Alterations of folliculogenesis in women with polycystic ovary syndrome

Sander, Valeria Analía; Hapon, María Belén; Sícaro, Laura; Lombardi, Eduardo; Jahn, Graciela A.; Motta, Alicia Beatriz

doi:10.1016/j.jsbmb.2011.01.008

Cited by 40 publications

(31 citation statements)

References 43 publications

(45 reference statements)

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“…COX2 expression levels in ovaries of PCOS rats were elevated at both the gene and protein level in our research, and a synchronous increase in the levels of several PGs was also observed. This result contrasts with those of others reporting that the COX2 expression level and PGE concentration were not altered, but PGF2α levels were elevated in follicular fluid and granulosa cells in patients with PCOS after superovulation . This difference might be related to differences in the study objects and interventions.…”

Section: Discussioncontrasting

confidence: 97%

Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats

Huang

Xue

et al. 2018

J Cellular Molecular Medi

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The metabolism of polyunsaturated fatty acids (PUFAs) remains poorly characterized in ovarian tissues of patients with polycystic ovary syndrome (PCOS). This study aimed to explore alterations in the levels of PUFAs and their metabolites in serum and ovarian tissues in a PCOS rat model treated with a high‐fat diet and andronate. Levels of PUFAs and their metabolites were measured using gas/liquid chromatography‐mass spectrometry after the establishment of a PCOS rat model. Only 3 kinds of PUFAs [linoleic acid, arachidonic acid (AA) and docosahexaenoic acid] were detected in both the circulation and ovarian tissues of the rats, and their concentrations were lower in ovarian tissues than in serum. Moreover, significant differences in the ovarian levels of AA were observed between control, high‐fat diet‐fed and PCOS rats. The levels of prostaglandins, AA metabolites via the cyclooxygenase (COX) pathway, in ovarian tissues of the PCOS group were significantly increased compared to those in the controls. Further studies on the mechanism underlying this phenomenon showed a correlation between decreased expression of phosphorylated cytosolic phospholipase A2 (p‐cPLA2) and increased mRNA and protein expression of COX2, potentially leading to a deeper understanding of altered AA and prostaglandin levels in ovarian tissues of PCOS rats.

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Section: Discussioncontrasting

confidence: 97%

Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats

Huang

Xue

et al. 2018

J Cellular Molecular Medi

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“…Only a few studies examined the levels of StAR expression in fresh GLCs from mature follicles from PCOS patients undergoing oocyte aspiration, and the results obtained were contradictory. Sander et al concluded that women with PCOS exhibited enhanced mRNA abundance of StAR when compared with controls (Sander et al, 2011). Paradoxically, they found lower progesterone and estradiol levels than in healthy follicles.…”

Section: Discussionmentioning

confidence: 99%

Altered endothelin expression in granulosa-lutein cells of women with polycystic ovary syndrome

et al. 2012

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“…Vitamin D stimulates the production of oestrogen and progesterone in ovarian tissue while lack of its effect on the production of testosterone may be explained by the increase in the aromatase activity [31]. In PCOS follicles, aromatase gene expression was decreased in comparison to controls, while preovulatory follicles produce higher levels of luteinizing hormone (LH) and lower levels of progesterone and estradiol [32].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D Supplementation on the Androgenic Profile in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials

2017

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It is suggested that vitamin D status is associated with androgenic profile in women with polycystic ovarian syndrome (PCOS). Although several clinical trials are known in this regard, the results were inconsistent. Therefore, this study was aimed to conduct a systematic review and meta-analysis of published clinical trials to elucidate the possible effect of vitamin D supplementation on the androgen levels in adult females with PCOS. PubMed, SCOPUS, and Google Scholar were searched to identify related articles published up to January 2017. Mean ± standard deviation (SD) of changes in serum total testosterone, sex hormone binding globulin (SHBG), and free testosterone were extracted to calculate Hedges' g to be used as effect size for meta-analysis. DerSimonian and Liard random effects model was incorporated to summarize the effects. Six clinical trials with 183 participants aged 18-41 years with follow-up period between 3-24 weeks were included. Our analysis revealed that vitamin D supplementation significantly reduces total testosterone (Hedges' g=-0.32, 95% CI: -0.55 to -0.10; p=0.005); this effect remained significant in single group trials after subgroup analysis. Vitamin D supplementation did not affect serum free testosterone (Hedges' g=-0.21, 95% CI: -0.44 to 0.079; p=0.08) or SHBG levels (Hedges' g=0, 95% CI, 0.22-0.22; p=0.98). The present systematic review and meta-analysis revealed that vitamin D supplementation might significantly affect serum total testosterone while it is not effective in improving other markers of androgenic profile. Future double-blind, placebo-controlled clinical trials are highly recommended.

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Alterations of folliculogenesis in women with polycystic ovary syndrome

Cited by 40 publications

References 43 publications

Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats

Alterations of polyunsaturated fatty acid metabolism in ovarian tissues of polycystic ovary syndrome rats

Altered endothelin expression in granulosa-lutein cells of women with polycystic ovary syndrome

The Effect of Vitamin D Supplementation on the Androgenic Profile in Patients with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Clinical Trials

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