Alterations of EEG functional connectivity in resting state obese and overweight patients with binge eating disorder: A preliminary report

Imperatori, Claudio; Fabbricatore, Mariantonietta; Farina, Benedetto; Innamorati, Marco; Quintiliani, Maria Isabella; Lamis, Dorian A.; Contardi, Anna; Marca, Giacomo Della; Speranza, Anna Maria

doi:10.1016/j.neulet.2015.09.026

Cited by 16 publications

(20 citation statements)

References 51 publications

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“…Out of the seven included studies investigating eight samples, two studies analyzed spectral power in individuals with BN (Léonard, Pepinà, Bond, & Treasure, ; Wolz et al, ), three studies investigated individuals with BED (Imperatori et al, ; Tammela et al, ; Wolz et al, ), and three studies investigated individuals with obesity only (Bauer & Manning, ; Hume, Howells, Karpul, et al, ; Hume, Howells, Rauch, Kroff, & Lambert, ). All characteristics of included studies are summarized in Table .…”

Section: Resultsmentioning

confidence: 99%

“…Two studies investigated adults with BED and co‐morbid obesity (American Psychiatric Association, ; Imperatori et al, ; Tammela et al, ), and one study investigated women with BED across the weight range (Wolz et al, ). In one study, BED was determined via a semistructured expert interview according to Diagnostic and Statistical Manual of Mental Disorders (DSM)‐5 criteria (Wolz et al, ), and two studies (Imperatori et al, ; Tammela et al, ) used a self‐report questionnaire ( Binge Eating Scale [BES]; Gormally, Black, Daston, & Rardin, ). Imperatori et al () derived the resting‐state EEG eyes closed for 5 min at 32 standard positions (10–20 system), after a 4‐ to 6‐hr fast.…”

Section: Resultsmentioning

confidence: 99%

“…In one study, BED was determined via a semistructured expert interview according to Diagnostic and Statistical Manual of Mental Disorders (DSM)‐5 criteria (Wolz et al, ), and two studies (Imperatori et al, ; Tammela et al, ) used a self‐report questionnaire ( Binge Eating Scale [BES]; Gormally, Black, Daston, & Rardin, ). Imperatori et al () derived the resting‐state EEG eyes closed for 5 min at 32 standard positions (10–20 system), after a 4‐ to 6‐hr fast. Tammela et al () derived the EEG from 64 electrode positions (10–20 system) after an overnight fast at resting‐state eyes closed for an unspecified amount of time and at resting‐state eyes open for 15 min each before a neutral control and a food‐cue condition.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Abnormalities in the EEG power spectrum in bulimia nervosa, binge‐eating disorder, and obesity: A systematic review

Blume

Schmidt

Hilbert

2018

Euro Eating Disorders Rev

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To provide a basis for electroencephalography (EEG) neurofeedback protocols for bulimia nervosa (BN), binge‐eating disorder (BED), and obesity, this systematic review investigates alterations in EEG‐measured brain activity, specifically frequency bands. A systematic literature search with predefined search terms yielded N = 7 studies meeting the inclusion criteria. The risk of bias was assessed for all studies. In resting‐state EEG, the beta activity was elevated in fronto‐central regions in individuals with obesity and co‐morbid BED. In food‐cue conditions, both obese individuals with and without BED showed increased beta activity, suggesting increased awareness of food cues and a heightened attentional focus towards food stimuli. The level of beta activity was positively correlated with eating disorder psychopathology in resting and food‐cue conditions. In individuals with BN, there was no evidence for altered EEG spectral power. The results indicate specific alterations in EEG‐based brain activity in individuals with BED and obesity. More high‐quality studies are needed to further confirm these findings and to transfer them into EEG‐based interventions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Abnormalities in the EEG power spectrum in bulimia nervosa, binge‐eating disorder, and obesity: A systematic review

Blume

Schmidt

Hilbert

2018

Euro Eating Disorders Rev

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“…There were no other differences between the groups in the EEG findings, although eating disorders have been reported to be associated with EEG abnormalities in obese patients [45,46]. Furthermore, one study indicated that obese participants without eating disorders showed poor alpha desynchronization [47].…”

Section: Discussionmentioning

confidence: 89%

Relation of insulin resistance to neurocognitive function and electroencephalography in obese children

Akın

Eker

Arslan

et al. 2017

Journal of Pediatric Endocrinology and Metabolism

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Background: Childhood obesity may lead to neuronal impairment in both the peripheral and the central nervous system. This study aimed to investigate the impact of obesity and insulin resistance (IR) on the central nervous system and neurocognitive functions in children. Methods: Seventy-three obese children (38 male and 35 female) and 42 healthy children (21 male and 21 female) were recruited. Standard biochemical indices and IR were evaluated. The Wechsler Intelligence Scale for Children-Revised (WISC-R) and electroencephalography (EEG) were administered to all participants. The obese participants were divided into two groups based on the presence or absence of IR, and the data were compared between the subgroups. Results: Only verbal scores on the WISC-R in the IR+ group were significantly lower than those of the control and IRgroups. There were no differences between the groups with respect to other parameters of the WISC-R or the EEG. Verbal scores of the WISC-R were negatively correlated with obesity duration and homeostatic model assessmentinsulin resistance (HOMA-IR) values. EEGs showed significantly more frequent 'slowing during hyperventilation' (SDHs) in obese children than non-obese children.

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“…Binging usually includes highly palatable foods that are typically characterized by high calorie density and low nutritional values (Oswald et al, 2011; Bekker et al, 2014; Boggiano et al, 2014; Pool et al, 2015) and it is often accompanied by a sense of loss of control in humans (Finlayson et al, 2011; APA, 2013; Boggiano et al, 2014, 2015; Dalton and Finlayson, 2014; Pool et al, 2015) which is triggered by emotional stressors (Boggiano et al, 2007, 2014, 2015; Bello et al, 2014; Pool et al, 2015). Food consumption while binging is not necessarily driven by hunger and therefore it increases various health risks (Finlayson et al, 2011; APA, 2013; Bekker et al, 2014; Boggiano et al, 2015; Imperatori et al, 2015; Pool et al, 2015). Behavioral, emotional, and cognitive properties of BE are seen in 10–20% of the general population (Dalton and Finlayson, 2014).…”

Section: Introductionmentioning

confidence: 99%

A Potential Animal Model of Maladaptive Palatable Food Consumption Followed by Delayed Discomfort

2017

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Introduction: Binging is the consumption of larger amounts of food in a briefer period of time than would normally be consumed under similar circumstances. Binging requires palatable food (PF) to trigger abnormal eating, probably reflecting gene × environment interactions. In this study we examined the impact of trait binge eating (BE) and its compulsive nature on the conflict between hedonic eating of PF and anticipation of a delayed aversive effect. We used female rats as an animal model similar to other models of BE. A novel aspect of this model in this paper is the use of a delayed internal aversive effect produced by lactose ingestion. Establishing this model will allow us to better understand the nature of the conflict between immediate reward and its delayed aversive implications. We hypothesized that BE prone (BEP) rats will demonstrate maladaptive decision making, presenting higher motivation toward PF even when this is associated with delayed discomfort.Method: (Phase 1) 52 female adult Wistar rats were divided to two eating profiles: resistant and prone binge eaters (BER/BEP) based on intake of liquid PF (Ensure). Next, all subjects underwent a Lactose Conditioning Protocol (LCP) that included 4 h tests, one baseline and 3 conditioning days (Phase 2), in which solid PF (Oreo cookies) was paired with glucose (control-no internal aversive effect) or lactose, dissolved in liquid PF. Index for PF motivation was PF consumption during the 4 h LCP. To test for memory of lactose conditioning, we performed another LCP with glucose only (anticipation, but no actual lactose-induced discomfort), a week after the last conditioning session.Results: Lactose conditioned BEP showed higher motivation toward PF compared to lactose conditioned BER faced with delayed aversive effects. Only lactose conditioned BER rats devaluated the PF over LCP days, indicating an association between PF and abdominal discomfort. In addition, only lactose conditioned BER presented an adaptive dynamic behavior, by varying PF intake according to consequences. Furthermore, solid PF consumption was predicted by binge size of liquid PF, only for lactose conditioned rats.Conclusions: We established an animal model for a common eating conflict in humans using delayed internal aversive unconditional stimuli.

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Alterations of EEG functional connectivity in resting state obese and overweight patients with binge eating disorder: A preliminary report

Cited by 16 publications

References 51 publications

Abnormalities in the EEG power spectrum in bulimia nervosa, binge‐eating disorder, and obesity: A systematic review

Abnormalities in the EEG power spectrum in bulimia nervosa, binge‐eating disorder, and obesity: A systematic review

Relation of insulin resistance to neurocognitive function and electroencephalography in obese children

A Potential Animal Model of Maladaptive Palatable Food Consumption Followed by Delayed Discomfort

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