Alterations in the brain electrical activity in a rat model of sepsis-associated encephalopathy

Kafa, İ̇lker Mustafa; Bakirci, Sinan; Uysal, Murat; Kurt, Mustafa Ayberk

doi:10.1016/j.brainres.2010.07.049

Cited by 31 publications

(15 citation statements)

References 47 publications

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“…Neurophysiologists have developed various experimental techniques to study neuronal cell activity. Neuronal activities recordings can be classified as follows: (1) [89], and Wang et al also showed suppression of local field potentials during sensory stimulation in SE [30]. These findings are clearly similar to the clinical state of sensory dysfunction in septic patients [90].…”

Section: Electrophysiologysupporting

confidence: 72%

In Vivo Imaging of Septic Encephalopathy

Imamura¹,

Murakami²,

Matsumoto³

et al. 2017

Sepsis

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Septic encephalopathy is a devastating symptom of severe sepsis. Many studies have been performed to uncover the pathophysiological mechanisms of septic encephalopathy; however, novel technical approaches are still required to overcome this complex symptom. Because patients are suffering from severe cognitive impairment, coma, or delirium, which burden not only patients but also caregivers, overcoming septic encephalopathy is still a major social problem worldwide, especially in the intensive care. Septic encephalopathy seems to be caused by cytokine invasion and/or oxidative stress into the brain, and this pathological state leads to imbalance of neurotransmitters. In addition to this pathophysiology, septic encephalopathy causes complicated symptoms (e.g., ischemic stroke, edema, and aberrant sensory function). For these pathophysiological mechanisms, electrophysiology using animal models, positron emission tomography (PET), computed tomography, and magnetic resonance imaging for septic patients has provided important clues. However, the research for septic encephalopathy is currently confronted with the difficulty of complex symptoms. To overcome this situation, in this chapter, we introduce our novel methods for in vivo imaging of septic encephalopathy using near infrared (NIR) nanoparticles, quantum dots. In addition to our recent progress, we propose a strategy for the future approach to in vivo imaging of septic encephalopathy.

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Section: Electrophysiologysupporting

confidence: 72%

In Vivo Imaging of Septic Encephalopathy

Imamura¹,

Murakami²,

Matsumoto³

et al. 2017

Sepsis

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“…Sepsis‐associated encephalopathy is the most common form of encephalopathy in people with an incidence of 8–70% of people with sepsis in the ICU . However, the recognition of SAE often is hindered by the use of sedatives for mechanical ventilation.…”

Section: Individual Organ System Dysfunctionmentioning

confidence: 99%

Multiple Organ Dysfunction Syndrome in Humans and Animals

Osterbur¹,

Mann

Kuroki

et al. 2014

Veterinary Internal Medicne

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Multiple organ dysfunction syndrome (MODS), defined as the presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention, is a cause of high morbidity and mortality in humans and animals. Many advances have been made in understanding the pathophysiology and treatment of this syndrome in human medicine, but much still is unknown. This comparative review will provide information regarding the history and pathophysiology of MODS in humans and discuss how MODS affects each major organ system in animals.

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“…Clinical symptoms observed during SE affect 8–70 % of patients with diagnosed sepsis [54] and include inattention, confusion, and considerable excitation, which may lead to stupor and coma. The first symptoms usually appear in the early stage of sepsis, often before other organ disturbances are diagnosed [55, 56], and represent the severest symptoms, such as weakness, anorexia, malaise, and concentration deficits.…”

Section: Clinical Symptoms Of Septic Encephalopathymentioning

confidence: 99%

Septic Encephalopathy

Ziaja

2013

Curr Neurol Neurosci Rep

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Every year, more cases of sepsis appear in intensive care units. The most frequent complication of sepsis is septic encephalopathy (SE), which is also the essential determinant of mortality. Despite many years of research, it still is not known at which stage of sepsis the first signs of SE appear; however, it is considered the most frequent form of encephalopathy. Patients have dysfunction of cognitive abilities and consciousness, and sometimes even epileptic seizures. Despite intensive treatment, the effects of SE remain for many years and constitute an important social problem. Numerous studies indicate that changes in the brain involve free radicals, nitric oxide, increased synthesis of inflammatory factors, disturbances in cerebral circulation, microthromboses, and ischemia, which cause considerable neuronal destruction in different areas of the brain. To determine at what point during sepsis the first signs of SE appear, different experimental models are needed to detect the aforementioned changes and to select the proper therapy for this syndrome.

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Alterations in the brain electrical activity in a rat model of sepsis-associated encephalopathy

Cited by 31 publications

References 47 publications

In Vivo Imaging of Septic Encephalopathy

In Vivo Imaging of Septic Encephalopathy

Multiple Organ Dysfunction Syndrome in Humans and Animals

Septic Encephalopathy

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