Alterations in the peripheral circulation in COPD patients

Boussuges, Alain; Rossi, P.; Gouitaa, M.; Nussbaum, Eric S.

doi:10.1111/j.1475-097x.2007.00749.x

Cited by 12 publications

(7 citation statements)

References 41 publications

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“…18e22 Noninvasive techniques measuring arterial stiffness and vascular resistance of large and small vessels are increasingly used as surrogate markers for early atherosclerosis and the risk of cardiovascular events. 19,23,24 Previous studies 25,26 have shown that mean aortic pulse wave velocity as well as inflammatory markers and augmentation index, were significantly greater in COPD patients compared to healthy control subjects. The authors concluded that the increased arterial stiffness is related to the severity of the airflow obstruction in COPD.…”

Section: Introductionmentioning

confidence: 98%

Pulmonary function correlates with arterial stiffness in asthmatic patients

Weiler

Zeldin

Magen

et al. 2010

Respiratory Medicine

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Section: Introductionmentioning

confidence: 98%

Pulmonary function correlates with arterial stiffness in asthmatic patients

Weiler

Zeldin

Magen

et al. 2010

Respiratory Medicine

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“…А.Boussuges et al также обнаружили увеличение артерильной ригидности у пациентов с ХОБЛ [12]. Авторы не исключали, что причиной повышения ар териальной ригидности могли быть воздействие си гаретного дыма, гипоксия, системное воспаление, гиперактивность симпатической нервной системы.…”

Section: Discussionunclassified

“…Возможно, именно развитие артериальной ри гидности и эндотелиальной дисфункции является связующим звеном между ХОБЛ и сердечно сосу дистыми заболеваниями (ССЗ). Относительно не давно выполнены исследования, посвященные изу чению механических свойств артерий у больных с респираторной патологией [11][12][13]. Однако кли нико патогенетические и функциональные аспекты этих нарушений неоднозначны и изучены недоста точно.…”

Section: резюмеunclassified

Arterial stiffness and endothelial dysfunction in patients with chronic obstructive pulmonary disease: what is primary and secondary?

Макарова¹,

Авдеев²,

Ag³

2011

Pulʹmonologiâ (Mosk.)

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SummaryThe aim of this study was to investigate relationship between arterial stiffness and endothelial dysfunction, on one hand, and clinical ad functional parameters of chronic obstructive pulmonary disease (COPD), on the other hand. This was a prospective cross sectional comparative study. Arterial stiffness was measured using photoplethysmography (Pulse Trace PCA 2, Micro Medical). We calculated stiffness index (SI) which reflected pulse wave velocity in large arteries, and reflectance index (RI) which is generally related to small vessel tone. Endothelial dysfunction was assessed with RI changes (Δ RISLB) before and after inhalation of salbutamol and also according to serum endothelin 1. The study involved 41 patients with COPD (mean age, 64.5 ± 7.6 yrs; FEV1, 37.7 ± 14.1 %; РаО2, 63.2 ± 11.2 mm Hg). SI was 11.3 ± 3.3 m / s; RI was 69.1 ± 16.6 % in comparison to 6.9 ± 0.9 m / s and 53.6 ± 14.7 %, respectively, in controls (р < 0.05). In COPD patients, Δ RISLB was signif icantly lower compared to controls (1.15 [0 10] % vs 11.50 [6-19] %; р < 0.05). As severity of COPD increased, Δ RISLB decreased (р < 0.05). Serum endothelin 1 in COPD patients was higher than normal level (0.47 [0.23-0.71] vs 0.26 fmol / ml; р < 0.05). Serum endothelin 1 was inverse ly related to RI (R = 0.44; р = 0.02) and Δ RISLB (R = -0.46; р = 0.03). A significant correlation was also found between the indexes and clinical and functional parameters (BMI, RV, DLCO, FEV1, heart beat rate, breathing rate, dyspnea assessment using MRC scale), 6 min walking distance. Therefore, arterial stiffness was significantly higher in COPD patients compared to patients with asthma and healthy volunteers. Increase in arteri al stiffness is linearly related to severity of the disease. Endothelial dysfunction in COPD patients was significantly higher compared to that in com parative groups and was related to arterial stiffness.

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“…Cardiovascular disease is one of the most prevalent comorbidities in COPD [11][12][13][14] . COPD is associated with a 2-3-fold increase in the risk of ischemic heart disease, stroke, and sudden death [ 14 ] .…”

Section: Common Medical Comorbidities Of Copdmentioning

confidence: 99%

Evaluating Cognition in Patients with Chronic Obstructive Pulmonary Disease

Kozora

Hoth

2012

Handbook on the Neuropsychology of Aging and Dementia

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28Chronic obstructive pulmonary disease (COPD) is a chronic progressive pulmonary disease with signi fi cant physical, cognitive, and psychological sequelae. There are several types of restrictive lung diseases (e.g., COPD, emphysema), and although conditions vary across individuals, they are all related to air fl ow limitation. COPD is a preventable/treatable disease; however, the "pulmonary" component, characterized by air fl ow limitation, is not fully reversible. AbstractIn this chapter, we focus on the neuropsychological evaluation of patients with chronic obstructive pulmonary disease (COPD), a common adult pulmonary disorder characterized by restrictive air fl ow and respiratory distress. First, we will review the epidemiology and diagnostic criteria of COPD and of the most common medical comorbidities. Next, we will review the literature of cognition in patients with COPD and identify the most consistent neuropsychological de fi cits in the population. Multidisciplinary rehabilitation is commonly prescribed for COPD patients. We will discuss the role of the neuropsychologist within the team. Finally, to more clearly illustrate the neuropsychological evaluation in patients with COPD, we will discuss a fi ctional case from our center with details regarding frequent referral questions, special considerations for the clinical interview, selection of cognitive tests, interpretation of tests, and fi nal recommendations for the patient and/or the interdisciplinary rehabilitation team. Keywords Pulmonary disease • COPD • Air fl ow limitation • Hypoxia

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Alterations in the peripheral circulation in COPD patients

Abstract: In COPD patients, significant alterations in the peripheral circulation were observed. Moreover, the magnitude of changes in the peripheral circulation was related to the severity of COPD.

Cited by 12 publications

References 41 publications

Pulmonary function correlates with arterial stiffness in asthmatic patients

Pulmonary function correlates with arterial stiffness in asthmatic patients

Arterial stiffness and endothelial dysfunction in patients with chronic obstructive pulmonary disease: what is primary and secondary?

Evaluating Cognition in Patients with Chronic Obstructive Pulmonary Disease

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