Alterations of the Brain Proteome and Gut Microbiota in <scp>d</scp>-Galactose-Induced Brain-Aging Mice with Krill Oil Supplementation

Jiang, Qinqin; Lu, Chenyang; Sun, Tingting; Zhou, Jun; Li, Ye; Ming, Tinghong; Bai, Linquan; Wang, Zaijie Jim; Su, Xiurong

doi:10.1021/acs.jafc.9b03827

Cited by 17 publications

(9 citation statements)

References 46 publications

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“…Hence, maintaining the normal oxidation-reduction balance of the organism is essential to the overall health of human beings. According to the reported antioxidant mechanism, living organisms remove excessive oxygen free radicals by scavenging ROS precursors, chelating with metal ions involved in the formation of ROS, and increasing endogenous antioxidant defenses in the body [ 4 ]. Given the important impact of oxidative stress on living organisms, adding various antioxidant supplements into the daily diet is essential to antagonize oxidative stress and maintain normal body organs.…”

Section: Introductionmentioning

confidence: 99%

“…d -gal can be converted to galactitol after prolonged injection of high-dose. Because galactitol cannot be decomposed, and accumulates in the cells, leading to enhanced ROS eventually [ 4 , 9 , 10 ]. The present study evaluated the antioxidant capacity of PPF in vivo, investigated the underlying mechanism, and explored the correlation between the gut microbiota and antioxidant status in the d -gal-induced oxidative stress mouse model.…”

Section: Introductionmentioning

confidence: 99%

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Flavonoid-Rich Extract of Paeonia lactiflora Petals Alleviate d-Galactose-Induced Oxidative Stress and Restore Gut Microbiota in ICR Mice

2021

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This study was aimed to investigate the antioxidant effect of Paeonia lactiflora Pall. petal flavonoids extract (PPF) on d-galactose (d-gal)-induced ICR mice. In this study, sixty male ICR mice were randomly divided into six groups during an 8 weeks experimental period, including normal control (NC) group, d-gal group, epigallocatechin gallate (EGCG) group, low, medium, and high dose PPF groups (10, 20 and 40 mg/kg/day). The results showed that intragastric administration with PPF significantly reverses the atrophy of the visceral organs of oxidative damage mice in a dose-dependent relationship. PPF indicated the antioxidant capacity to decrease the malondialdehyde (MDA) level and improve the activity of superoxide dismutase (SOD), catalase (CAT) as well as glutathione peroxidase (GSH-Px). In addition, PPF treatment reversed gut microbiota dysbiosis by increasing the relative abundance of Lactobacillaceae. Spearman correlation analysis showed that the body’s oxidative stress markers were directly related to changes in gut microbiota. These findings reveal firstly that PPF could alleviate d-Gal-induced oxidative stress and modulate gut microbiota balance.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Flavonoid-Rich Extract of Paeonia lactiflora Petals Alleviate d-Galactose-Induced Oxidative Stress and Restore Gut Microbiota in ICR Mice

2021

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“…Generally, diets were considered to play important roles in brain aging through the modulation of gene and protein expression [5]. Recent researchers suggested that dietinduced changes of gut microbiota also affected age-related pathogenesis [6]. Serine is a nutritionally nonessential amino acid, but it is a major substrate for the synthesis of glutathione.…”

Section: Introductionmentioning

confidence: 99%

Serine Deficiency Exacerbates Inflammation and Oxidative Stress via Microbiota-Gut-Brain Axis in D-Galactose-Induced Aging Mice

Wang

Zhou²,

Deng

et al. 2020

Mediators of Inflammation

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Inflammation and oxidative stress play key roles in the process of aging and age-related diseases. Since serine availability plays important roles in the support of antioxidant and anti-inflammatory defense system, we explored whether serine deficiency affects inflammatory and oxidative status in D-galactose-induced aging mice. Male mice were randomly assigned into four groups: mice fed a basal diet, mice fed a serine-and glycine-deficient (SGD) diet, mice injected with D-galactose and fed a basal diet, and mice injected with D-galactose and fed an SGD diet. The results showed that D-galactose resulted in oxidative and inflammatory responses, while serine deficiency alone showed no such effects. However, serine deficiency significantly exacerbated oxidative stress and inflammation in D-galactose-treated mice. The composition of fecal microbiota was affected by Dgalactose injection, which was characterized by decreased microbiota diversity and downregulated ratio of Firmicutes/Bacteroidetes, as well as decreased proportion of Clostridium XIVa. Furthermore, serine deficiency exacerbated these changes. Additionally, serine deficiency in combination with D-galactose injection significantly decreased fecal butyric acid content and gene expression of short-chain fatty acid transporters (Slc16a3 and Slc16a7) and receptor (Gpr109a) in the brain. Finally, serine deficiency exacerbated the decrease of expression of phosphorylated AMPK and the increase of expression of phosphorylated NFκB p65, which were caused by D-galactose injection. In conclusion, our results suggested that serine deficiency exacerbated inflammation and oxidative stress in D-galactose-induced aging mice. The involved mechanisms might be partially attributed to the changes in the microbiotagut-brain axis affected by serine deficiency.

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“…According to an experimental model, mice fed for 12 weeks with a high fat and high sugar diet showed obesity and hyperlipidemia. Treatment with a high dose (600 µg/g/day) of krill oil, but not with lower doses (100 µg/g/day or 200 µg/g/day) improved the microbiotic alteration and cardiometabolic parameters [126].…”

Section: Krill and Inflammatory Bowel Diseases And Gut Microbiotamentioning

confidence: 91%

Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications

et al. 2021

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Euphausia superba, commonly known as krill, is a small marine crustacean from the Antarctic Ocean that plays an important role in the marine ecosystem, serving as feed for most fish. It is a known source of highly bioavailable omega-3 polyunsaturated fatty acids (eicosapentaenoic acid and docosahexaenoic acid). In preclinical studies, krill oil showed metabolic, anti-inflammatory, neuroprotective and chemo preventive effects, while in clinical trials it showed significant metabolic, vascular and ergogenic actions. Solvent extraction is the most conventional method to obtain krill oil. However, different solvents must be used to extract all lipids from krill because of the diversity of the polarities of the lipid compounds in the biomass. This review aims to provide an overview of the chemical composition, bioavailability and bioaccessibility of krill oil, as well as the mechanisms of action, classic and non-conventional extraction techniques, health benefits and current applications of this marine crustacean.

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Alterations of the Brain Proteome and Gut Microbiota in d-Galactose-Induced Brain-Aging Mice with Krill Oil Supplementation

Cited by 17 publications

References 46 publications

Flavonoid-Rich Extract of Paeonia lactiflora Petals Alleviate d-Galactose-Induced Oxidative Stress and Restore Gut Microbiota in ICR Mice

Flavonoid-Rich Extract of Paeonia lactiflora Petals Alleviate d-Galactose-Induced Oxidative Stress and Restore Gut Microbiota in ICR Mice

Serine Deficiency Exacerbates Inflammation and Oxidative Stress via Microbiota-Gut-Brain Axis in D-Galactose-Induced Aging Mice

Advances in Technologies for Highly Active Omega-3 Fatty Acids from Krill Oil: Clinical Applications

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