Alterations of DNA Methylation Were Associated with the Rapid Growth of Cortisol-Producing Adrenocortical Adenoma During Pregnancy

Wang, Chuan; Sun, Yujing; Feng, Ruoqi; Feng, Ruiying; Xu, Mingyue; Yin, Xiaofei; Liang, Kai; Zhao, Ruxing; Gu, Gang-Li; Jiang, Xuewen; Su, Peng; Zhang, Xiaofang; Wang, Zhibin

doi:10.2139/ssrn.3930217

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Di Dalmazi and coauthors did not find differences in methylation patterns in 11BHSD1 between these two groups [ 57 ]. Finally, very recently, alterations of DNA methylation were suggested to be possibly associated with the growth and worsening of cortisol secretion in pregnancy [ 58 ].…”

Section: Pathophysiology Of Pituitary and Adrenal Mild Hypercortisolismmentioning

confidence: 99%

Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside

Favero

Cremaschi

Parazzoli

et al. 2022

IJMS

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Mild hypercortisolism is defined as biochemical evidence of abnormal cortisol secretion without the classical detectable manifestations of overt Cushing’s syndrome and, above all, lacking catabolic characteristics such as central muscle weakness, adipose tissue redistribution, skin fragility and unusual infections. Mild hypercortisolism is frequently discovered in patients with adrenal incidentalomas, with a prevalence ranging between 5 and 50%. This high variability is mainly due to the different criteria used for defining this condition. This subtle cortisol excess has also been described in patients with incidentally discovered pituitary tumors with an estimated prevalence of 5%. To date, the mechanisms responsible for the pathogenesis of mild hypercortisolism of pituitary origin are still not well clarified. At variance, recent advances have been made in understanding the genetic background of bilateral and unilateral adrenal adenomas causing mild hypercortisolism. Some recent data suggest that the clinical effects of glucocorticoid (GC) exposure on peripheral tissues are determined not only by the amount of the adrenal GC production but also by the peripheral GC metabolism and by the GC sensitivity. Indeed, in subjects with normal cortisol secretion, the combined estimate of cortisol secretion, cortisone-to-cortisol peripheral activation by the 11 beta-hydroxysteroid dehydrogenase enzyme and GC receptor sensitizing variants have been suggested to be associated with the presence of hypertension, diabetes and bone fragility, which are three well-known consequences of hypercortisolism. This review focuses on the pathophysiologic mechanism underlying both the different sources of mild hypercortisolism and their clinical consequences (bone fragility, arterial hypertension, subclinical atherosclerosis, cardiovascular remodeling, dyslipidemia, glucose metabolism impairment, visceral adiposity, infections, muscle damage, mood disorders and coagulation).

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Section: Pathophysiology Of Pituitary and Adrenal Mild Hypercortisolismmentioning

confidence: 99%

Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside

Favero

Cremaschi

Parazzoli

et al. 2022

IJMS

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show abstract

“…Adrenal adenoma, which often causes infertility owing to ovulatory dysfunction, is rare during pregnancy. Abnormal hormonal secreted from adrenal adenoma would in turn promote the progression of adrenal adenoma, leading to adverse maternal and fetal outcomes which include preeclampsia, hypertensive crisis, hyperglycemia, heart failure and other severe complications [1][2][3] . It's challenge to diagnose and treat the patients without consensus concerning strategy.…”

Section: Introductionmentioning

confidence: 99%

Adrenal Adenoma dignosed during pregnancy: A 20-year experience at a tertiary center

Zhu

Cai

Zhang

et al. 2023

Preprint

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Background Adrenal adenoma during pregnancy is rare and the diagnosis is challenging owing to unspecific symdromes and restricted investigation. It’s poorly described obstetric outcomes of patients underwent surgery during pregnancy or only received medicine treatment. To report the clinical characteristics and obstetric outcomes of pregnant women complicated with adrenal adenoma. Methods A retrospective study was performed. The clinical characteristics, management and obstetric outcome of pregnancies diagnosed as adrenal adenoma over 20 years were reviewed from a teriary hospital. Results A total of 12 women were diagnosed as adrenal adenoma during pregnancy from to January 2000 to September 2022. Eight women had cortisol-secreting adrenal adenoma, two had over-secrete catecholamine and two primary aldosteronism. The original symptoms adrenal adenoma during pregnancy included hypertension or preeclampsia, gestational diabetes mellitus or pre-pregnancy diabetes mellitus, hypokalemia and ecchymosis. There were four women took adrenalectomy during pregnancy, while 8 women only received medicine therapy. Preterm birth occurred in all cases who received medicine, whereas 1 case suffered from preterm birth in the group underwent surgery. Among the 8 women of medicine group, there were 3 neonatal death. Conclusions Once simultaneous onset of hypertension, hyperglycemia and hypokalemia during the 1st or 2nd trimester, adrenal adenoma should be investigate by laboratory examination and imaging examination. The maternal and fetal outcome were unpredictive owing to the severity of adrenal adenoma, particular in patients only received medicine treatment. Adrenalectomy should be recommended during the pregnancy.

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Alterations of DNA Methylation Were Associated with the Rapid Growth of Cortisol-Producing Adrenocortical Adenoma During Pregnancy

Cited by 2 publications

References 20 publications

Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside

Pathophysiology of Mild Hypercortisolism: From the Bench to the Bedside

Adrenal Adenoma dignosed during pregnancy: A 20-year experience at a tertiary center

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