1987
DOI: 10.1152/ajprenal.1987.253.3.f408
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Alterations of enzymatic activities along rat collecting tubule in potassium depletion

Abstract: This study was designed to correlate morphological alterations induced in rat collecting tubule by potassium depletion with changes in the activity of enzymatic markers of the cell basolateral membrane. Results show the following responses. 1) Potassium depletion induced a huge and progressive hypertrophy of the outer medullary collecting tubule (MCT). Hypertrophy was paralleled by enhancements of vasopressin- and forskolin-dependent adenylate cyclase (AC) activities. Glucagon-sensitive AC was also increased, … Show more

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Cited by 26 publications
(25 citation statements)
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“…ATPase activity are present in the OMCDj normally and that both may be stimulated by aldosterone. Potassium restriction may act as an additional factor that stimulates the H-K-pump (6). Because the diet used in this study profoundly suppressed plasma aldosterone concentration (5), electrogenic acidification may be small or absent during K restriction as supported by the present data.…”
Section: Discussionsupporting
confidence: 73%
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“…ATPase activity are present in the OMCDj normally and that both may be stimulated by aldosterone. Potassium restriction may act as an additional factor that stimulates the H-K-pump (6). Because the diet used in this study profoundly suppressed plasma aldosterone concentration (5), electrogenic acidification may be small or absent during K restriction as supported by the present data.…”
Section: Discussionsupporting
confidence: 73%
“…Because the diet used in this study profoundly suppressed plasma aldosterone concentration (5), electrogenic acidification may be small or absent during K restriction as supported by the present data. 6 Finally, the lack of any effect of omeprazole on VT and JNa demonstrates that the profound action of omeprazole on both JTCO2 and JK cannot be attributed to nonspecific or toxic effects. An important finding of the present study is that the CD is capable of active K absorption.…”
Section: Discussionmentioning
confidence: 98%
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“…Note that Na-K-ATPase activity in the MCD has also been shown to increase in animals fed a low-K diet (23)(24)(25). If Na-K-ATPase is responsible for K+ conservation during K depletion by increasing K+ reabsorption in the MCD, this enzyme should be present in the apical membrane of K-absorbing cells in this segment.…”
Section: Discussionmentioning
confidence: 96%