Alterations of plasma free amino acids in nephrotic syndrome

El-Gayar, Amal M.; Sobh, Mohamed; Elkholy, Ayman; Sallam, Salem A.; Ew, Wafa

doi:10.1007/bf02767728

Cited by 6 publications

(7 citation statements)

References 8 publications

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“…Similar to what has been described in other studies of human CKD, dogs with PLN had significantly lower leucine, tyrosine, and threonine concentrations, as compared to healthy controls . However, there were several dissimilarities between our findings and these studies, as well as people with nephrotic syndrome in which there are significantly higher concentrations of NEAA, glutamic acid, hydroxyproline and alanine . In people with CKD, low histidine concentrations are associated with PEW, inflammation, oxidative stress, and decreased survival …”

Section: Discussionsupporting

confidence: 87%

“…Without adequate concentrations of EAA, animals cannot meet physiologic demands for protein synthesis, thus contributing to decreased albumin concentrations, impaired immune function, and loss of lean muscle mass. In addition to measuring absolute plasma concentrations, ratios comparing EAA and NEAA have been used in people to assess AA status . The alterations in AA in CKD are because of alterations in nitrogen metabolism, tubular filtration, reabsorption, and excretion as well as increased inflammation …”

Section: Introductionmentioning

confidence: 99%

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Amino acid status in dogs with protein‐losing nephropathy

Parker

Fascetti

Klamer

2019

Veterinary Internal Medicne

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Background Proteinuria in dogs with kidney disease can contribute to protein‐energy wasting and malnutrition. Little is known about amino acid (AA) status in dogs with protein‐losing nephropathy (PLN). Objectives The purpose of our study was to further elucidate AA status in PLN dogs, with the hypothesis that PLN dogs would have altered AA status as compared to healthy dogs. Animals Thirty client‐owned PLN dogs were compared to 10 healthy control dogs. Methods Prospective observational study. Dogs with PLN that were presented to the teaching hospital were enrolled. Plasma AA profiles were measured using an automated high‐performance liquid chromatography AA analyzer. Results Compared to control dogs, PLN dogs had significantly lower concentrations of leucine, threonine, histidine, glycine, proline, asparagine, tyrosine, o‐hydroxyproline, and serine, as well as sums of both essential and nonessential AA (P < .05). Dogs with PLN had significantly lower ratios of tyrosine‐to‐phenylalanine and glycine‐to‐serine (P < .05), and a significantly greater ratio of valine‐to‐glycine (P < .05). Conclusions and Clinical Importance Dogs with PLN have altered AA status compared to healthy dogs. These findings could have therapeutic implications in determining optimal management of PLN dogs, such as providing AA supplementation along with other standard treatment.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Amino acid status in dogs with protein‐losing nephropathy

Parker

Fascetti

Klamer

2019

Veterinary Internal Medicne

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“…The kidneys have a vital role in homeostasis, metabolism, and regulation of the serum concentration of amino acids. Glutamic acid is one of them, and it is correlated with kidney production as well as the accumulation as a result of decreased renal uptake [ 43 , 44 , 45 ]. In human medicine it was increased in patients with normal serum creatinine, but with some early impairment of renal function.…”

Section: Discussionmentioning

confidence: 99%

“…In human medicine it was increased in patients with normal serum creatinine, but with some early impairment of renal function. The authors suggested that this metabolite may be utilized as a future biomarker for early stages of CKD [ 44 ]. We observed a strong correlation between glutamic acid accumulation and the second stage of CKD in this study.…”

Section: Discussionmentioning

confidence: 99%

Serum Metabolites Characterization Produced by Cats CKD Affected, at the 1 and 2 Stages, before and after Renal Diet

et al. 2022

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Utilizing metabolomics, a tool for measuring and characterizing low-molecular-weight substances (LMWs), to identify eventual changes in response to dietary intervention is novel in cats with chronic kidney disease (CKD), a condition characterized by retention of uremic solutes. This study aims to assess the serum metabolomic profile of cats in early stages of CKD and to compare the serum metabolomic of CKD cats after 60 days of a renal diet to evaluate the effect of dietary intervention on these metabolites. Twenty-five domestic cats were included in the study. Fifteen cats with CKD stages 1 (n = 6) and 2 (n = 9) according to the International Renal Interest Society (IRIS) were included in the renal groups, and a control group consisting of 10 cats was included. All animals were enrolled on a maintenance diet for 30 days before the experimental period. The metabolomics analysis was performed by gas chromatography-mass spectrometry (GC-MS). Partial least squares discriminant analysis (PLS-DA) was performed on Metaboanalyst 4.0 software. Forty-three metabolites were identified. Citric acid and monostearin were altered in the CKD2 group when compared to CKD1 and the control group at T0. A total of seven serum metabolites differed after 60 days of the renal diet: glycine, fructose, glutamic acid, arachidonic acid, stearic acid, creatinine, and urea. Changes were seen in the serum metabolomic profile after 60 days of the renal diet, and some of the metabolites that changed in response to the diet have beneficial effects on health. Overall, metabolomics markers have the potential to identify early stages of CKD, providing insights into the possible pathophysiologic processes that contribute to the development and progression of CKD.

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“…Apesar da possibilidade de outra via ser estimulada para gerar ATP, a doença renal crônica é uma enfermidade que resulta em diminuição da oxidação de ácidos GAYAR et al, 1994;SULIMAN et al, 2005) Já a ureia, molécula filtrada pelos glomérulos e parcialmente reabsorvida pelos túbulos proximais e distais, também é um dos biomarcadores mais afetados quando há redução na TFG (DOSSETOR, 1966;PARK;RABINOWITZ, 1969;BRAUN;LEFEBVRE, 2008;KOBAYASHI, 2015). Porém, é válido relembrar que esta é uma molécula sintetizada no fígado e que além disso pode ser influenciada pela desidratação, desnutrição, estado de catabolismo proteico, teor de proteína da dieta, utilização de glicocorticoide, além de sangramento gastrintestinal.…”

Section: Variávelunclassified

>b<Caracterização do metaboloma sérico de gatos com doença renal crônica>/b<

Ruberti¹

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Agradeço a Deus por me guiar em meus caminhos, por me dar força e trazer paz em todos os momentos. Aos meus pais Francisco e Fátima, que são a minha base, que sempre me apoiaram e me propuseram todas as melhores oportunidades na vida, nunca medindo esforços para comigo. À minha irmã Camila que está sempre ao meu lado, torcendo e vibrando junto comigo. Para sempre minha pequena. Eu amo vocês, obrigada por tudo. Ao Ruã, meu companheiro e maior incentivador, caminhando sempre ao meu lado e me impulsionando sempre a evoluir e conquistar todos os meus objetivos. Agradeço por todo carinho e ajuda em todos os momentos. Aos meus orientadores Profa. Dra. Marcia Mery Kogika e Prof. Dr. Marcio Antonio Brunetto, grandes inspirações e exemplos a serem seguidos. Obrigada por toda confiança e por abrirem as portas da Universidade de São Paulo e do Centro de Pesquisa em Nutrologia de Cães e Gatos (CEPENpet) com tamanha generosidade. Agradeço pelos ensinamentos, orientações e momentos compartilhados. Às Médicas Veterinárias do Serviço de Clínica Médica do HOVET/FMVZ-USP, Khadine Kanayama, Bruna Coelho e Denise Simões, aos enfermeiros Milton Gregório e Elias Gonçalves e aos residentes por toda amizade, auxílio e colaboração no atendimento aos animais.

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Alterations of plasma free amino acids in nephrotic syndrome

Cited by 6 publications

References 8 publications

Amino acid status in dogs with protein‐losing nephropathy

Amino acid status in dogs with protein‐losing nephropathy

Serum Metabolites Characterization Produced by Cats CKD Affected, at the 1 and 2 Stages, before and after Renal Diet

>b<Caracterização do metaboloma sérico de gatos com doença renal crônica>/b<

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