Alterations of Basal Lamina of the Seminiferous Epithelium during the Seasonal Suppression of Spermatogenesis in the Japanese Monkey (Macaca fuscata).

Previous studies have demonstrated that the blood-testis barrier (BTB) at the tubuli recti (TR) and the rete testis (RT) is less complete than at the seminiferous tubules (ST). However, there has been no report focusing on the basal lamina, which is an important component of the BTB at both TR and RT. In the present study, we performed electron microscopic observation of the basal lamina at the TR and RT, in comparison with that of those of the ST in normal mice. The results showed that the basal lamina of modified Sertoli cells at the TR segment exhibited a wavy and multilayered structure, but the Sertoli cells of ST and the epithelium of RT had an almost flat and single-layered basal lamina. It was also noted that wide gaps existed between the modified Sertoli cells, the basal lamina of the epithelial layer, and the myoid cell layer at the middle TR segment. This characteristic structure of the basal lamina of the TR epithelial layer may be one of the factors for its incomplete BTB.

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Multilayered structure of the basal lamina of the tubuli recti in normal mice

Tainosho

Naito

Hirai

et al. 2011

Med Mol Morphol

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Spermatogonial kinetics in humans

et al. 2017

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The human spermatogonial compartment is essential for daily production of millions of sperm. Despite this crucial role, the molecular signature, kinetic behavior and regulation of human spermatogonia are poorly understood. Using human testis biopsies with normal spermatogenesis and by studying marker protein expression, we have identified for the first time different subpopulations of spermatogonia. MAGE-A4 marks all spermatogonia, KIT marks all B spermatogonia and UCLH1 all Apale-dark (Ap-d) spermatogonia. We suggest that at the start of the spermatogenic lineage there are Ap-d spermatogonia that are GFRA1, likely including the spermatogonial stem cells. Next, UTF1 becomes expressed, cells become quiescent and GFRA1 expression decreases. Finally, GFRA1 expression is lost and subsequently cells differentiate into B spermatogonia, losing UTF1 and acquiring KIT expression. Strikingly, most human Ap-d spermatogonia are out of the cell cycle and even differentiating type B spermatogonial proliferation is restricted. A novel scheme for human spermatogonial development is proposed that will facilitate further research in this field, the understanding of cases of infertility and the development of methods to increase sperm output.

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Alterations of Basal Lamina of the Seminiferous Epithelium during the Seasonal Suppression of Spermatogenesis in the Japanese Monkey (Macaca fuscata).

Cited by 2 publications

References 25 publications

Multilayered structure of the basal lamina of the tubuli recti in normal mice

Multilayered structure of the basal lamina of the tubuli recti in normal mice

Spermatogonial kinetics in humans

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