Alterations of Power Spectral Density in Salience Network during Thought-action Fusion Induction Paradigm in Obsessive-compulsive Disorder

Abstract

Objective: Recent studies highlighted the triple-network model which illustrated the interactions among three large-scale networks including salience network (SN). The functional magnetic resonance imaging used in this study was designed to investigate the characteristics of three large-scale networks associated with the thought-action fusion (TAF) in patients with obsessive-compulsive disorder (OCD) using power spectral density (PSD) analysis. Methods: This study included 32 OCD patients and 38 age-matched healthy controls (HC). The TAF task was modified from the experiment of Rassin. PSD from time courses in large-scale networks of each subject was measured to compare between the groups for both TAF and resting state. Results: In SN, OCD reported lower power in the low-frequency domain of SN compared to HC using the two-sample t test during the TAF task (t = −2.395, p = 0.019) but not in the resting state. The PSD in the low-frequency domain of the SN had a significant negative correlation with state score in the guilty inventory (r = −0.361, p = 0.042) in OCD patients. Conclusion: This study suggests that OCD patients showed reduced SN power which can be prominent in a certain situation, such as TAF. In addition, the PSD alterations in SN cause difficulty in processing ambiguous emotional cues in social situations, and the difficulty can be connected with a negative feeling (e.g., guilt).

Convergent functional change of frontoparietal network in obsessive-compulsive disorder: a voxel-based meta-analysis

“…Based on ALE results, we found characteristic alterations in the FPN of OCD, as well as underlying brain regions that interact with other networks, such as the DMN, SN and fronto-striatal loop. The triple network model and classical fronto-striatal circuit may underlie the pathophysiology of OCD ( 83 , 84 ).Furthmore, the mate-analysis emphasizes the importance of the FPN in OCD pathology.…”

Altered Functional Connectivity of the Nucleus Accumbens and Amygdala in Cyber Addiction: A Resting State Functional Magnetic Resonance Imaging Study

“…The development of computers and the Internet has brought many conveniences to our society [ 1 - 3 ]. However, the excessive use of computers and the Internet, defined as cyber addiction, causes serious psychological, physical, and social problems.…”