Alterations of immunoglobulin G and immunoglobulin M levels in the breast milk of mothers with exclusive breastfeeding compared to mothers with non‐exclusive breastfeeding during 6 months postpartum: The Jordanian cohort study

Abuidhail, Jamila; Al‐Shudiefat, Abd Al‐Rahman; Darwish, Mona

doi:10.1002/ajhb.23197

Cited by 11 publications

(17 citation statements)

References 14 publications

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“…Additionally, the latest reports of Goonatilleke et al (15) showed the gradual decrease in IgM concentration from the beginning of lactation until 6 months. Similar results were presented by Abuidhail et al (21), who showed that the IgM concentration in milk samples from the 1st month of lactation was significantly higher (103 ± 31 mg/L) than for the 4th and the 6th month of lactation (64 ± 25 and 48 ± 18 mg/L, respectively) (21). Moreover, the concentration of IgM from the 2nd to the 6th day of lactation was positively associated with overweight and obesity of the mother before pregnancy as well as with primiparity and negatively associated with smoking during pregnancy (22).…”

Section: Introductionsupporting

confidence: 92%

“…These values are consistent with that of about 20 mg/L given by Broadhurst et al (19) for the same lactation period and lower than that established by Koenig et al (20) for early colostrum of term (54 ± 37 mg/L) and preterm birth (very preterm, 76 ± 38 mg/L; moderately preterm, 47 ± 42 mg/L). On the other hand, the report of Abuidhail et al (21) showed that the IgG concentration in milk samples derived from the 1st month of lactation was significantly lower (103 ± 41 mg/L) than that for the 4th and 6th month of lactation (133 ± 49 and 145 ± 54 mg/L, respectively), although the values were higher than previously reported.…”

Section: Introductioncontrasting

confidence: 56%

“…For this purpose, sensitive methods such as ELISA with very specific antibodies adopted to meet the requirements of working with milk samples, was used. Until now, particular immunoglobulin profile studies have been limited usually up to 6 months of lactation ( 14 , 20 ) only, or if it was studied for a longer period of lactation, a small number of milk samples were analyzed ( 15 – 17 , 21 ).…”

Section: Discussionmentioning

confidence: 99%

“…Not only the frequency of feeding but also the way of feeding may affect the concentration of immunoglobulins. Abuidhail et al ( 21 ) showed that the type of feeding has an impact on IgG concentration, namely, in exclusively breastfeeding mothers' milk the concentration of IgG was higher than in non-exclusively breastfeeding mothers' milk, but the level of IgM was not affected ( 21 ). Abuidhail et al ( 21 ) also suggested that more time during breastfeeding and a greater volume of milk given to the babies ensure more immunoglobulin IgG and IgM because a greater breast milk volume contains more Igs.…”

Section: Discussionmentioning

confidence: 99%

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Changes in Human Milk Immunoglobulin Profile During Prolonged Lactation

et al. 2020

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Mother's milk immunoglobulins (Igs) delivered to infants during breastfeeding are crucial in shaping and modulating immature infants' immune system and provide efficient protection against pathogens. The aim of the study was to evaluate the immunoglobulin concentrations in milk of 116 lactating mothers over prolonged lactation from the 1st to the 48th month using the ELISA method. The concentration of proteins, SIgA and IgG, but not IgM, showed a positive correlation (r = 0.69, p < 0.005; r = 0.54, p < 0.05; and r = 0.27, p < 0.05, respectively) with lactation from the 1st to the 48th month. The lowest concentrations of SIgA and IgG were observed for the first year (2.12 ± 0.62 g/L and 14.71 ± 6.18 mg/L, respectively) and the highest after the 2nd year of lactation (7.55 ± 7.16 g/L and 18.95 ± 6.76 mg/L, respectively). The IgM concentration remained stable during 2 years (2.81 ± 2.74 mg/L), but after 24 months it was higher (3.82 ± 3.05 mg/L), although not significantly. Moreover, negative correlations of protein (r = −0.24, p < 0.05) and SIgA (r = −0.47, p < 0.05) concentrations with the number of feedings were found. Human milk after the 2nd year of lactation contains significantly higher concentrations of protein, SIgA, and IgG. High concentration of immunoglobulins and protein during prolonged lactation is an additional argument to support breastfeeding even after introducing solid foods and should be one of the overarching goals in the protection of children's health.

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Section: Introductionsupporting

confidence: 92%

Section: Introductioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Changes in Human Milk Immunoglobulin Profile During Prolonged Lactation

et al. 2020

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“…The titer of SARS-CoV-2 RBD-specific IgA (AUC/mg of IgA) was higher in the serum group than the human milk group. The concentrations of IgA, IgM, and IgG in human milk [6][7][8][26][27][28][29] and serum samples 5 were in the ranges found in previous studies. Some women had greater antibody levels in human milk or serum samples than other women.…”

Section: Discussionsupporting

confidence: 77%

Comparison of Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies' Binding Capacity Between Human Milk and Serum from Coronavirus Disease 2019-Recovered Women

Demers‐Mathieu

DaPra

Medo

2021

Breastfeeding Medicine

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Background: Human milk from coronavirus disease 2019 (COVID-19)-recovered women may be useful as oral antibody therapy to prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and provide long-term immunity to neonates and young children. As convalescent plasma is already used as antibody therapy, this study aimed to compare the binding capacity of antibodies specific to the receptorbinding domain (RBD) of SARS-CoV-2 between human milk and serum from COVID-19-recovered women. Materials and Methods: The areas under the curve (AUCs) for IgA, IgM, and IgG specific to the SARS-CoV-2 RBD in human milk and serum samples were measured using enzyme-linked immunosorbent assay. Milk samples were collected from 12 COVID-19-recovered women, while serum samples were from 10 COVID-19recovered women. The antibody concentrations were also determined. Results: Our study reveals that SARS-CoV-2 RBD-specific antibody titers differed between human milk and serum samples from COVID-19-recovered women. When the AUCs were not divided by the antibody concentration, SARS-CoV-2 RBD-specific IgA, IgM, and IgG levels were higher in the serum sample group than the human milk group ( p < 0.001). However, the titers of SARS-CoV-2 RBD-specific IgM (AUC/lg of IgM) and IgG (AUC/lg of IgG) were higher in human milk samples than serum samples ( p < 0.05). The titer of SARS-CoV-2 RBD-specific IgA (AUC/mg of IgA) was higher in the serum sample group than the human milk group ( p < 0.01). Conclusions: Human milk antibodies specific to the RBD of SARS-CoV-2 must be purified to obtain comparable binding capacity observed with SARS-CoV-2 RBD-specific serum antibodies.

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Exploring the effects of weaning age on adult infectious disease mortality among 18th–19th century Italians

Smith

Reitsema

Fornaciari

et al. 2023

American J Hum Biol

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Objectives: The developmental origins of health and disease (DOHaD) hypothesis describes how early childhood stress affects morbidity and mortality later in life. The role of early childhood stress in mortality from infectious disease is understudied. Stressors in early childhood that weaken the immune system may result in increased susceptibility to infectious disease in adulthood. Weaning is one of the earliest potential periods of significant stress in early childhood. This research investigates the effect of weaning after $6 months of age on cholera mortality among 18th-19th-century Italian populations by determining if earlier breastfeeding cessation is associated with earlier mortality, analyzing childhood dietary variation and physiological stress markers, and determining if age-at-weaning completion differs between catastrophic and attritional populations.Methods: Serial dentin stable carbon and nitrogen isotope analyses from canines are compared between catastrophic (n = 45) and attritional groups (n = 23). Canines are sectioned serially from crown to apex, and the increment's δ 15 N and δ 13 C are used to estimate age-at-weaning completion.Results: Catastrophic and attritional groups exhibit similar age-at-weaning completion ($2.8 years). Seventy-four percent of individuals lack elevated δ 15 N values in dentin that formed during infancy.Conclusions: Age-at-weaning completion was not a predisposing factor in cholera mortality in adulthood in this sample. Age-at-weaning completion may not be significantly associated with infectious disease mortality because weaning completion likely occurred after infants had adapted to consuming contaminated weanling foods. Individuals without detectable weaning curves may represent infants who received supplementary foods since birth or were weaned before the age of 6-9 months.

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Alterations of immunoglobulin G and immunoglobulin M levels in the breast milk of mothers with exclusive breastfeeding compared to mothers with non‐exclusive breastfeeding during 6 months postpartum: The Jordanian cohort study

Cited by 11 publications

References 14 publications

Changes in Human Milk Immunoglobulin Profile During Prolonged Lactation

Changes in Human Milk Immunoglobulin Profile During Prolonged Lactation

Comparison of Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies' Binding Capacity Between Human Milk and Serum from Coronavirus Disease 2019-Recovered Women

Exploring the effects of weaning age on adult infectious disease mortality among 18th–19th century Italians

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