1979
DOI: 10.1016/s0014-4908(79)80041-1
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Alterations of the nucleus ruber in 3-acetylpyridine intoxication

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Cited by 2 publications
(3 citation statements)
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“…It is incorporated into pyridine nuleotides and, owing to the lack of specificity of the NAD(P) nucleosidase [NAD(P) glycohydrolase], 3-AP-containing abnormal NAD(P) analogues are formed which interferes with intracellular electron transport (Szalay et aL, 1979). The impairment of the intracellular electron transport may lead to the disturbance of ATP synthesis resulting in catecholamine depletions due to the intracellular impairment of granule resynthesis.…”
Section: Discussionmentioning
confidence: 99%
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“…It is incorporated into pyridine nuleotides and, owing to the lack of specificity of the NAD(P) nucleosidase [NAD(P) glycohydrolase], 3-AP-containing abnormal NAD(P) analogues are formed which interferes with intracellular electron transport (Szalay et aL, 1979). The impairment of the intracellular electron transport may lead to the disturbance of ATP synthesis resulting in catecholamine depletions due to the intracellular impairment of granule resynthesis.…”
Section: Discussionmentioning
confidence: 99%
“…In this case, the doses introduced into the mouse were relatively low (200 mg/kg). However, 3-AP given in one single dose near the LDs0 causes cellular necrosis in brain regions such as the red nucleus (Szalay et al, 1979), inferior olivary complex, stratum pyramidale hippocampi, and nucleus supraopticus of the rat and mouse, as well as the spinal and sympathetic ganglia and adrenal medulla (Hicks, 1955).…”
Section: Introductionmentioning
confidence: 99%
“…15, 211. However, 3-AP produces lesions in other brain regions which do not exhibit metabolic rates as great as the hippocampus [26], leaving unexplained the basis for the selective nature of 3-AP neurotoxicity.…”
Section: Nadp-dependent Metabolic Pathways After Incorporationmentioning
confidence: 99%