Alterations in T-helper cell type 1 and blood cell parameters in malaria-infected patients

Babamale, Olarewaju Abdulkareem; Abdulkareem, Adam Olaitan; Opeyemi, Olufunke Adenike; Ugbomoiko, Uade Samuel

doi:10.1016/j.ejbas.2017.05.002

Cited by 3 publications

(2 citation statements)

References 46 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, our observation depicts an increased parasites' competition for hosts' daily metabolic demand, resulting in lowering of oxygen-carrying capacity below the body physiological needs in the infected patients. However, the occurrence of anaemia and thrombocytopenia in malaria infected patients is not uncommon in many malaria-endemic regions in sub-Saharan Africa (Grynberg et al 2007;Erhart et al 2004;Price et al 2001;Kotepui et al 2015;Babamale et al 2017). Our report of 60% thrombocytopenic malaria-infected patients in this study confirms these reports.…”

Section: Discussionsupporting

confidence: 87%

“…Most affected individuals are characterized by poor school performance, low immune function and increased susceptibility to infections (Dia and Ismael 2012). Other disease conditions such as thrombocytopenia, leucopenia and lymphopenia are common concomitant haematological alterations in anemic individuals (Babamale et al 2017). These alterations vary with the density of parasitaemia, hemoglobinopathy, nutritional status, and host immunological status (Erhart et al 2004;Price et al 2001;Kotepui et al 2015).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Malaria-induced anaemia and serum micronutrients in asymptomatic Plasmodium falciparum infected patients

et al. 2017

View full text Add to dashboard Cite

Interaction between malaria, anaemia and malnutrition is poorly understood in asymptomatic malaria patients. This information is important in the management of malaria infection in many endemic regions in sub-Saharan Africa. Malaria parasitaemia, full blood counts and serum levels of essential micronutrients particularly iron (Fe), zinc (Zn) and copper (Cu) of the patients attending Health Centres in Ilorin, Kwara state were investigated using microscope, auto-haemanalyzer and atomic absorption spectrophotometer respectively. A total of 123 (55.2%) of our study population were positive of . Infection was age-specific ( < 0.0001), and a significant proportion (88.6%) of malaria infected patients were 28.5% mild, 45.5% moderate and 14.6% severely anaemic. The severity of anaemia increases as parasite density increases. Analysis of serum micronutrients revealed a significant low level of iron (3.72 mg/l), copper (2.05 mg/l) and zinc (3.67 mg/l) in infected patients (p < 0.0001); which further increased their anaemic condition. This study confirmed a significant relationship between severity of anaemia and nutritional deficiency in the pathogenesis of malaria infection. We therefore, recommend that immunomodulation potential of micronutrients may be essential in the management of malaria infection.

show abstract

Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Malaria-induced anaemia and serum micronutrients in asymptomatic Plasmodium falciparum infected patients

et al. 2017

View full text Add to dashboard Cite

show abstract

High parasitaemia correlates with malaria episodes and the socioeconomic impact of recurrent malaria infection in high-transmission zone of Nigeria

et al. 2022

View full text Add to dashboard Cite

Background Recurrent malaria infection is a major phenomenon in a hightransmission zone with deplorable health and socioeconomic consequences on individuals and the public. However, the association between parasitaemia, repeated episodes of the infection, and its socioeconomic impact is less studied. Therefore, this study aimed at bridging this research gap by conducting an epidemiological survey in selected malaria-endemic settings of Kwara state, Nigeria. Results High prevalence and intensity of infection were observed, 56.6% of 572 study participants were infected with average parasitaemia of 3022.25 ± 1001.51 per µl of blood and the majority of heavy infection was due to Plasmodium falciparum. The heavily asymptomatic infected participants were among the younger age group particularly ≤ 20 years, and infection decreases with increasing age. Parasitaemia and the number of episodes of malaria attacks were positively correlated (R2 = 0.2388, p < 0.0001). Highrecurrent malaria was associated with male (p = 0.001), younger age (p = 0.0012), low-income status (p = 0.0004), bush around habitation (0.0014), and unavoidability of preventive strategies and treatment (p < 0.0001) of malaria. Our study further revealed socioeconomic factors as cause and/or consequence of recurrent malaria infection. Low income individuals (aOR 1.948 95%CI 0.945–2.512) and illiterates (aOR 1.920 95%CI 1.470–2.149), those living close to bush (aOR 2.501 95%CI 2.033–3.714) and dumpsite (aOR 2.718 95%CI 1.661–3.118) are at least twice likely to have recurrent infection. The socioeconomic consequence of recurrent malaria episodes includes reduced economic activities, personal savings, and change of lifestyle in adults, while infected children suffered declined academic performance and sports activities. Conclusions This study underscores high malaria intensity as a prevalent health problem in our study location and demonstrates a positive correlation between malaria episodes and parasitaemia which can be explored in the clinic for the screening of suitable antimalarial drugs that cure beyond a single infection. Our finding also advocates for mass distribution of insecticide-treated nets, provision of socio-infrastructural amenities such as medical centers, good drainage system and highly subsidized malaria treatment in endemic endemic rural communities

show abstract

Extract of Morinda lucida leaf rescues hypoglycaemic and dyslipidaemic conditions in Plasmodium berghei-infected mice

Abdulkareem

Babamale

Anifowoshe

et al. 2022

Bull Nat Sci Research

View full text Add to dashboard Cite

Increasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into alternative therapy to mitigate malaria-associated damages is important. In this study, we investigated the anti-hypoglycaemic and anti-hyperlipidaemic effects of aqueous extract of Morinda lucida leaf in Plasmodium berghei-infected mice. Twenty-five mice were randomly grouped into five: Uninfected, infected-untreated, chloroquine (20 mg/kg, per oral), and extract-treated (400 mg/kg and 800 mg/kg, respectively, per oral) groups. Fasting blood glucose was measured before parasite inoculation and after the last treatment. Blood was collected for lipid profile assay at the end of the 4-day treatment. Our results revealed that both chloroquine and the extract lowered parasite growth (p <0.05), while chloroquine and 400 mg/kg of the extract improved blood glucose in Plasmodium berghei-infection. More so, all the treated groups showed attenuated Plasmodium berghei-induced dyslipidaemia, with 400 mg/kg of the extract exhibiting better efficacy. Therefore, this study suggests that Morinda lucida leaf extract can be harnessed as a therapeutic regimen for improved malaria treatments and associated complications. Further study is recommended to elucidate the mechanism of anti-hypoglycaemic and anti-hyperlipidaemic activities of the extract and the possible bioactive compound(s) involved.

show abstract

Alterations in T-helper cell type 1 and blood cell parameters in malaria-infected patients

Cited by 3 publications

References 46 publications

Malaria-induced anaemia and serum micronutrients in asymptomatic Plasmodium falciparum infected patients

Malaria-induced anaemia and serum micronutrients in asymptomatic Plasmodium falciparum infected patients

High parasitaemia correlates with malaria episodes and the socioeconomic impact of recurrent malaria infection in high-transmission zone of Nigeria

Extract of Morinda lucida leaf rescues hypoglycaemic and dyslipidaemic conditions in Plasmodium berghei-infected mice

Contact Info

Product

Resources

About