Alterations of Dendritic Cell Subsets and Th1/Th2 Cytokines in the Peripheral Circulation of Patients With Superficial Transitional Cell Carcinoma of the Bladder

Abstract

The impairment of mDC counts and MoDC function with imbalance of Th1/Th2 cytokines was closely associated with proliferation and recurrence of STCCB.

Interleukin-10 Superfamily and Cancer

“…Elevated concentrations of IL-10 were detected in subjects with colorectal carcinoma (Szkaradkiewicz et al, 2009;Stanilov et al, 2010;Toiyama et al, 2010;Svobodova et al, 2011;Kemik et al, 2012), esophageal cancer (Kemik et al, 2012), malignant melanoma (Kruger-Krasagakes et al, 1994;Fortis et al, 1996), pancreatic and gastric adenocarcinomas (Kemik et al, 2012;Dummer et al, 1996;Fortis et al, 1996), renal cell carcinoma (MenetrierCaux et al, 1999;Wittke et al, 1999), prostate cancer (Dwivedi et al, 2011, ovarian cancer (Mustea et al, 2009;Zhu et al, 2010;Rabinovich et al, 2010), non-small-cell lung cancer (Zhao et al, 2013a), superficial transitional cell carcinoma of the bladder (Agarwal et al, 2010;Lang et al, 2012), premalignant cervical lesions (Mindiola et al, 2008;Torres-Poveda et al, 2012), various lymphomas (Cortes et al, 1995;Asadullah et al, 1997Asadullah et al, , 2000Cortes and Kurzrock, 1997;Sarris et al, 1999;Vassilakopoulos et al, 2001;Fayad et al, 2001;Nacinović-Duletić et al, 2008;Guney et al, 2009;Labidi et al, 2010;Gaiolla et al, 2011;Purdue et al, 2011;Charbonneau et al, 2012;Gupta et al, 2012;Mellgren et al, 2012), malignant pleural effusions (Klimatsi...…”

High expression of B7-H3 and CD163 in cancer tissues indicates malignant clinicopathological status and poor prognosis of patients with urothelial cell carcinoma of the bladder

“…Although the identification of CD163 + TAM infiltration has been demonstrated to be associated with a poor prognosis in several types of cancer, including UCB (30)(31)(32), CD163 is also expressed by a significant portion of the malignant cells in tumors and lymph nodes (7,21,32,33). Additionally, TAMs were not mechanically divided into M1-type and M2-type phenotype macrophages, as was performed in previous studies (2)(3)(4)(5)(6)(7)(14)(15)(16)(17)(18). Therefore, continued study of the effects of B7-H3 and CD163 + TAM infiltration with other macrophage phenotypes in the progression of UCB are required in larger series and different cohorts.…”

“…Surgical resection is the primary treatment method for patients with muscle-invasive and recurrent non-muscle-invasive UCB. However, metastasis resulted in 90% of incidences of mortality caused by UCB following gradical cystectomy or transurethral resection, the underlying molecular mechanism of which remains poorly understood (2)(3)(4)(5)(6)(7).…”

“…This phenomenon may be partly due to the heterogeneity of TAMs and the tumor microenvironment, particularly the varied nature of immunoregulatory factors. It has been reported that TAMs affect tumor angiogenesis, invasion and patient prognosis in various types of cancer, including bladder cancer (3)(4)(5). TAMs have been divided into two phenotypes: M1.…”

Bladder cancer: what’s new in 2017

“…Получены также доказательства иммуносупрессии при РМП [8][9][10][11][12]. Клетки РМП могут «отключать» инфильтрирующие Т-лимфоциты, создавая иммуносупрессирующее микроокружение и тем самым избегая иммунного надзора.…”