Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications

Tsigalou, Christina; Paraschaki, Afroditi; Bragazzi, Nicola Luigi; Aftzoglou, Konstantina; STAVROPOULOU, Elisaveth; Tsakris, Zacharias; Vradelis, Stergios; Bezirtzoglou, Eugenia

doi:10.3389/fcimb.2023.1191126

Cited by 6 publications

(2 citation statements)

References 126 publications

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“…Surgery can alter the composition of the gut microbiome in the gastrointestinal tract. 32 Therefore, surgery might also impact the gut microbiome composition in the kidney, and some of these changes could be reflected in the blood after surgery.…”

Section: Cutibacterium Acnes-derived Evs Promote Tumor Growth In Vivomentioning

confidence: 99%

Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma

Jingushi,

Kawashima,

Tanikawa

et al. 2024

Cancer Science

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Bacterial flora are present in various parts of the human body, including the intestine, and are thought to be involved in the etiology of various diseases such as multiple sclerosis, intestinal diseases, cancer, and uterine diseases. In recent years, the presence of bacterial 16S rRNA genes has been revealed in blood, which was previously thought to be a sterile environment, and characteristic blood microbiomes have been detected in various diseases. However, the mechanism and the origin of the bacterial information are unknown. In this study, we performed 16S rRNA metagenomic analysis of bacterial DNA in serum extracellular vesicles from five healthy donors and seven patients with renal cell carcinoma and detected Cutibacterium acnes DNA as a characteristic bacterial DNA in the serum extracellular vesicles of patients with renal cell carcinoma. In addition, C. acnes DNA was significantly reduced in postoperative serum extracellular vesicles from patients with renal cell carcinoma compared with that in preoperative serum extracellular vesicles from these patients and was also detected in tumor tissue and extracellular vesicles from tumor tissue‐associated microbiota, suggesting an association between C. acnes extracellular vesicles and renal cell carcinoma. C. acnes extracellular vesicles were taken up by renal carcinoma cells to enhance their proliferative potential. C. acnes extracellular vesicles also exhibited tumor‐promoting activity in a mouse model of renal cancer allografts with enhanced angiogenesis. These results suggest that extracellular vesicles released by C. acnes localized in renal cell carcinoma tissues act in a tumor‐promoting manner.

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Section: Cutibacterium Acnes-derived Evs Promote Tumor Growth In Vivomentioning

confidence: 99%

Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma

Jingushi,

Kawashima,

Tanikawa

et al. 2024

Cancer Science

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“…Clinical studies have shown that factors such as traction during surgery and general anesthesia can result in poor postoperative gastrointestinal function recovery in patients, which not only affects the patients' recovery outcomes but also their quality of life. Additionally, due to the large surgical incision, patients need to use pain pumps, further exacerbating gastrointestinal dysfunction[ 9 ]. For example, common clinical manifestations include cessation of flatulence and bloating, which require surgical intervention for treatment.…”

Section: Introductionmentioning

confidence: 99%

Clinical observation of gastrointestinal function recovery in patients after hepatobiliary surgery

Zeng,

Liu,

Yang

2024

World J Gastrointest Surg

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BACKGROUND The liver is an important metabolic and digestive organ in the human body, capable of producing bile, clotting factors, and vitamins. AIM To investigate the recovery of gastrointestinal function in patients after hepatobiliary surgery and identify effective rehabilitation measures. METHODS A total of 200 patients who underwent hepatobiliary surgery in our hospital in 2022 were selected as the study subjects. They were divided into a control group and a study group based on the extent of the surgery, with 100 patients in each group. The control group received routine treatment, while the study group received targeted interventions, including early enteral nutrition support, drinking water before gas discharge, and large bowel enema, to promote postoperative gastrointestinal function recovery. The recovery of gastrointestinal function was compared between the two groups. RESULTS Compared with the control group, patients in the study group had better recovery of bowel sounds and less accumulation of fluids in the liver bed and gallbladder fossa (P < 0.05). They also had shorter time to gas discharge and first meal (P < 0.05), higher overall effective rate of gastrointestinal function recovery (P < 0.05), and lower incidence of postoperative complications (P < 0.05). CONCLUSION Targeted nursing interventions (early nutritional support, drinking water before gas discharge, and enema) can effectively promote gastrointestinal function recovery in patients undergoing hepatobiliary surgery and reduce the incidence of complications, which is worthy of promotion.

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The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective

Huang,

Qin,

et al. 2024

Mol Neurobiol

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Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the financial burden on patients. With an increasing number of surgical procedures being performed, the prevention and management of perioperative neurocognitive dysfunction have garnered significant attention. While factors such as age, lifestyle, genetics, and education are known to influence the development of cognitive dysfunction, recent research has highlighted the role of the gut microbiota in neurological health. An increased abundance of pro-inflammatory gut microbiota can trigger and worsen neuroinflammation, neuronal cell damage, and impaired cellular autophagy. Moreover, the inflammation-promoting gut microbiota can disrupt immune function, impair neuroautophagy, and affect the production and circulation of extracellular vesicles and neurotransmitters. These factors collectively play a role in the onset and advancement of cognitive impairment. This narrative review delves into the molecular mechanisms through which gut microbiota and their derivatives contribute to cognitive impairment, focusing on the impact of anesthesia surgery, changes in gut microbial populations, and perioperative cognitive impairment associations. The study suggests that alterations in the abundance of various bacterial species and their metabolites pre- and post-surgery may be linked to postoperative cognitive impairment. Furthermore, the potential of probiotics or prebiotics in addressing cognitive impairment is discussed, offering a promising avenue for investigating the treatment of perioperative neurocognitive disorders.

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Alterations of gut microbiome following gastrointestinal surgical procedures and their potential complications

Cited by 6 publications

References 126 publications

Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma

Cutibacterium acnes‐derived extracellular vesicles promote tumor growth in renal cell carcinoma

Clinical observation of gastrointestinal function recovery in patients after hepatobiliary surgery

The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective

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