Alterations of White Matter Integrity in Patients with Chronic Obstructive Pulmonary Disease: Tract-Based Analysis Using TRActs Constrained by UnderLying Anatomy

Um, Mi-Kyung; Lee, Seung Hwan; Kim, Woo Jin; Cho, Seong Whi; Yoon, Hye-Kyung; Lim, Myoung-Nam; Pyun, Sung Bom; Tae, Woo Suk; Kim, Sam-Soo

doi:10.3348/jksr.2017.77.3.148

Cited by 2 publications

(8 citation statements)

References 31 publications

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“…Chronic obstructive pulmonary disease (COPD) increases the risk of neuronal damage and cognitive dysfunction that increases the mortality and morbidity of the disease [11]. Neuronal damage could be due to chronic hypoperfusion, chronic systemic inflammation, which is observed with repeated acute exacerbations, or associated comorbidities as vascular disease and smoking [1,12,20].…”

Section: Discussionmentioning

confidence: 99%

“…Many studies performed on structural brain damage in COPD patients found a decrease in FA and increase in MD metrics throughout brain regions, mainly in cingulate gyrus, uncinate fasciculus and superior longitudinal fasciculus, which play a major role in cognitive performance [11,21,22]. Patients have been found to have abnormalities in cognition and daily activities [27][28][29]; this signifies that impaired brain microstructure and function related to cognition are recognized complications of COPD.…”

Section: Discussionmentioning

confidence: 99%

“…Diffusion tensor imaging (DTI) is an intrinsically T2weighted method that provides an evaluation of brain tissue microstructure and architecture in vivo through studying diffusion properties of water molecules within tissues. Moreover, it provides non-invasive quantitative parameters as fractional anisotropy (FA) which captures the directionality of diffusion inside the tissue and mean diffusivity (MD) which reflects the tissue microstructure, correlated with subtle tissue damage that is not detectable in T2 and fluid attenuation inversion recovery (FLAIR) imaging [7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

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Diffusion tensor imaging of white matter integrity in relation to smoking index and exacerbations in severe chronic obstructive pulmonary disease

Helmy¹,

Sakrana²,

Abdel-Fattah³

et al. 2019

Egypt J Radiol Nucl Med

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Background: Diffusion tensor imaging (DTI) is a non-invasive MR modality that provides an evaluation of brain tissue microstructure and architecture in vivo. We aimed to assess the diagnostic value of DTI parameters in evaluating cerebral white matter integrity in patients of severe chronic obstructive pulmonary disease (COPD) and correlate these parameters with smoking index (SI) and the number of exacerbations in the last year. This prospective study included 30 COPD male past smoker patients and 15 age-and sex-matched nonsmoker controls. Staging of COPD, SI and number of exacerbations in the last year were obtained. Routine brain MRI and DTI were done in all subjects. The selected white matter tracts' fractional anisotropy (FA), and mean diffusivity (MD) were calculated in the region of interest in axial slices. Results: The mean FA and MD values of all selected white matter tracts showed a high significant difference (p < 0.001) between patients and control group. The correlation between FA, SI and exacerbation frequency was not significant in the majority of white matter tracts (p > 0.05). The correlation between MD, SI and exacerbation frequency was significant for the majority of tracts (p < 0.05). Conclusion: DTI metrics are valuable non-invasive tools in evaluating the white matter abnormalities in COPD patients. Smoking index and frequency of exacerbations have possible relation to extra-pulmonary cerebral manifestations of COPD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diffusion tensor imaging of white matter integrity in relation to smoking index and exacerbations in severe chronic obstructive pulmonary disease

Helmy¹,

Sakrana²,

Abdel-Fattah³

et al. 2019

Egypt J Radiol Nucl Med

View full text Add to dashboard Cite

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“…The slice thickness was 4 mm, the matrix was 256 × 256, and the field of view was 220–240 mm. Axial 3D DTI was achieved using a single‐shot spin‐echo echo‐planar imaging (TR/TE = 7400/60 ms, 56 slices, acquisition matrix of 112 × 112 with pixel size of 2 × 2 × 2 mm 3 , interpolated to 1 × 1 × 2 mm 3 , 60 diffusion gradient directions with b = 1000 s/mm 2 , and three repeats of b = 0) 16 . Post‐processing was performed using MRI workstation software (ADW 4.7 Vantage, GE Medical Systems) by GE Software devised for tractography.…”

Section: Methodsmentioning

confidence: 99%

“…The analysis was based on the evaluation of DTI parameters; fractional anisotropy (FA), mean diffusivity (MD), and relative apparent diffusion coefficient values were assessed by placing small regions of interest (ROIs) measuring 2 × 2 mm 3 in different white matter areas in both cerebral hemispheres. All values were normalized to the values from the white matter of controlled volunteers to obtain relative values of all parameters 16,17 …”

Section: Methodsmentioning

confidence: 99%

Assessment of incidence of cerebral vascular diseases and prediction of stroke risk in chronic obstructive pulmonary disease patients using multimodal biomarkers

Badr

Elkholy

Shoeib

et al. 2023

Clinical Respiratory J

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Background Early assessment of cerebrovascular disease in chronic obstructive pulmonary disease (COPD) patients is an important issue for a favorable influence on the quality of life. Methodology This cross‐sectional case–control study was conducted on 38 eligible COPD patients (mean age 55.5 ± 11.5, 25 males, and 13 females) and 26 age‐/sex‐matched healthy controls. All participants were subjected to stroke risk screening instruments that included the Stroke Riskometer™, the Framingham 10‐Year Risk Score, the stroke risk screening tool (the Department of Disease Control of Thailand), the My Risk Stroke Calculator, and Q Stroke. Radiologically, diffusion tensor imaging (DTI) and echo‐gradient MRI (T2 star) T2 star imaging were done. Color‐coded duplex sonography was done. Laboratory investigations included C‐reactive protein (CRP), serum amyloid A, plasma fibrinogen level, serum IL6, 8‐Isoprostane, vWF and urinary albumin creatinine ratio. Results Stroke risk screening instruments revealed a significant increase in COPD patients. DTI showed a significant bilateral reduction in fractional isotropy and a significant bilateral increase in mean diffusivity of white matter through many areas in COPD patients. Patients also had a significant increase of intima–media thickness, presence of atherosclerotic focal thicknesses or plaques on duplex sonography. There was a significant elevation of CRP, serum amyloid A, plasma fibrinogen level, serum IL6, 8‐isoprostane, von Willebrand factor (vWF), and urinary albumin creatinine ratio in COPD patients. Conclusion COPD patients had an increased risk for stroke that could be assessed on stroke risk screening instruments, DTI, T2 star, duplex sonography, and laboratory investigation and could be correlated with the severity of the disease.

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Alterations of White Matter Integrity in Patients with Chronic Obstructive Pulmonary Disease: Tract-Based Analysis Using TRActs Constrained by UnderLying Anatomy

Cited by 2 publications

References 31 publications

Diffusion tensor imaging of white matter integrity in relation to smoking index and exacerbations in severe chronic obstructive pulmonary disease

Diffusion tensor imaging of white matter integrity in relation to smoking index and exacerbations in severe chronic obstructive pulmonary disease

Assessment of incidence of cerebral vascular diseases and prediction of stroke risk in chronic obstructive pulmonary disease patients using multimodal biomarkers

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