of serine residues of the active site of acetylcholinesterase (AChE), which results to inhibition of AChE [6,7] and subsequent overstimulation of effector organs by acetylcholine. Ultimately, nervous system failure, impairment of the respiratory myocardial and neuromuscular transmissions and death occur [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

“…On uptake, the pesticides may be bio transformed, metabolized and then eliminated or bioaccumulated [5]. Bioaccumulated pesticides could damage some vital organs in the fish [15,20] and cause severe ecological damages [6]. Furthermore, metabolism of most pesticides and xenobiotics in fish results in the production of reactive oxygen species (ROS) [1,4,21].…”

Section: Introductionmentioning

confidence: 99%

Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus

Okogwu¹,

Elebe²,

Nwonumara³

2022

Environ Anal Health Toxicol

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Cypermethrin and dimethoate are pesticides frequently used in agriculture to eliminate pests. Contemporaneity of these and other pesticides in commercial preparations and several aquatic ecosystems is well known, though poorly studied. This study aims to evaluate the effect of sublethal concentrations of combinations of cypermethrin and dimethoate on juvenile catfish, Clarias gariepinus, given that the pesticides concomitantly occur in the floodplains were the fish breed. Behavioral, hematological and histopathological changes in juvenile fish exposed to sublethal concentrations were monitored for 96 hours. Pesticide exposed fish exhibited abnormal behaviors such as erratic swimming, frequent air gulping, sudden jerk movement and rapid opercula movement and these were more pronounced in higher concentrations. Significant reductions in erythrocytes (0.83-20.94%), hemoglobin (4.12-29.23%) and PVC (7.14-28.57%) and increase in leucocytes (4.84-9.32%) were observed (p<0.05). Mean corpuscular hemoglobin concentration (MCHC), mean corpuscular hemoglobin (MCH) and mean cell volume (MCV) reduced significantly in the exposed groups compared to the control. Infiltration of inflammatory cells, distortion of cell architecture, hemorrhage and necrosis were the observed histopathological damages in the heart, brain, gill, liver, kidney and fin of exposed fish. These pathological damages were more severe than previously reported for either chemical. Therefore, the use of these chemicals in agriculture should be regulated, especially near fish breeding sites.

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“…Adverse effects of pesticide on fish have been studied by many workers [1,2,3]. The pesticides cause disruption in calcium regulating endocrine glands and other vital organs of the fish [1,2,3,4,5].…”

Section: Introductionmentioning

confidence: 99%

Histological Changes in Calcium Regulating Endocrine Gland (Ultimobranchial) After Dimethoate Exposure in Freshwater Catfish <i>Heteropneustes Fossilis</i>

Pandey¹

2015

BIO

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Ultimobranchial gland in fishes is associated primarily with calcium regulation. The study was aimed to find effect of an organophosphate pesticide dimethoate on serum Ca 2+ and ultimobranchial gland in freshwater catfish Heteropneustes fossilis. Fish were exposed to dimethoate at 2.24 mg/l (75% of 96 h LC 50) for short-term (24, 48, 72 and 96 h), and 25% of 96 h LC 50 (1.00 mg/l) for long-term (6, 12, 24 and 36 d). The blood samples collected at assigned durations from the anaesthetized fish were used to measure serum Ca 2+ levels. At the same time UBG were also extricated from the fish by removing the tissues adjoining esophagus, liver and sinus venosus of the heart for subsequent histological examination. A significant (P<0.05) increase in serum Ca 2+ levels of fish following 24 h and 6d dimethoate exposure was observed. However, after 48 h and 12 d the Ca 2+ level gradually begins to decline exhibiting significant (P<0.0001) hypocalcaemia after 96 h and 36 d in the exposed fishes. The histological examination of exposed fish glands exhibit significant changes in their cellular activity, staining property, nuclear diameter and nuclear volume, vacuolization and degeneration. It is concluded that dimethoate severely hampers the calcium homeostasis in Heteropneustes fossilis; therefore the pesticide should be cautiously used near aquatic bodies.

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Alterations in serum electrolyte levels after dimethoate exposure and recovery in the freshwater air-breathing catfish, Heteropneustes fossilis(Bloch)

Cited by 5 publications

References 17 publications

Dimethoate Induced Changes in Serum Ca2+ and Corpuscles of Stannius in Freshwater Catfish Heteropneustes fossilis, after Short-Term and Long-Term Exposure

Dimethoate Induced Changes in Serum Ca2+ and Corpuscles of Stannius in Freshwater Catfish Heteropneustes fossilis, after Short-Term and Long-Term Exposure

Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus

Histological Changes in Calcium Regulating Endocrine Gland (Ultimobranchial) After Dimethoate Exposure in Freshwater Catfish <i>Heteropneustes Fossilis</i>

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Alterations in serum electrolyte levels after dimethoate exposure and recovery in the freshwater air-breathing catfish, Heteropneustes fossilis(Bloch)

Cited by 5 publications

References 17 publications

Dimethoate Induced Changes in Serum Ca2+ and Corpuscles of Stannius in Freshwater Catfish Heteropneustes fossilis, after Short-Term and Long-Term Exposure

Dimethoate Induced Changes in Serum Ca2+ and Corpuscles of Stannius in Freshwater Catfish Heteropneustes fossilis, after Short-Term and Long-Term Exposure

Combinations of cypermethrin and dimethoate alter behavior, hematology and histology of African Catfish, Clarias gariepinus

Histological Changes in Calcium Regulating Endocrine Gland (Ultimobranchial) After Dimethoate Exposure in Freshwater Catfish &lt;i&gt;Heteropneustes Fossilis&lt;/i&gt;

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Histological Changes in Calcium Regulating Endocrine Gland (Ultimobranchial) After Dimethoate Exposure in Freshwater Catfish <i>Heteropneustes Fossilis</i>