Alterations in smell or taste in individuals infected with SARS-CoV-2 during periods of Omicron variant dominance

Song, Jian; Jing, Qi; Zhu, Enzhao; Liu, Qidong; Fei, Miaomiao; Zhang, Hui; An, Guanghui; Cao, Silu; Tang, Jinxuan; Xu, Guanghui; Liu, Yi; Ai, Zisheng; Tao, Yingna; Li, Cheng; Xiong, Lize

doi:10.1016/j.ijid.2023.01.017

Cited by 11 publications

(10 citation statements)

References 30 publications

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“…found that patients who initially presented with myalgia were subsequently more prone to developing alterations in their sense of smell and taste. 17 In our study, 47% of the participants showed a similar proportion of anosmia and ageusia, a finding that aligns with previous research. 12,18 Vihta et al found that the proportion of ageusia/anosmia was 44%/45% during the Omicron variant BA.1 period and was 15%-16%/12%-13% during the Omicron variant BA.2 period, suggesting a significant difference in symptoms among different substrains.…”

Section: Discussionsupporting

confidence: 92%

Symptom profiles and vaccination status for COVID‐19 after the adjustment of the dynamic zero‐COVID policy in China: An observational study

Zhang

Fan

et al. 2023

Journal of Medical Virology

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There has been a substantial rise in coronavirus disease 2019 (COVID-19) cases after adjusting the dynamic zero-COVID policy in China. We conducted a survey to investigate the self-perceived symptom profile and its association with vaccination status during this outbreak. There were 552 individuals in this survey. The infected individuals displayed various symptoms associated with different factors. The three most common symptoms were fatigue (92.21%), phlegm (91.49%), and cough (89.31%). Two typical clusters of COVID-19 symptoms were identified through hierarchical clustering: one was the symptoms with a high probability of cooccurrence that primarily involved the upper respiratory tract, and the other was the symptoms with a high prevalence of severe cases that affected multiple systems.Symptoms exhibited distinct across regions. Hebei Province reported the most severe respiratory symptoms, and Chongqing City reported the worst neurological and digestive symptoms. Cough and fatigue occurred together in most regions.Nevertheless, the cough severity of Zhejiang, Liaoning, and Yunnan provinces was lower than in other areas (t-test p < 0.001). Regression analysis suggested a potential protective effect of recent vaccination on some symptoms. Compared with people who had been vaccinated within half a year, those for more than 1 year had a higher risk of developing phlegm, cough, vertigo, and nausea (all p < 0.05). Our study illustrated the characteristics and symptom profiles of COVID-19 during this wave and provided data supporting its relationship with multiple factors. These findings offered new insights into the recent COVID-19 pandemic in China.

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Section: Discussionsupporting

confidence: 92%

Symptom profiles and vaccination status for COVID‐19 after the adjustment of the dynamic zero‐COVID policy in China: An observational study

Zhang

Fan

et al. 2023

Journal of Medical Virology

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“…The prevalence of anosmia in our study was 23.3%, hyposmia was 42.5%, ageusia was 19.0% and hypogeusia was 40.1%. Studies have also found that the prevalence of smell and taste disorder has decreased in the period of Omicron variant dominance but it still more than 30%, which was similar to our study (Boscolo Rizzo et al 2022;Jian Song et al 2023).…”

Section: Discussionsupporting

confidence: 92%

“…The prevalence of anosmia in our study was 23.3%, that of hyposmia was 42.5%, ageusia was 19.0%, and hypogeusia was 40.1%. Studies have also found that the prevalence of smell and taste disorder decreased during the period of Omicron variant dominance, but remained more than 30%, similar to our findings (28,34) . Males are reported to be more prone to loss of smell and taste senses than females (35) ; however, our data demonstrate that females were more prone to complete loss of olfaction, similar to the findings of Lechien et al (6,8) .…”

Section: Chemesthesis Disordersupporting

confidence: 91%

“…In the current study, we found that the prevalence of smell, taste and chemesthesis disorder in 1245 patients with COVID-19 during the period of Omicron variant dominance was about 69.2%, 67.7% and 31.4% respectively. Previous studies reported the prevalence of olfactory dysfunction ranging from 3.2% to 98.3% and taste dysfunction ranging from 5.6% to 62.7% (Jian Song et al 2023; Agyeman et al 2020). The prevalence of smell, taste and chemesthesis disorder in previous research was various among different population, assessment methods and virus strains (Jian Song et al 2023).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported the prevalence of olfactory dysfunction ranging from 3.2% to 98.3% and taste dysfunction ranging from 5.6% to 62.7% (Jian Song et al 2023; Agyeman et al 2020). The prevalence of smell, taste and chemesthesis disorder in previous research was various among different population, assessment methods and virus strains (Jian Song et al 2023). A meta-analysis based on data from 24 studies including over 8400 participants from 13 countries found the pooled prevalence of patients with smell and taste dysfunction was 41.0% and 38.2% (Agyeman et al 2020).…”

Section: Discussionmentioning

confidence: 99%

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Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 Omicron variant in China

Chen

Liu

et al. 2023

Preprint

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Many studies have confirmed that chemosensory disorder (including smell, taste and chemesthesis) is one of the symptoms of COVID-19 infection. However, new data indicated that the changes of chemosensory sensation caused by COVID-19 may be different among different populations and COVID-19 variants. At present, there are few studies focusing on the influence of Omicron on qualitative changes and quantitative reductions of chemosensory in China. We conducted a cross‑sectional study on COVID-19 Omicron variant patients to investigate the prevalence of chemosensory disorders and their chemosensory function before and during infection by online questionnaire. A total of 1245 patients with COVID-19 completed the study. The prevalence of smell, taste and chemesthesis disorder was 69.2%, 67.7% and 31.4% respectively. Sex, age, smoking and COVID-19-related symptoms such as lack of appetite, dyspnea and fatigue may have association with chemosensory disorders during COVID-19. Self-ratings of chemosensory function revealed that patients experienced a decline in the function of smell, taste and chemesthesis generally. Further studies are needed to combine the data using objective assessment and investigate the factors affecting chemosensory in COVID-19 through longitudinal research.

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Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 during Omicron variant pandemic in China

Chen,

Chen

et al. 2023

Heliyon

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Alterations in smell or taste in individuals infected with SARS-CoV-2 during periods of Omicron variant dominance

Cited by 11 publications

References 30 publications

Symptom profiles and vaccination status for COVID‐19 after the adjustment of the dynamic zero‐COVID policy in China: An observational study

Symptom profiles and vaccination status for COVID‐19 after the adjustment of the dynamic zero‐COVID policy in China: An observational study

Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 Omicron variant in China

Smell, taste and chemesthesis disorders in patients with the SARS-CoV-2 during Omicron variant pandemic in China

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