Alterations in the ocular surface and tear film following keratoplasty

Meyer, Jay J.; Gokul, Akilesh; Wang, Michael T.M.; Sung, Justin; Craig, Jennifer P.

doi:10.1038/s41598-022-16191-6

Cited by 6 publications

(3 citation statements)

References 45 publications

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“…Decreased corneal sensation may result in reduced tear production, which in turn can lead to irritation and dry eyesymptoms. 7,8 Almost 40,000 cataract surgeries are performed each year in Layton Rahmatulla Benevolent Trust Eye and Cancer Hospital, Lahore. Due to this large number of cataract surgeries with associated increase in DED, it becomes important to study the frequency of dry eye symptoms in post-surgical patients.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Dry Eyes after Cataract Surgery and Effect of Gender, Duration of Cataract and Age on Dry Eye Symptoms after Phacoemulsification

et al. 2022

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Purpose: To determine the frequency of dry eyes in patients after cataract surgery and to find out the effect of gender, duration of cataract and age on dry eye symptoms after phacoemulsification. Study Design: Descriptive Observational study. Place and Duration of Study: Layton Rehmatulla Benevolent Trust Free Eye and Cancer Hospital, Lahore from October 2015 to April 2016. Methods: One hundred and twenty patients between 40-80 years of age and suffering from cataract were included. Past medical history and current medical information was recorded. To control bias, only one experienced surgeon carried out the procedures. Follow-up was done at 1st post-operative day, one week, one month and 3 months. Tear film break up time was noted at each visit. Quantitative variables like age and tear film break-up time (TBUT) were presented as mean ± SD. The Qualitative variables were presented as frequency and percentages. Data was stratified according to age, gender and duration of cataract. Post-stratification Chi-square test was applied and p-value ≤0.05 was considered significant. Results: Out of 120 patients, there were 47 (39%) males and 73 (61%) females. A total of 35 (29.2%) patients had dry eyes. Mean age was 59.11 ± 12.358 years while mean TBUT was 11.27 ± 2.582 seconds. There was no relation of dry eye with gender, duration of cataract and different age groups (p > 0.05). Conclusion: Frequency of Dry eyes after cataract surgery was 29.2% (n = 35). There was no effect of gender, duration of cataract and age of the patient on the post-operative TBUT after phacoemulsification.

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Section: Introductionmentioning

confidence: 99%

Frequency of Dry Eyes after Cataract Surgery and Effect of Gender, Duration of Cataract and Age on Dry Eye Symptoms after Phacoemulsification

et al. 2022

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“…In addition, patients preparing for cataract surgery or vitrectomy may not always have normal corneas and may have had previous ocular trauma or keratoplasty, etc. Meyer JJ et al showed that keratoplasty can induce persistent changes in the ocular surface and tear film, leading to the signs and symptoms of dry eye disease [ 8 ]. Therefore, how to protect the corneal epithelium during surgery is a key concern for surgeons.…”

Section: Discussionmentioning

confidence: 99%

A Multicenter Prospective Randomized Controlled Study of a New Corneal Wetting Agent During Ophthalmologic Surgery

Chen,

Zhang,

Tian

et al. 2023

Ophthalmol Ther

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Introduction A multicenter prospective randomized controlled study was used to investigate the effect and safety of a new corneal wetting agent called the Corneal Surface Viscoelastic Protector (CsVisc, Success Bio-Tech Co., Ltd, China), on the corneal epithelium during ophthalmic surgery by comparison with the commercially available Cornea Protect (CP, Valeant Med Sp. zo. o. Leobendorf, Austria). Methods This multicenter prospective randomized controlled study comprised patients scheduled for cataract surgery and pars plana vitrectomy. The patients were randomly assigned to receive either a new corneal wetting agent (CsVisc) or Cornea Protect (CP, Valeant Med Sp. zo. o. Leobendorf, Austria). Optical clarity during surgery, application frequency, duration of effect, diffusion time of corneal wetting agents, fluorescein staining, intraocular pressure (IOP), tear-film break-up time (TBUT), and Schirmer I test (SIT) were assessed. Adverse events were noted on the designated patient case report forms. Results A total of 149 eyes (149 patients, mean age 62 years; range 25–80 years) were included in the study. There were 74 eyes in the control group and 75 eyes in the study group. In patients who underwent vitrectomy, the frequency of application was 1.62 ± 1.03 in the study group and 1.39 ± 0.66 in the control group, with no significant difference ( P = 0.399), and the duration of effect was 19.16 ± 6.94 min in the study group and 19.06 ± 7.22 min in the control group, with no significant difference ( P = 0.835). The optical clarity of the study group was not significantly different from that of the control group ( P = 0.485). In patients who underwent cataract surgery, the frequency of application was 1.10 ± 0.38 in the study group and 1.07 ± 0.26 in the control group, and the difference was not significant ( P = 0.950). The difference between the duration of effect in the study group (8.32 ± 2.50 min) and the control group (7.63 ± 2.52 min) was not significant ( P = 0.310). The difference in optical clarity scores between the two groups was not statistically significant ( P = 0.600). Among all patients in this study, the diffusion time of the corneal wetting agent was 14.97 ± 10.07 s in the control group and 11.23 ± 8.41 s in the study group, with a statistically significant difference ( p = 0.008). The frequency of adverse events was 20.00% (15/75) in the study group and 14.86% (11/74) in the control group, with no statistically significant difference ( P = 0.409). There were no serious adverse events related to the test medical device or causing patients to withdraw from the study. Conclusions The CsVisc is safe and effective in preventing intraoperative corneal epithelial damage due to corneal dryn...

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“…A transplant performed due to infectious keratitis also increases the risk of PKMK [28]. Finally, reduced corneal sensitivity contributes to a high risk of PKMK [29].…”

Section: Risk Factorsmentioning

confidence: 99%

Post-Keratoplasty Microbial Keratitis in the Era of Lamellar Transplants—A Comprehensive Review

Przybek-Skrzypecka,

Samelska,

Ordon

et al. 2024

JCM

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Microbial keratitis in a post-transplant cornea should be considered a distinct entity from microbial keratitis in a non-transplant cornea. Firstly, the use of immunosuppressive treatments and sutures in corneal transplants changes the etiology of keratitis. Secondly, corneal transplant has an impact on corneal biomechanics and structure, which facilitates the spread of infection. Finally, the emergence of lamellar transplants has introduced a new form of keratitis known as interface keratitis. Given these factors, there is a clear need to update our understanding of and management strategies for microbial keratitis following corneal transplantation, especially in the era of lamellar transplants. To address this, a comprehensive review is provided, covering the incidence, risk factors, causes, and timing of microbial keratitis, as well as both clinical and surgical management approaches for its treatment in cases of penetrating and lamellar corneal transplants.

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Alterations in the ocular surface and tear film following keratoplasty

Cited by 6 publications

References 45 publications

Frequency of Dry Eyes after Cataract Surgery and Effect of Gender, Duration of Cataract and Age on Dry Eye Symptoms after Phacoemulsification

Frequency of Dry Eyes after Cataract Surgery and Effect of Gender, Duration of Cataract and Age on Dry Eye Symptoms after Phacoemulsification

A Multicenter Prospective Randomized Controlled Study of a New Corneal Wetting Agent During Ophthalmologic Surgery

Post-Keratoplasty Microbial Keratitis in the Era of Lamellar Transplants—A Comprehensive Review

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