2008
DOI: 10.1111/j.1471-4159.2008.05506.x
|View full text |Cite
|
Sign up to set email alerts
|

Altered aminergic neurotransmission in the brain of organic cation transporter 3‐deficient mice

Abstract: Organic cation transporters (OCTs) are carrier-type polyspecific permeases known to participate in low-affinity extraneuronal catecholamine uptake in peripheral tissues. OCT3 is the OCT subtype most represented in the brain, yet its implication in central aminergic neurotransmission in vivo had not been directly demonstrated. In a detailed immunohistochemistry study, we show that OCT3 is expressed in aminergic pathways in the mouse brain, particularly in dopaminergic neurons of the substantia nigra compacta, n… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

14
101
0

Year Published

2009
2009
2022
2022

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 105 publications
(115 citation statements)
references
References 35 publications
14
101
0
Order By: Relevance
“…The present study demonstrates that while Oct3 is ubiquitously expressed in the brain (14,21,22), its cellular partition between astrocytes and neurons and among neuronal subpopulations is region specific. In particular, Oct3 immunoreactivity was detected in the nigrostriatal astrocytes, but not in astrocytes from regions such as cerebellum, hippocampus, and cortex.…”
Section: Discussionmentioning
confidence: 62%
“…The present study demonstrates that while Oct3 is ubiquitously expressed in the brain (14,21,22), its cellular partition between astrocytes and neurons and among neuronal subpopulations is region specific. In particular, Oct3 immunoreactivity was detected in the nigrostriatal astrocytes, but not in astrocytes from regions such as cerebellum, hippocampus, and cortex.…”
Section: Discussionmentioning
confidence: 62%
“…Oct3 knockout mice were generated as previously described in C57BL/6J background (Vialou et al, 2008), and wild-type mice were obtained from Jackson Laboratories (Bar Harbor, ME). Animal studies described here were conducted in male Oct3 knockout and wild-type mice (12-16 weeks old) and were reviewed and approved by University of California San Francisco Institutional Animal Care and Use Committee.…”
Section: Methodsmentioning
confidence: 99%
“…12) However, in the late 1990 s, a series of molecular cloning and functional expression analysis of transporters strongly suggested that organic cation transporter 3 (OCT3, SLC22A3) is likely to be a molecular entity of the EMT. [13][14][15] In situ hybridization and immunohistochemical analyses using rat or mouse brain have demonstrated that, in addition to its neuronal expression in the cerebellum, subfornical organ, dorsal raphe, hippocampus, and other brain regions, 13,[16][17][18][19] OCT3 is also expressed in astrocytes in several brain regions, such as the substantia nigra, striatum, hippocampus, and hypothalamic nuclei. 17,19) Astrocytic OCT3 expression has also been reported in human brain sections 19,20) and in primary human astrocytes.…”
Section: Organic Cation Transporter 3 (Oct3)mentioning
confidence: 99%
“…[13][14][15] In situ hybridization and immunohistochemical analyses using rat or mouse brain have demonstrated that, in addition to its neuronal expression in the cerebellum, subfornical organ, dorsal raphe, hippocampus, and other brain regions, 13,[16][17][18][19] OCT3 is also expressed in astrocytes in several brain regions, such as the substantia nigra, striatum, hippocampus, and hypothalamic nuclei. 17,19) Astrocytic OCT3 expression has also been reported in human brain sections 19,20) and in primary human astrocytes. [20][21][22] However, the absence of OCT3 expression in astrocytes has also been observed in some brain areas (such as the cerebellum), and primary human astrocytes are not always positive for OCT3 expression.…”
Section: Organic Cation Transporter 3 (Oct3)mentioning
confidence: 99%
See 1 more Smart Citation