Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder

Shen, He; Liu, Xiaohua; Jiang, Kaida; Peng, Daihui; Wu, Hong; Fang, Yiru; Qian, Yuxin; Yu, Shunying; Li, Huafang

doi:10.1016/j.jpsychires.2016.03.015

Cited by 83 publications

(63 citation statements)

References 44 publications

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“…Thus, our finding that miR‐124 overexpression prevents chronic stress‐induced dendritic atrophy and spine loss in the dentate gyrus suggests that downregulation of hippocampal miR‐124 pathways is a causal mechanism underlying aberrant dendritic remodeling induced by chronic stress. Clinical studies have also reported altered expression of miR‐124 in patients with MDD . Our studies and the results of others provide strong evidence for a role for miRNA in depression and show that chronic stress and clinical antidepressants alter miRNA expression.…”

Section: Non‐coding Rna In Stress Responses and Depressionsupporting

confidence: 79%

“…Clinical studies have also reported altered expression of miR-124 in patients with MDD. 151,152 Our studies and the results of others provide strong evidence for a role for miRNA in depression and show that chronic stress and clinical antidepressants alter miRNA expression. Thus, another novel therapeutic strategy for depression may involve direct manipulation of miRNA pathways.…”

Section: Non-coding Rna In Stress Responses and Depressionsupporting

confidence: 61%

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Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida

Yamagata

Seki

et al. 2017

Psychiatry Clin Neurosci

133

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Major depressive disorder is one of the most common mental illnesses as it affects more than 350 million people globally. Major depressive disorder is etiologically complex and disabling. Genetic factors play a role in the etiology of major depression. However, identical twin studies have shown high rates of discordance, indicating non‐genetic mechanisms as well. For instance, stressful life events increase the risk of depression. Environmental stressors also induce stable changes in gene expression within the brain that may lead to maladaptive neuronal plasticity in regions implicated in disease pathogenesis. Epigenetic events alter the chromatin structure and thus modulate expression of genes that play a role in neuronal plasticity, behavioral response to stress, depressive behaviors, and response to antidepressants. Here, we review new information regarding current understanding of epigenetic events that may impact depression. In particular, we discuss the roles of histone acetylation, DNA methylation, and non‐coding RNA. These novel mechanisms of action may lead to new therapeutic strategies for treating major depression.

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Section: Non‐coding Rna In Stress Responses and Depressionsupporting

confidence: 79%

Section: Non-coding Rna In Stress Responses and Depressionsupporting

confidence: 61%

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida

Yamagata

Seki

et al. 2017

Psychiatry Clin Neurosci

133

View full text Add to dashboard Cite

show abstract

“…MiR-124 also inhibits lung tumorigenesis caused by K-ras mutation and NNK (Jin et al, 2017a). MiR-124 is involved in major depressive disorder (He et al, 2016;Fang et al, 2018). MiR-124 can suppress tumorigenesis in mice by silencing gene PTB1 (Taniguchi et al, 2015).…”

Section: Mir-124 Is Associated With Some Serious Diseasesmentioning

confidence: 99%

“…MiR-124 is a member of the miRNA family and has common characteristics of miRNAs. Three pre-miR-124 variants (miR-124a or miR-124-1, miR-124-2 and miR-124-3) produce the same mature miRNA (He et al, 2016). MiR-124 is an evolutionarily conserved, noncoding microRNA in organisms.…”

Section: Introductionmentioning

confidence: 99%

“…MiR-124 is an evolutionarily conserved, noncoding microRNA in organisms. In humans and rats, miR-124 is most abundant in the brain, and many diseases of the brain are associated with abnormal levels of miR-124 (He et al, 2016;Taniguchi et al, 2015). Over the years, many studies have focused on the role of miR-124 in the nervous system Sun et al, 2015), cardiovascular diseases (Bao et al, 2017), apoptosis .…”

Section: Introductionmentioning

confidence: 99%

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MiR-124 involvement of apoptosis, immunity and regulator of diseases

Sun¹,

Huang²,

Yu³

et al. 2020

Afr. J. Biotechnol.

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Most microRNAs (miRNAs) are noncoding, conserved RNA molecules in vertebrates, and their roles are similar and very important. MiRNAs usually have tissue-specific expression, and abnormal levels of miRNAs have been associated with diseases and have been used as disease biomarkers. MiRNAs are widely involved in biological processes by regulating target mRNAs. MiR-124 is one of the best studied miRNAs in organisms. By targeting different mRNAs, miR-124 plays important roles in the central nervous system, cellular infiltration, pathophysiological processes of cardiovascular diseases, inflammation, immunity and tolerance, etc. This review mainly focuses on tissue-specific or abnormal expression of miR-124 as a biomarker and on the ways miR-124 for the treatment of serious diseases such as cancers.

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Alterations in circulating extracellular vesicles underlie social stress‐induced behaviors in mice

et al. 2021

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Chronic stress induces peripheral and intracerebral immune changes and inflammation, contributing to neuropathology and behavioral abnormalities relevant to psychiatric disorders such as depression.Although the pathological implication of many peripheral factors such as pro-inflammatory cytokines, hormones, and macrophages has been demonstrated, the roles of circulating extracellular vesicles (EVs) for chronic stress mechanisms remain poorly investigated. Here we report that chronic social defeat stress (CSDS)-induced social avoidance phenotype, assessed by a previously untested threechamber social approach test, can be distinguished by multiple pro-inflammatory cytokines and EVassociated molecular signatures in the blood. We found that the expression patterns of miRNAs distinguished the CSDS-susceptible mice from the CSDS-resilient mice. Social avoidance behavior scores were also estimated with good accuracy by the expression patterns of multiple EV-associated miRNAs. We also demonstrated that EVs enriched from the CSDS-susceptible mouse sera upregulated the production of pro-inflammatory cytokines in the LPS-stimulated microglia-like cell lines. Our results indicate the role of circulating EVs and associated miRNAs in CSDS susceptibility, which may be related to pro-inflammatory mechanisms underlying stress-induced neurobehavioral outcomes.

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Alterations of microRNA-124 expression in peripheral blood mononuclear cells in pre- and post-treatment patients with major depressive disorder

Cited by 83 publications

References 44 publications

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

MiR-124 involvement of apoptosis, immunity and regulator of diseases

Alterations in circulating extracellular vesicles underlie social stress‐induced behaviors in mice

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