Alterations of white matter connectivity in first episode schizophrenia

Federspiel, Andrea; Begré, Stefan; Kiefer, Claus; Schroth, Gerhard; Strik, Werner; Dierks, Thomas

doi:10.1016/j.nbd.2006.01.015

Cited by 106 publications

(101 citation statements)

References 52 publications

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“…In both first-episode and chronic patients, alterations were found in motor tracts such as the internal capsule or the corpus callosum [142,206,207,208,209], but also in the premotor and motor cortex [210]. Interestingly, in early-onset schizophrenia, white matter maturation is delayed, especially in bilateral frontal lobes and the pyramidal tract [207,211].…”

Section: Neurobiology Of the Motor System In Schizophreniamentioning

confidence: 99%

Motor Symptoms and Schizophrenia

Walther¹,

Strik²

2012

Neuropsychobiology

306

233

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Classical schizophrenia literature reports motor symptoms as characteristic of the disorder. After the introduction of neuroleptic drugs, the existence of genuine motor disorders was challenged. Renewed interest arose as symptoms were found in never-medicated patients. Reports focused on abnormal involuntary movements, parkinsonism, neurological soft signs, catatonia, negative symptoms, or psychomotor slowing. Since these syndromes refer to different concepts, however, the definitions are not congruent and the symptoms overlap. The prevalence rates of motor symptoms in schizophrenia are surprisingly high, and recent studies indicate a possible pathobiology. In particular, the development and maturation of the human motor system appears to be closely linked to the emergence of motor symptoms observed in schizophrenia. Post-mortem and neuroimaging results demonstrated aberrant structure and function of premotor and motor cortices, basal ganglia, thalamus, and the connecting white matter tracts. Animal models have focused on aberrant neurotransmission and genetic contributions. Findings of localized abnormal oligodendrocyte function and myelination point to the special role of the white matter in schizophrenia, and recent studies specifically found an association between motor abnormalities and white matter structure in schizophrenia. This review of the literature supports the idea that motor symptoms are closely related to the neurodevelopmental disturbances of schizophrenia and a distinct syndromal dimension with its own pathophysiology.

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Section: Neurobiology Of the Motor System In Schizophreniamentioning

confidence: 99%

Motor Symptoms and Schizophrenia

Walther¹,

Strik²

2012

Neuropsychobiology

306

233

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“…Another DTI study of 12 first-episode patients with schizophrenia found an increased intervoxel coherence, which corresponds to high FA, in the thalamic radiations. 23 The pathophysiologic correlates of decreased MD and increased FA in patients with schizophrenia can be diverse. First, an increased WM fiber attenuation in patients with schizophrenia vs healthy participants is observed, as shown by postmortem studies investigating the WM architecture of patients with schizophrenia.…”

Section: Wm Findingsmentioning

confidence: 99%

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Filippi

Canu

Gasparotti

et al. 2013

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Previous studies have suggested that structural changes do occur in the brain of patients with schizophrenia compared with healthy control participants. However, findings from such studies are inconclusive, probably because of the different methodologic approaches, the clinical heterogeneity of patient samples, and also the fact that patients enrolled were treated with antipsychotic drugs. The aim of this study was to investigate brain GM volumes and intrinsic structural WM changes in first-contact, antipsychotic drug-naïve patients with schizophrenia.

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“…In schizophrenia, two regions with decreased structural integrity are consistently reported: the anterior part of the corpus callosum and an area in the left temporal lobe white matter (Camchong et al, 2009;EllisonWright and Bullmore, 2009), indicating a disconnection of gray matter areas. Additionally, in schizophrenic patients a dysregulation of the WMN and the DMN was observed during a working memory task (Federspiel et al, 2006). Taken together, the fasciles connecting the regions within the DMN and the WMN show decreased integrity in disease and the networks themselves display a reduced functionality, which may explain the cognitive impairment.…”

mentioning

confidence: 92%

Linking Brain Connectivity Across Different Time Scales with Electroencephalogram, Functional Magnetic Resonance Imaging, and Diffusion Tensor Imaging

et al. 2012

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Structural and functional connectivity are intrinsic properties of the human brain and represent the amount of cognitive capacities of individual subjects. These connections are modulated due to development, learning, and disease. Momentary adaptations in functional connectivity alter the structural connections, which in turn affect the functional connectivity. Thus, structural and functional connectivity interact on a broad timescale. In this study, we aimed to explore distinct measures of connectivity assessed by functional magnetic resonance imaging and diffusion tensor imaging and their association to the dominant electroencephalogram oscillatory property at rest: the individual alpha frequency (IAF). We found that in 21 healthy young subjects, small intraindividual temporal IAF fluctuations were correlated to increased blood oxygenation level-dependent signal in brain areas associated to working memory functions and to the modulation of attention. These areas colocalized with functionally connected networks supporting the respective functions. Furthermore, subjects with higher IAF show increased fractional anisotropy values in fascicles connecting the above-mentioned areas and networks. Hence, due to a multimodal approach a consistent functionally and structurally connected network related to IAF was observed.

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Alterations of white matter connectivity in first episode schizophrenia

Cited by 106 publications

References 52 publications

Motor Symptoms and Schizophrenia

Motor Symptoms and Schizophrenia

Patterns of Brain Structural Changes in First-Contact, Antipsychotic Drug-Naïve Patients with Schizophrenia

Linking Brain Connectivity Across Different Time Scales with Electroencephalogram, Functional Magnetic Resonance Imaging, and Diffusion Tensor Imaging

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