Alterations in skin microvascular function in patients with rheumatoid arthritis and ankylosing spondylitis

Abstract

Patients with chronic systemic inflammatory arthritis presented altered microvascular function and reduced vasodilator capacity of the forearm skin microcirculation.

Microvascular dysfunction in ankylosing spondylitis is associated with disease activity and is improved by anti-TNF treatment

“…Anti-TNF-α treatment restores microvascular function and diminishes peri-capillary edema assessed by capillaroscopy in patients with high disease activity. While impaired microvascular function has been shown recently by smaller studies using invasive methods 17 or in mixed un-defined arthritis populations 18 , we have used appropriately powered population size of subjects with AS with low traditional CV risk. We also demonstrated that simple, non-invasive techniques, available in most rheumatology clinics may be useful in assessing microvascular status.…”

“…We hypothesized that microvascular morphology and function in patients with AS is linked to disease activity and is modifiable by TNF-α inhibitor (TNFi) treatment, reducing disease activity. Presence of microvascular dysfunction has been recently identified in a smaller and mixed populations of patients with inflammatory joint diseases 17,18 . It, however, remains unclear whether this relationship is caused by prevalence of classical CVD risk factors or is linked to AS specific inflammatory factors.…”

Ангіопатія При Анкілозуючому Спондиліті

“…1, 2. Необходимо отметить, что, по дан-ным литературы [6], тяжесть сосудистых изменений при АС прямо коррелирует с концентрациями в крови CRP и фибриногена.…”

“…АС относится к факторам риска тяжелой сосуди-стой патологии [3,10], а вследствие васкулита мелких сосудов нарушается кровообращение сердца и голов-ного мозга, причем такие кардио-и цереброваскуляр-ные изменения коррелируют с продолжительностью патологического процесса [14], а также с тяжестью изменений опорно-двигательного аппарата [6]. Для АС характерно развитие аортита (иногда с формирова-нием аневризм [13]), что требует проведения диффе-ренциальной диагностики с аортоартериитом Такаясу и другими системными крупнососудистыми васкули-тами [4,9].…”

Fundamental supply of skin blood flow in the Chinese Han population: Measurements by a full‐field laser perfusion imager

“…Skin microcirculation is defined as the capillaries in the skin, which is the critical factor that influences the entire skin surface, regulates temperature and inflammatory response . According to many previous literatures, quantity of cutaneous microvascular perfusion is closely linked to severities of many diseases, from skin abnormities to systemic diseases such as diabetes, ankylosing spondylitis and rheumatoid arthritis . Furthermore, the abnormity in cutaneous microcirculation is the foundation of some pathologies such as psoriasis .…”