Alterations of skeletal muscle in chronic heart failure.

Drexler, Helmut; Riede, U. N.; Münzel, Thomas; König, Hannah M.; Funke, E.; Just, Hanjörg

doi:10.1161/01.cir.85.5.1751

Cited by 692 publications

(499 citation statements)

References 53 publications

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“…Nevertheless, this long-term decline in exercise tolerance following the procedure may also be related to the disease progression (17) or to the reduced capacity to increase the cardiac output (Q) in response to exercise secondary to the Fontantype circulation, thus limiting the oxygen transport to the periphery (22,23). Slower oxygen uptake kinetics, ie, the precise integration of the cardiorespiratory system required to transport the oxygen from the atmosphere through active muscles to achieve oxidative phosphorylation (24), is well documented in patients with coronary artery disease, cyanotic congenital heart disease or heart failure (25)(26)(27)(28)(29)(30)(31). In patients who have had a Fontan procedure, slower oxygen uptake kinetics was observed compared with those of healthy individuals, suggesting alterations in the central component (oxygen transport) and/or in the peripheral component (oxygen utilization) during exercise (32).…”

Section: Clinical Studiesmentioning

confidence: 99%

Exercise capacity and impact of exercise training in patients after a Fontan procedure: A review

Brassard

Bédard

Jobin

et al. 2006

Canadian Journal of Cardiology

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Section: Clinical Studiesmentioning

confidence: 99%

Exercise capacity and impact of exercise training in patients after a Fontan procedure: A review

Brassard

Bédard

Jobin

et al. 2006

Canadian Journal of Cardiology

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“…For example, declines in immune function with age increase the risk of pulmonary viral and bacterial infections leading to pneumonia. Decreased physical activity will lead to deconditioning of cardiopulmonary function, general vascular tone, and the fitness of voluntary muscles that may impair the efficiency of peripheral vascular function (10,18,20,21). Thus, current reductions in the prevalence of chronic disability may affect the future prevalence of chronic disease and mortality risk in the United States elderly population.…”

mentioning

confidence: 99%

Chronic disability trends in elderly United States populations: 1982–1994

Mantón

Corder²,

Stallard³

1997

Proc. Natl. Acad. Sci. U.S.A.

579

301

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Statistically significant declines in chronic disability prevalence rates were observed in the elderly United States population between the 1982 and 1989 National Long Term Care Surveys (NLTCS). The 1994 NLTCS was used to investigate whether disability rate declines continued to 1994. The 1982The , 1984The , 1989, and 1994 NLTCS employ the same sample design and instrumentation so that trends in disability can be estimated with minimal sampling and measurement bias. Age (5-year categories from 65 to >95)-specific rates were calculated for the 1982 NLTCS and applied to United States Census Bureau estimates of the 1994 population to calculate chronic disability prevalence rates adjusted for aging in the United States population aged >65. The 1982 age standardized rates were compared with 1994 NLTCS estimates. The prevalence of disability estimated for 1994 (21.3%) was 3.6% lower than the 1982 age standardized rate (24.9%)-a highly significant reduction (t ‫؍‬ ؊8.5; P < < 0.0001). Of the 3.6 percentage point decline in prevalence, 1.7% occurred in the 5 years between 1989 and 1994-compared with the 1.9% decline in the 7 years between 1982 and 1989. Both declines are significant. Because of the shorter time period, the per year decline in disability prevalence from 1989 to 1994 was greater than that from 1982 to 1989. Given the higher acute and long-term care service needs of the disabled elderly population, Medicare, Medicaid, and private health expenditures may be dramatically lower than if declines had not occurred.

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“…Although the results for quality of life were not different between the groups, it can be observed that in the present study day-to-day activities, represented by the 6MWT, CT and ST, were impaired for patients with HF+PVI. We believe that histological abnormalities in skeletal muscle of HF patients, such as muscle atrophy and reduced mitochondrial density, [21][22][23] may have impacted these patients' capacity for microvascular O 2 extraction. This in turn suggests that the patients with mixed disease suffer greater musculoskeletal compromise, leading to lower tolerance of exercise, as observed in the clinical tests.…”

Section: Discussionmentioning

confidence: 99%

Peripheral vascular insufficiency impairs functional capacity in patients with heart failure

et al. 2014

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INTRODUCTION: Heart failure (HF) is a complex syndrome in which effort limitation is associated with deterioration of peripheral musculature. Improving survival rates among these patients have led to the appearance of cases in which other pathologies are associated with HF, such as peripheral vascular insufficiency (PVI). The combination of these two pathologies is common, with significant repercussions for affected patients. OBJECTIVE: To compare functional limitations and quality of life between patients with HF in isolation or HF + PVI. METHOD: Twelve patients with HF+PVI were paired to 12 patients with HF in isolation. All had ejection fraction <40%. The following were conducted: 6 minute walk test (6MWT), chair test (CT), step test (ST), one repetition maximum test (1RM) and quality of life questionnaire. RESULTS: The results for the 6MWT (311±27 vs. 447±29), ST (49±3 vs. 81±10) and CT (17±1 vs. 21±1) were lower in the HF+PVI group than in the HF group (p<0.05). The HF+PVI group exhibited a reduction in the number of steps taken from the first to the second minute of the ST, in relation to the HF group. The HF group exhibited better HR recovery than the HF+PVI group (50±4 vs. 26±3; p<0.05). No differences were found in results for the Borg scale, the peripheral muscle strength test (1RM) or the questionnaires (p>0.05). CONCLUSIONS: The study participants who had mixed disease exhibited a greater degree of functional impairment than the group with HF, without reporting worsened quality of life.

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Alterations of skeletal muscle in chronic heart failure.

Cited by 692 publications

References 53 publications

Exercise capacity and impact of exercise training in patients after a Fontan procedure: A review

Exercise capacity and impact of exercise training in patients after a Fontan procedure: A review

Chronic disability trends in elderly United States populations: 1982–1994

Peripheral vascular insufficiency impairs functional capacity in patients with heart failure

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