“…At physiologic flow rates these changes in K-absorptive flux would significantly influence the rate of renal K excretion (5). Moreover, the recent demonstration of ouabain-insensitive, omeprazole-sensitive, potassium-activated adenosine triphosphatase (K-ATPase) activity in the CD (6)(7)(8) that is increased in activity in the OMCDi with K depletion (7) provides further indirect evidence that K absorption may proceed via a primary active, luminal K-absorptive pump. Thus, the present study was de-signed to examine the role of proton-potassium-activated adenosine triphosphatase (H-K-ATPase) on proton secretion and K absorption in the OMCDi.…”