Alterations of serum selenium concentrations in the acute phase of pathological conditions

Maehira, Fusako; Luyo, Gloria A.; Miyagi, Ikuko; Oshiro, Minoru; Yamane, Nobuhisa; Kuba, Mutsuo; Nakazato, Yukiyasu

doi:10.1016/s0009-8981(01)00744-6

Cited by 135 publications

(94 citation statements)

References 31 publications

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“…According to findings described for other diseases, the selenium decrease in liver and plasma during an acute-phase response is associated with an increase of CRP synthesis in liver (Maehira et al, 2002). A decrease in nail selenium concentrations in subjects with inflammatory diseases compared with healthy subjects has been reported earlier (Musil et al, 2005), highlighting the relation between inflammation and concentrations of antioxidants.…”

Section: Discussionmentioning

confidence: 66%

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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Objectives: To evaluate the associations between serum complement factor 3 (C3) and several anthropometrical, biochemical and lifestyle features in healthy young adults, emphasizing on the putative effect of selenium intake on C3 concentrations. Methods: This study enrolled 100 healthy young adults aged 18-34 years. Anthropometric and blood pressure measurements and lifestyle features were analyzed. Fasting blood samples were collected for the measurement of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol, triacylglycerols and C3 concentrations. Nail samples were collected for the analysis of selenium concentrations. Results: Values of BMI (P ¼ 0.034), sum of skinfold thicknesses (STs) (P ¼ 0.021), body fat mass (BFM) (P ¼ 0.023), percentage of overweight subjects (P ¼ 0.007), serum triacylglycerols (P ¼ 0.012) and nail selenium (P ¼ 0.001) were significantly different between subjects above and below the median of serum C3 concentrations. The following correlations with serum C3 were identified tricipital ST (P ¼ 0.033), sum of STs (P ¼ 0.012), BMI (P ¼ 0.008), BFM (P ¼ 0.018), waist-to-height ratio (P ¼ 0.016), serum glucose (P ¼ 0.045), serum triacylglycerols (P ¼ 0.001) and nail selenium (P ¼ 0.006). Circulating C3 showed a positive association with several adiposity markers such as BMI (P ¼ 0.001), waist circumference (P ¼ 0.006), waist-to-height ratio (P ¼ 0.002), BFM (P ¼ 0.025), as well as serum glucose (P ¼ 0.027) and triacylglycerols (Po0.001), whereas nail selenium was a statistically significant negative predictor of C3 concentrations (P ¼ 0.018). Conclusions: C3 seems to be related with selenium status and several anthropometrical and biochemical measurements linked to metabolic syndrome in apparently healthy young adults. These findings suggest a possible role for selenium intake in the modulation of C3, whose assessment may be an early marker of metabolic syndrome manifestations.

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Section: Discussionmentioning

confidence: 66%

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

et al. 2008

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“…Deficiencies in trace elements, Se, and zinc, and other nutrients may exacerbate CRISIS. In fact, several different inflammatory conditions in humans such as clinical sepsis have been associated with significantly decreased Se status (107,152). Injection of LPS in rats to induce an acute phase response results in significantly decreased Se in plasma and liver (152).…”

Section: B Critical Illness Stress-induced Immune Suppressionmentioning

confidence: 99%

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Huang

Rose

Hoffmann

2012

Antioxidants & Redox Signaling

710

496

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Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity. Adequate levels of Se are important for initiating immunity, but they are also involved in regulating excessive immune responses and chronic inflammation. Evidence has emerged regarding roles for individual selenoproteins in regulating inflammation and immunity, and this has provided important insight into mechanisms by which Se influences these processes. Se deficiency has long been recognized to negatively impact immune cells during activation, differentiation, and proliferation. This is related to increased oxidative stress, but additional functions such as protein folding and calcium flux may also be impaired in immune cells under Se deficient conditions. Supplementing diets with above-adequate levels of Se can also impinge on immune cell function, with some types of inflammation and immunity particularly affected and sexually dimorphic effects of Se levels in some cases. In this comprehensivearticle, the roles of Se and individual selenoproteins in regulating immune cell signaling and function are discussed. Particular emphasis is given to how Se and selenoproteins are linked to redox signaling, oxidative burst, calcium flux, and the subsequent effector functions of immune cells. Data obtained from cell culture and animal models are reviewed and compared with those involving human physiology and pathophysiology, including the effects of Se levels on inflammatory or immune-related diseases including anti-viral immunity, autoimmunity, sepsis, allergic asthma, and chronic inflammatory disorders. Finally, the benefits and potential adverse effects of intervention with Se supplementation for various inflammatory or immune disorders are discussed. Antioxid. Redox Signal. 16, 705-743.

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“…Plasma selenium levels are low in patients with severe illness and sepsis (15) leading to low GSH-Px activity and a redistribution of selenium occurs away from the liver to the muscles, at least in rats (8); therefore, a decreased production and activity of the selenium-dependent deiodinases has been supposed (11), leading to impaired T4 and T3 metabolism. It has already been shown that in critically ill patients, selenium substitution leads to an earlier normalization of plasma T3 levels compared with controls (16) and that low plasma selenium levels correlate with low T3 levels (17).…”

Section: Introductionmentioning

confidence: 99%

Selenium substitution has no direct effect on thyroid hormone metabolism in critically ill patients

Angstwurm

Schopohl

Gaertner

2004

European Journal of Endocrinology

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Background: In severe illness, plasma selenium levels are decreased; a decreased activity of the selenoenzyme 5 0 -deiodinase has been hypothesized to contribute to low tri-iodothyronine (T3) levels in non-thyroidal illness (NTI) syndrome in these patients. Objective: To analyse the influence of selenium substitution on thyroid hormone metabolism in patients with severe sepsis. Design: A prospective, randomized, controlled study at the medical internal intensive care unit of the University of Munich. Results are for 41 consecutive patients with severe sepsis with an APACHE II score . 15. Patients received either sodium selenite (500 mg/day for the first 3 days, reducing to 250 and then 125 mg/day every 3 days) or a placebo. Results: At study entry, APACHE II score and demographics were identical in both groups. The mean levels of TSH, free tri-iodithyronine and total T3, as well as plasma selenium and selenium-dependent peroxidase (GSH-Px) activity, were decreased. Plasma selenium and GSH-Px activity were normalized on days 3, 7 and 14 in patients receiving selenium (n ¼ 21), but remained below normal in the control patients. Patients receiving selenium had a better clinical outcome and thyroid hormone levels normalized earlier. Thyroid hormone levels increased in patients who showed clinical improvement, independent of selenium levels or selenium substitution. Conclusions: Selenium substitution in patients with NTI improves morbidity, but has no direct effect on the free and total thyroid hormones. In severely ill patients, decreased deiodinase activity due to low plasma selenium levels seems unlikely. After clinical revival, TSH and then the thyroidal hormones normalize independently of selenium substitution.

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Alterations of serum selenium concentrations in the acute phase of pathological conditions

Cited by 135 publications

References 31 publications

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

Selenium intake reduces serum C3, an early marker of metabolic syndrome manifestations, in healthy young adults

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

Selenium substitution has no direct effect on thyroid hormone metabolism in critically ill patients

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