Alterations of novelty processing in major depressive disorder

Francis, Ashley M.; Bissonnette, Jenna N.; Hull, Krista M.; Leckey, Jennifer; Pimer, Laura; Berrigan, Lindsay; Fisher, Derek J.

doi:10.1016/j.jadr.2021.100083

Cited by 4 publications

(7 citation statements)

References 68 publications

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“…Attentional allocation, evaluative processing, context update, and inhibitory control have all been linked to the P300. As a result, the lower P300 amplitude in depression is consistent with the observed attentional and cognitive impairments commonly seen in MDD [1,6].…”

Section: Introductionsupporting

confidence: 80%

“…Symptoms of MDD include a persistent depressed mood, loss of interest or pleasure, significantly reduced processing speed, working memory, and sustained attention. [1] The pathophysiological pathways that underpin depression are poorly understood. Neurocognitive impairments, such as episodic memory and executive function deficits, have increased depression severity [3].…”

Section: Introductionmentioning

confidence: 99%

“…Depression is the world's most common cause of disability, impacting nearly 250 million people of all ages [ 1 , 2 ]. Depression can manifest itself in various ways, leading to a clinical diagnosis of major depressive disorder (MDD).…”

Section: Introductionmentioning

confidence: 99%

“…Symptoms of MDD include a persistent depressed mood, loss of interest or pleasure, significantly reduced processing speed, working memory, and sustained attention. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

“…Neurocognitive impairments, such as episodic memory and executive function deficits, have increased depression severity [ 3 ]. Individuals with MDD frequently have impaired processing speed and working memory [ 1 ]. These impairments are prevalent depressive symptoms that add to the burden of depression.…”

Section: Introductionmentioning

confidence: 99%

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Assessing Neurocognition (P300) and Correlating Them to Depression Rating Scales in Patients With Major Depressive Disorder

Wakode¹,

Hulke²,

Wakode³

et al. 2022

Cureus

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Background: Major depression is a chronic condition that may affect cognition. Cognitive disturbances may affect clinical scales used to assess the severity of depression.Aims: To find an association between cognitive disturbance as objectively recorded using event-related potentials (P300) with the Hamilton rating scale for depression (HAM-D) and Montgomery-Asberg depression rating scale (MADRS) in newly diagnosed cases of major depression.Methods and material: A cross-sectional study with a sample size of 46 diagnosed cases of major depression. The assessment was done using the HAM-D and MADRS. The P300 assessment was done with the auditory oddball paradigm using the Nihon Kohden NCV-SMG-EP system (Tokyo, Japan).Statistical analysis: Pearson correlation analysis was used to study the association between various parameters of P300 and the HAM-D and MADRS depression rating scales.Results: A significant correlation was found between A21-P300 amplitude Cz and the MADRS score. No significant correlation was seen between other P300 parameters and HAM-D and MADRS scales.Conclusions: As the results were objectively recorded using various parameters of event-related potentials (P300), cognitive impairment was not significantly associated with depression rating scales i.e., the HAM-D and MADRS scores.

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Section: Introductionsupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Symptoms of MDD include a persistent depressed mood, loss of interest or pleasure, significantly reduced processing speed, working memory, and sustained attention. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Assessing Neurocognition (P300) and Correlating Them to Depression Rating Scales in Patients With Major Depressive Disorder

Wakode¹,

Hulke²,

Wakode³

et al. 2022

Cureus

View full text Add to dashboard Cite

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Measuring the attention networks and quantitative-electroencephalography correlates of attention in depression

Francis

Bissonnette

Hull

et al. 2023

Psychiatry Research: Neuroimaging

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Robust single‐trial event‐related potentials differentiate between distress and fear disorders

Randau,

Reinholt,

Pernet

et al. 2023

Psychophysiology

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Recent evidence indicates that measures of brain functioning as indexed by event‐related potentials (ERPs) on the electroencephalogram align more closely to transdiagnostic measures of psychopathology than to categorical taxonomies. The Hierarchical Taxonomy of Psychopathology (HiTOP) is a transdiagnostic, dimensional framework aiming to solve issues of comorbidity, symptom heterogeneity, and arbitrary diagnostic boundaries. Based on shared features, the emotional disorders are allocated into subfactors Distress and Fear. Evidence indicates that disorders that are close in the HiTOP hierarchy share etiology, symptom profiles, and treatment outcomes. However, further studies testing the biological underpinnings of the HiTOP are called for. In this study, we assessed differences between Distress and Fear in a range of well‐studied ERP components. In total, 50 patients with emotional disorders were divided into two groups (Distress, N = 25; Fear, N = 25) according to HiTOP criteria and compared against 37 healthy comparison (HC) subjects. Addressing issues in traditional ERP preprocessing and analysis methods, we applied robust single‐trial analysis as implemented in the EEGLAB toolbox LIMO EEG. Several ERP components were found to differ between the groups. Surprisingly, we found no difference between Fear and HC for any of the ERPs. This suggests that some well‐established results from the literature, e.g., increased error‐related negativity in OCD, are not a shared neurobiological correlate of the Fear subfactor. Conversely, for Distress, we found reductions compared to Fear and HC in several ERP components across paradigms. Future studies could utilize HiTOP‐validated psychopathology measures to more precisely define subfactor groups.

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Alterations of novelty processing in major depressive disorder

Cited by 4 publications

References 68 publications

Assessing Neurocognition (P300) and Correlating Them to Depression Rating Scales in Patients With Major Depressive Disorder

Assessing Neurocognition (P300) and Correlating Them to Depression Rating Scales in Patients With Major Depressive Disorder

Measuring the attention networks and quantitative-electroencephalography correlates of attention in depression

Robust single‐trial event‐related potentials differentiate between distress and fear disorders

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