2003
DOI: 10.1097/01.ccm.0000079608.00875.14
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Alterations of red blood cell shape and sialic acid membrane content in septic patients

Abstract: RBCs of septic patients are characterized by a more spherical shape, a decreased capacity of sphericity in hypo-osmolar solution, and a reduction in the sialic acid content of the RBC membrane. These modifications in RBC shape and membrane may contribute to the RBC rheologic abnormalities frequently described in sepsis.

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Cited by 108 publications
(114 citation statements)
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“…Numerous studies in both animal and human sepsis using a variety of techniques have documented decreases in RBC deformability (16,34). The decreased deformability in septic RBCs has been implicated in alteration of microvascular hemodynamics with a concomitant decrease in oxygen utilization and tissue ischemia (31). Multiple mechanisms for reduced RBC deformability in sepsis have been postulated, including membrane changes induced by lipid peroxidation, oxidative stress, hemoglobin cross-linking, decreased intracellular ATP, loss of membrane surface sialic acid, and NO (21,31,39).…”
mentioning
confidence: 99%
“…Numerous studies in both animal and human sepsis using a variety of techniques have documented decreases in RBC deformability (16,34). The decreased deformability in septic RBCs has been implicated in alteration of microvascular hemodynamics with a concomitant decrease in oxygen utilization and tissue ischemia (31). Multiple mechanisms for reduced RBC deformability in sepsis have been postulated, including membrane changes induced by lipid peroxidation, oxidative stress, hemoglobin cross-linking, decreased intracellular ATP, loss of membrane surface sialic acid, and NO (21,31,39).…”
mentioning
confidence: 99%
“…Alteración reológica de los hematíes, siendo más esféricos y con dificultad para modificar su forma, ocasionado por alteraciones en el contenido de acido siálico de la membrana eritrocitaria 30 .…”
Section: Alteraciones Microcirculatorias En La Sepsisunclassified
“…18 Vasodilation secondary to the inflammatory response may lead to an increased blood volume, which in turn may contribute to a decreased hematocrit in spite of a constant red cell mass. Increased red blood cell (RBC) uptake by the reticuloendothelial system due to alterations of the RBC membrane 19 could also contribute to the development of anemia in critically ill patients.…”
Section: Anemia In the Critically Illmentioning
confidence: 99%