Alterations of the Corpuscular Elements of Human and Canine Blood in Bubble and Disc Oxygenators

Prolonged veno-arterial partial extracorporeal circulation using membrane oxygenator was performed in 19 alert dogs. Investigations of alterations in the corpuscular elements of the blood during the perfusion showed 89 mg% as the highest value of free haemoglobin. A significant decrease in the platelet count during the first two hours of bypass to a value of about 100 000/mm3 was found. Measurements of lung and heart functions did not reveal any significant differences between the baseline values and those obtained after 24 hours' bypass and again after three months' observation. Microscopic examination of the lungs and hearts only showed moderate focal alveolar oedema in the dogs killed immediately after 24 hours' bypass. These alterations could be explained as a consequence of the extracorporeal circulation. No changes were found at the microscopic examination of the lungs and hearts three months later. By haemodilution technique, the dogs suffered from severe universal oedema after a few hours of bypass and the perfusion time in these experiments did not exceed 13 hours. The observation that 24 hours of partial veno-arterial bypass using membrane oxygenators in healthy dogs causes only minor changes in heart and lung function and in lung histology might explain the possibility of using such oxygenators in prolonged perfusions.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Alterations of the Corpuscular Elements of Human and Canine Blood in Bubble and Disc Oxygenators

Cited by 2 publications

References 18 publications

The influence of cardiopulmonary bypass on the size of human platelets

The influence of cardiopulmonary bypass on the size of human platelets

Cardiopulmonary Function During and After Prolonged Extracorporeal Circulation with Membrane Oxygenators in Dogs

Contact Info

Product

Resources

About