Alterations in the level of insulin receptor and GLUT-4 mRNA in skeletal muscle from rats fed a kidney bean (Phaseolus vulgaris) diet

Knott, Rachel M.; Grant, George; Bardócz, Susan; Pusztai, Á.; Carvalho, A. C. P. P. de; Hesketh, John E.

doi:10.1016/0020-711x(92)90094-h

Cited by 22 publications

(9 citation statements)

References 17 publications

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“…It is interesting to note a similar observation made about the effect of a well studied food product containing an α-amylase inhibitor, namely kidney bean (Phaseolus vulgaris), on rats. In that study, insulin plasma levels decreased when rats were fed kidney beans, while the amount of mRNAs for the insulin receptor and GLUT-4 increased in a specific muscle type (Knott et al, 1992). The effect observed in the current study must be associated with the presence of chalcone and is independent of the pathological condition of diabetic rats, since it is also observed in non-diabetic rats, although the effect is less pronounced.…”

Section: Insulinsupporting

confidence: 49%

Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats.

Najafian

Ebrahim‐Habibi²,

Yaghmaei³

et al. 2010

Acta Biochim Pol

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trans-chalcone is the core structure of naringenin chalcone, located halfway in the biosynthesis pathway of flavonoids. Flavonoids have been reported as mammalian alpha-amylase inhibitors, a property which could be useful in the management of postprandial hyperglycemia in diabetes and related disorders. As a mammalian alphaamylase inhibitor in vitro, the putative beneficial effect of trans-chalcone on diabetes was tested in a streptozotocin-induced rat model of diabetes type 1, and the results analyzed with commonly used statistical methods. Significant reduction of blood glucose levels and beneficial effect on dyslipidemia were observed in diabetic rats, as well as reduction of disturbing consequences of diabetes such as high urine volume and water intake. trans-chalcone was observed to have a weight loss-inductive effect, alongside with a reduction in food intake, which is suggestive of a therapeutic potential of this compound in overweight and obese patients.

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Section: Insulinsupporting

confidence: 49%

Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats.

Najafian

Ebrahim‐Habibi²,

Yaghmaei³

et al. 2010

Acta Biochim Pol

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“…In other animals, soybean or other plant lectins have also been reported to cause hyperplastic growth of intes ajiri et Pusztai et al, 1990;Bardocz et al, 1992 andBanwell et a 1993); decreased cell turnover time (Pusztai et al, 1990); uptake of lectin via endocytosis intestinal epithelial cells (Pusztai et al, 1981;Banwell et al, 1984;King et al, 1986;Bardoc et al, 1995); changes in pancreatic weight and enzyme secretion (Greer and Pusztai, 1985;Huisman et al, 1990;Banwell et al, 1993;Pusztai et al, 1993a;Grant et al, 1997); changes in liver weight (Oliveira et al, 1988;Aletor, 1989); reduced plasma insulin levels (Knott et al, 1992;Bardocz et al, 1996;Pusztai et al, 1998); increased cholecystokinin (CCK) release (Jordinson et al, 1996 and; and reduced skeletal muscle mass (Oliveira et al, 1988;Bardocz et al, 1992).…”

Section: Biological Effects In Fish General Considerationsmentioning

confidence: 99%

Criteria for Safe Use of Plant Ingredients in Diets for Aquacultured Fish

Hemre

Amlund

Aursand

et al. 2018

EJNFS

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“…InR mRNA levels also change in animals depending on fasting-feeding conditions. For example, rats fed a high-fat diet display a decreased number of InR molecules in liver plasma membranes (Sun et al 1977), and InR mRNA levels in rat skeletal muscle or liver increase after fasting, returning to normal levels after insulin treatment or refeeding (Knott et al 1992;Tozzo and Desbuquois 1992). Interestingly, tissues other than muscle or liver might have similar regulation.…”

Section: Foxo1 Regulates Inr Transcriptionmentioning

confidence: 99%

Transcriptional feedback control of insulin receptor by dFOXO/FOXO1

Puig¹,

Tjian²

2005

Genes Dev.

328

265

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The insulin signaling pathway, which is conserved in evolution from flies to humans, evolved to allow a fast response to changes in nutrient availability while keeping glucose concentration constant in serum. Here we show that, both in Drosophila and mammals, insulin receptor (InR) represses its own synthesis by a feedback mechanism directed by the transcription factor dFOXO/FOXO1. In Drosophila, dFOXO is responsible for activating transcription of dInR, and nutritional conditions can modulate this effect. Starvation up-regulates mRNA of dInR in wild-type but not dFOXO-deficient flies. Importantly, FOXO1 acts in mammalian cells like its Drosophila counterpart, up-regulating the InR mRNA level upon fasting. Mammalian cells up-regulate the InR mRNA in the absence of serum, conditions that induce the dephosphorylation and activation of FOXO1. Interestingly, insulin is able to reverse this effect. Therefore, dFOXO/FOXO1 acts as an insulin sensor to activate insulin signaling, allowing a fast response to the hormone after each meal. Our results reveal a key feedback control mechanism for dFOXO/FOXO1 in regulating metabolism and insulin signaling.

show abstract

Alterations in the level of insulin receptor and GLUT-4 mRNA in skeletal muscle from rats fed a kidney bean (Phaseolus vulgaris) diet

Cited by 22 publications

References 17 publications

Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats.

Core structure of flavonoids precursor as an antihyperglycemic and antihyperlipidemic agent: an in vivo study in rats.

Criteria for Safe Use of Plant Ingredients in Diets for Aquacultured Fish

Transcriptional feedback control of insulin receptor by dFOXO/FOXO1

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