Alterations of Nutritional Status in Childhood Acute Leukemia

Maldonado-Alcázar, Alejandra; Núñez-Enríquez, Juan Carlos; García-Ruiz, Carlos Alberto; Fajardo-Gutiérrez, Arturo; Mejı́a-Aranguré, Juan Manuel

doi:10.5772/52715

Cited by 5 publications

(9 citation statements)

References 51 publications

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“…Some conclude that there is a significant relation between these factors whereas others conclude that there is no correlation. 1,4,9 The study from St Jude 10 evaluating body mass index and its relationship to dosing did not find any difference in outcome for patients with ALL. Maldonado-Alca ´zar et al 9 and Sala et al 11 have made a correlation of poorer survival outcomes and treatment-related toxicity (TRT) for those who are underweight at diagnosis.…”

mentioning

confidence: 98%

Nutritional Status As a Prognostic Indicator for Pediatric Malignancies

Rogers

2014

JCO

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confidence: 98%

Nutritional Status As a Prognostic Indicator for Pediatric Malignancies

Rogers

2014

JCO

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“…Nutrition status in children with ALL undergoing chemotherapy treatment experienced changes during treatment and was associated with a phase of chemotherapy treatment that was being undertaken (Wolley, Gunawan & Warouw, 2016). There are several factors that cause malnutrition in children with cancer include tumor-specific factors, factors relating to patients and factors related to treatment (Alcazar, et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…This is in accordance with the researchers' assumption that children with ALL who have good nutritional status pre-chemotherapy then the possibility of post-chemotherapy toxicity experienced will be smaller. This is because a good nutritional status can increase the CD4 value and increase the immune system's defense against infectious processes and quality of life will be better than patients with poor nutritional status (Alcazar, et al, 2013;Miftahurachman & Wisaksana, 2015).…”

Section: Discussionmentioning

confidence: 99%

“…Nutritional status is associated with short-term and long-term adverse effects after chemotherapy treatment in children with ALL (Owens, Hanson, McArthur & Mikhailov, 2013). In addition nutritional status associated with the occurrence of relapse, increased free survival event (EFS) and the occurrence of treatment related toxicity (TRT) and disability (Orgel, Sposto, Malvar, Seibel, Ladas, et al,2014;Sari, Windiastuti, Cempako & Devaera, 2010;Alcazar, Enriquez, Ruiz, Gutierrez, & Arangure, 2013). So it is said that the assessment and intervention of nutritional status in children with ALL can improve the quality of life, reduced toxicity and increase survival rate (Hazarika & Dwivedi, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Correlation between Nutritional States with Hematological Toxicity in Children with Acute Lymphoblastic Leukemia

Puspita

Mediani

Nurhidayah

2018

JPKI

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ABSTRAKStatus gizi pada anak dengan acute lymphoblastic acute (ALL) diketahui dapat mempengaruhi efek samping yang mungkin timbul setelah dilakukan kemoterapi. Salah satu efek samping yang sering terjadi pada anak dengan ALL pasca kemoterapi adalah hematological toxicity. Hematological toxicity adalah efek toksik yang ditimbulkan dari obat kemoterapi yang menyebabkan gangguan pada sel darah yang bila tidak diatasi dengan baik dapat menimbulkan kematian. Hematological toxicity sering terjadi pada anak ALL pasca kemoterapi namun belum menjadi perhatian tenaga kesehatan terutama perawat. Tujuan penelitian ini adalah ingin mengetahui hubungan antara status gizi dengan hematological toxicity pada anak ALL yang sedang menjalani kemoterapi. Penelitian ini dilakukan di RSUP Dr Hasan Sadikin Bandung pada bulan Desember 2016 dengan metode penelitian korelasi dengan pendekatan retrospektif. Penelitian ini dilakukan pada 198 responden yang diambil dari catatan rekam medis bulan Januari-Juli 2016 dengan menggunakan purposive sampling. Analisa data menggunakan uji Korelasi Spearman Rank (Rho). Hasil penelitian didapatkan 13 dari 17 responden berstatus gizi sangat kurus mengalami hematological toxicity dan terdapat hubungan yang signifikan antara status gizi dengan hematological toxicity pada anak ALL (p=0,015) dengan korelasi yang sangat lemah (r=-0,172). Kesimpulan: Terdapat hubungan antara status gizi dengan hematological toxicity pasca kemoterapi pada anak LLA yang menjalani kemoterapi. Oleh karena itu, pentingnya pengkajian status gizi dan monitoring tanda-tanda hematological toxicity untuk mencegah terjadinya efek buruk akibat dari pengobatan kemoterapi pada anak dengan ALL. ABSTRACTAcute lymphoblastic leukemia (ALL) is the most common cancer in children and one of the leading causes of death in children. Many factors affect the prognosis of acute lymphoblastic leukemia, one of which is the nutritional status. Nutrition status in children with acute lymphoblastic acute is known to affect side effects that arise after chemotherapy. One of the side effects which often occur in children with ALL post chemotherapy was hematological toxicity. Hematological toxicity was one of the side effect chemotherapy if not treated properly can caused death. The aimed of this research was to analyze the correlation of nutritional status with hematological toxicity on children with ALL in chemotherapy. This study was done in Hasan Sadikin General Hospital in Bandung in December 2016 with correlational research was performed with retrospective approach. 198 respondents were selected using purposive sampling taken from medical records during January-July in 2016. Data was analyzed using Spearman Rank Correlation Test (Rho). The study showed that 17 children with ALL were categorized in very thin (86,7%) suffered from hematological toxicity thus discovered significant correlation between nutritional status pre chemotherapy and hematological toxicity post chemotherapy in children with ALL (p=0,015) for a very weak correlation (r=-0,172). The conclusion in this study researched was that nutritional stated chemotherapy was correlated with hematological toxicity after chemotherapy in children with ALL. Therefore, assessment of nutritional status in children with acute lymphoblastic leukemia should be done especially when chemotherapy treatment is being taken to minimize the occurrence of hematological toxicity

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“…Among the factors that could impact on childhood ALL prognosis, nutritional status has been investigated [12]. Importantly, overweight and obesity at the time of diagnosis have been associated to a high risk of relapse and death in children with ALL [3, 13, 14].…”

Section: Introductionmentioning

confidence: 99%

Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study

et al. 2019

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Background Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood overweight and obesity are reaching epidemic proportions. They have been associated with poor outcomes in children with ALL. The aim of present study was to identify if overweight and obesity are predictors of early mortality and relapse in Mexican children with ALL. Methods A multicenter cohort study was conducted. ALL children younger than 15 years old were included and followed-up during the first 24 months after diagnosis. Overweight and obesity were classified according World Health Organization (WHO) and Centers for Disease Control and Prevention (CDC) criteria. Early mortality and early relapses were the main outcomes. Results A total of 1070 children were analyzed. Overweight/obesity at diagnosis were predictors of early mortality (WHO: HR = 1.4, 95%CI:1.0–2.0; CDC: HR = 1.6, 95%CI:1.1–2.3). However, no associations between overweight (WHO: HR = 1.5, 95%CI:0.9–2.5; CDC: HR = 1.0; 95% CI:0.6–1.6) and obesity (WHO: HR = 1.5, 95%CI:0.7–3.2; CDC: HR = 1.4; 95%CI:0.9–2.3) with early relapse were observed. Conclusions Overweight and obese patients embody a subgroup with high risk of dying during leukemia treatment. Electronic supplementary material The online version of this article (10.1186/s12885-019-5878-8) contains supplementary material, which is available to authorized users.

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Alterations of Nutritional Status in Childhood Acute Leukemia

Cited by 5 publications

References 51 publications

Nutritional Status As a Prognostic Indicator for Pediatric Malignancies

Nutritional Status As a Prognostic Indicator for Pediatric Malignancies

Correlation between Nutritional States with Hematological Toxicity in Children with Acute Lymphoblastic Leukemia

Overweight and obesity as predictors of early mortality in Mexican children with acute lymphoblastic leukemia: a multicenter cohort study

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