Alterations in the Gut Microbiota and Metabolomics of Seafarers after a Six-Month Sea Voyage

Jiang, Chun-Hui; Xue, Fang; Huang, Wen; Guo, Jian-You; Chen, Jia-Yun; H, Wu; Li, Zhao‐Shen; Zou, Wen Bin; Liao, Zhuan

doi:10.1128/spectrum.01899-22

Cited by 3 publications

(2 citation statements)

References 44 publications

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“…Previous research has also indicated an association between gut microbiota imbalance and certain mental disorders such as anxiety and depression. Jiang’s high-throughput sequencing analysis of 46 depressed patients and 30 healthy controls showed significantly higher abundance of Actinobacteria and Firmicutes in the healthy control group at the phylum level compared to the depressed patients ( 27 ). Moreover, previous MR studies have indicated a protective effect of Actinobacteria against major depressive disorder (MDD) incidence (OR 0.88, 95% CI 0.87-0.9) ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is worth mentioning that depressed patients often have lower levels of omega-3 fatty acids ( 33 ). While there is no consensus on whether supplementing omega-3 alone can effectively alleviate depression, it has been observed that consuming omega-3-rich fish may be associated with increased abundance of Holdemanella genus ( 27 ). Could increasing the abundance of Holdemanella genus and reducing the risk of postpartum depression be achieved through omega-3 supplementation?…”

Section: Discussionmentioning

confidence: 99%

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Gut microbiota and postpartum depression: a Mendelian randomization study

Zhang,

Wei,

Tan

et al. 2024

Front. Psychiatry

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BackgroundIncreasing evidence suggests a correlation between intestinal microbiota and the gut-brain axis; however, the causal relationship between gut microbiota and postpartum depression (PPD) remains unclear.MethodsIn this study, a two-sample Mendelian randomization (MR) design was employed to analyze the GWAS data of gut microorganisms from the Mibiogen database and PPD data from the UK biobank. Various statistical methods, including inverse variance weighted, MR-Egger, weighted median, weighted model, and MR-PRESSO, were utilized to investigate the causal relationship between gut microbiota and PPD. Additionally, sensitivity analysis was conducted to assess the robustness of the findings.ResultsThrough MR analysis, it was found that phylum Actinobacteria (P=0.014, OR=0.971, 95% CI=0.948-0.994) and genus Holdemanella (P=0.023, OR=0.979, 95% CI=0.961-0.997) have protective effects on PPD, while the other two unknown genera, genus Unknown Ids 2001 (P=0.025, OR=0.972,95% CI=0.947-0.996), and genus Unknown Ids 2755 (P=0.012, OR=0.977, 95% CI=0.959-0.995) also has a protective effect on PPD. The sensitivity analysis results indicate that there is no heterogeneity or horizontal pleiotropy.ConclusionThis study has identified a causal association between Actinomycetota, Holdemanella, and PDD through MR analysis. These findings offer significant contributions to the development of personalized treatment approaches for PPD, encompassing interventions such as dietary modifications or microbiome interventions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gut microbiota and postpartum depression: a Mendelian randomization study

Zhang,

Wei,

Tan

et al. 2024

Front. Psychiatry

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Dietary inositol supplementation improves meat quality by modulating amino acid metabolism and gut microbiota composition of finishing pigs

Yan,

Sun,

et al. 2024

Animal Nutrition

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Analysis of the gut microbiota and fecal metabolites in people living with HIV

Tian,

Xie,

et al. 2024

Microbiol Spectr

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The gut microbiome has a pivotal function in human immunodeficiency virus (HIV). However, the associated alterations in the gut microbiome-host interaction are unknown. Herein, we aimed to investigate the gut microbiota and fecal metabolites in people living with HIV (PLWH). We collected stool samples from 70 PLWH and 34 healthy controls (HCs) and carried out 16S rRNA gene sequencing and analyzed the metabolites using liquid chromatography-mass spectrometry. Firmicutes , Proteobacteria , Actinobacteriota , and Bacteroidota were the most abundant phyla in both groups. Among genera, the level of Escherichia - Shigella was upregulated significantly in the PLWH group, whereas in the HC group, Bacteroides spp. were upregulated. Prediction of microbial function indicated significant reductions in alanine, aspartate, glutamate, and histidine metabolism. Furthermore, a comparison of the fecal metabolites between the HC and PLWH groups identified 38 differentially abundant metabolites in four differentially enriched human metabolic pathways. According to Spearman correlation analysis, there are close relationships between four differentially abundant microbiota members and five differentially abundant fecal metabolites, which might influence particular human metabolic pathways. Our findings provide a basis for further experimental investigation of the contribution of the gut microbiota and its associated metabolites to HIV/AIDS, providing a novel perspective for the further study of HIV/AIDS. IMPORTANCE Growing evidence demonstrates that the gut microbiota is associated with HIV. This study investigated changes in the gut microbiota and fecal metabolites in PLWH. We identified 38 differentially abundant metabolites in four differentially enriched human metabolic pathways. Moreover, close relationships were noted between the four differentially abundant microbiota members and five differentially abundant fecal metabolites, which might influence particular human metabolic pathways. Thus, to benefit PLWH, potential pathobionts could be reduced (e.g., g_ Enterococcus ); probiotics could be increased (e.g., g_ Faecalibacterium and g_ Agathobacter ); or certain metabolites (e.g., N-acetyl-L-phenylalanine and trehalose) could be reduced by changes in diet or the use of nutritional supplements. Our results provide insights into the interaction between the gut microbiota and the host, identifying possible targets that might be beneficial for PLWH.

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Alterations in the Gut Microbiota and Metabolomics of Seafarers after a Six-Month Sea Voyage

Cited by 3 publications

References 44 publications

Gut microbiota and postpartum depression: a Mendelian randomization study

Gut microbiota and postpartum depression: a Mendelian randomization study

Dietary inositol supplementation improves meat quality by modulating amino acid metabolism and gut microbiota composition of finishing pigs

Analysis of the gut microbiota and fecal metabolites in people living with HIV

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