Alterations of Plasma Microbiome: A Potentially New Perspective to the Dysbiosis in Systemic Lupus Erythematosus?

Liu, Yudong; Xiao, Fei; Zhang, Rui; Zhang, Xuan

doi:10.3899/jrheum.220023

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Lupus is a systemic autoimmune disease, and we hypothesize that systemic microbial translocation of specific microbial types may play a more critical role in disease pathogenesis than measures of the microbiome from the surface barriers, such as the gut, skin, oral cavity, and genital areas. If our hypothesis is correct, analysis of SLE‐associated plasma microbiome alterations may provide novel insight into understanding systemic inflammation and disease pathogenesis in SLE 12 …”

Section: Introductionmentioning

confidence: 95%

“…If our hypothesis is correct, analysis of SLE-associated plasma microbiome alterations may provide novel insight into understanding systemic inflammation and disease pathogenesis in SLE. 12 Currently, there are limited reports of racial differences in plasma microbial translocation and the plasma microbiome in patients with SLE. A prior study reported blood levels of total microbial 16S DNA levels in the general population from 1,285 randomly recruited age-stratified individuals.…”

Section: Introductionmentioning

confidence: 99%

“…If our hypothesis is correct, analysis of SLE‐associated plasma microbiome alterations may provide novel insight into understanding systemic inflammation and disease pathogenesis in SLE. 12 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Racial Differences in Plasma Microbial Translocation and Plasma Microbiome, Implications in Systemic Lupus Erythematosus Disease Pathogenesis

Wen,

Ogunrinde,

Wan

et al. 2024

ACR Open Rheumatology

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ObjectiveBlack groups have increased prevalence and accelerated pathogenicity of systemic lupus erythematosus (SLE) compared to other ethnic/racial groups. The microbiome and systemic microbial translocation are considered contributing factors to SLE disease pathogenesis. However, racial differences in the plasma microbiome and microbial translocation in lupus remain unknown.MethodsIn the current study, we investigated plasma levels of microbial translocation (lipopolysaccharide [LPS] and zonulin) and the plasma microbiome using microbial 16S RNA sequencing of Black and White patients with SLE and Black and White healthy controls.ResultsPlasma microbial translocation was increased in Black patients versus in White patients and in patients with SLE versus healthy controls regardless of race. Compared to sex, age, and disease status, race had the strongest association with plasma microbiome differences. Black groups (Black controls and Black patients) had lower α‐diversity than White groups (White controls and White patients) and more distinct β‐diversity. Black and White patients demonstrated differences in plasma bacterial presence, including Staphylococcus and Burkholderia. Compared to White patients, Black patients had higher SLE Disease Activity Index (SLEDAI) scores and urinary protein levels as well as a trend for increased anti–double‐stranded DNA (dsDNA) antibody levels consistent with the known increased severity of lupus in Black patients overall. Certain plasma bacteria at the genus level were identified that were associated with the SLEDAI score, urinary protein, and anti‐dsDNA antibody levels.ConclusionThis study reveals racial differences in both quality and quantity of plasma microbial translocation and identified specific plasma microbiome differences associated with SLE disease pathogenesis. Thus, this study may provide new insights into future potential microbiome therapies on SLE pathogenesis.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%