Altered Amplitude of Low-Frequency Fluctuations in Early and Late Mild Cognitive Impairment and Alzheimer's Disease

Liang, P; Xiang, J; Liang, Huazheng; Qi, Z; Zhong, N; Li, Kangchen; Initiative, Bentham Science Publisher Alzheimer’s Disease NeuroImaging

doi:10.2174/1567205011666140425113143

Cited by 56 publications

(13 citation statements)

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“…All these functions of the region are important for judgments of self‐conscious emotions such as pride. Previous studies have shown decreased spontaneous activity in the PCC in mild cognitive impairment and Alzheimer's patients (Han et al, ; Liang et al, ). Therefore, low fALFF in the region among individuals with high hubristic pride might be associated with abnormal self‐referential processing.…”

Section: Discussionmentioning

confidence: 90%

Amplitude of Low‐Frequency Fluctuations During Resting State Differentially Predicts Authentic and Hubristic Pride

Kong

Liu

et al. 2017

Journal of Personality

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Section: Discussionmentioning

confidence: 90%

Amplitude of Low‐Frequency Fluctuations During Resting State Differentially Predicts Authentic and Hubristic Pride

Kong

Liu

et al. 2017

Journal of Personality

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“…The PCC is considered the central node in the DMN, and the decreased ALFF of this area is tightly linked to AD progression in previous studies. [42][43][44] The hypometabolism and atrophy of medial temporal lobe in AD progression was also revealed. 45,46 In this study, significantly decreased fALFF values in the left PCC and right MTG were observed in POAG patients, and those in the right MFG and left IPL were significantly increased in POAG patients.…”

Section: Discussionmentioning

confidence: 94%

Altered Amplitude of Low-Frequency Fluctuation in Primary Open-Angle Glaucoma: A Resting-State fMRI Study

Liu

et al. 2014

Investigative Ophthalmology & Visual Science

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Primary open-angle glaucoma is a neurodegenerative disease involving multiple brain regions, including the visual cortices, DMN, limbic system, and motor and sensory networks. Moreover, the alterations in some of these networks are correlated with the progression of POAG; for the abnormal spontaneous neural activities in the left cuneus, bilateral MTG and right prefrontal cortex are correlated with glaucoma severity.

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“…In this region, we tagged variants associated with dementia and decline in mental ability, including Alzheimer's disease [57][58][59] , frontotemporal dementia 60 , cerebral amyloid angiopathy 61 , cognitive decline 62 , cognitive impairment test score 63 , as well as many biomarkers of Alzheimer's disease, such as neurofibrillary tangles 61 , neuritic plaque 61 , cerebral amyloid deposition 64 , cerebrospinal fluid protein levels 63 , and cortical amyloid beta load 65 . Altered amplitude activity has been widely reported in patients of cognitive impairment and Alzheimer's disease 66,67 . The brain degeneration related to Alzheimer's disease may begin in the frontoparietal regions 68 and was associated with dysfunction of multiple RSNs, especially the default mode network 20 .…”

Section: The Shared Genetic Loci With Brain-related Complex Traits Anmentioning

confidence: 99%

Common variants contribute to intrinsic human brain functional networks

Zhao

Smith

et al. 2020

Preprint

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Human brain has a complex functional architecture and remains active during resting conditions. Resting-state functional magnetic resonance imaging (rsfMRI) measures brain activity at rest, which is closely linked with cognition and clinical outcomes. The role of genetics in human brain function is largely unknown. Here we utilized rsfMRI of 44,190 multi-ethnic individuals (37,339 in the UK Biobank) to discover the common genetic variants influencing intrinsic brain activity. We identified and validated hundreds of novel genetic loci associated with intrinsic functional signatures (P < 2.8 * 10^{-11}), especially for interactions of the central executive, default mode, and salience networks involved in the triple network model of psychopathology. A number of intrinsic brain activity associated loci had been implicated with brain disorders (e.g., Alzheimer's disease, Parkinson's disease, schizophrenia) and cognition, such as 17q21.31, 19q13.32, and 2p16.1. Genetic correlation analysis suggested the shared genetic influences among intrinsic brain function, brain structure, and brain structural connectivity. We also detected significant genetic correlations with 26 other complex traits, such as education, cognitive performance, ADHD, major depressive disorder, schizophrenia, sleep, and neuroticism. Heritability of intrinsic brain activity was enriched in brain tissues. The reported risk genes of Alzheimer's disease typically had stronger associations with intrinsic brain activity than brain structure, and the associated genes of intrinsic brain activity were enriched in multiple biological pathways related to nervous system and neuropathology (P < 1.8 * 10^{-9}).

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Altered Amplitude of Low-Frequency Fluctuations in Early and Late Mild Cognitive Impairment and Alzheimer's Disease

Cited by 56 publications

References 0 publications

Amplitude of Low‐Frequency Fluctuations During Resting State Differentially Predicts Authentic and Hubristic Pride

Amplitude of Low‐Frequency Fluctuations During Resting State Differentially Predicts Authentic and Hubristic Pride

Altered Amplitude of Low-Frequency Fluctuation in Primary Open-Angle Glaucoma: A Resting-State fMRI Study

Common variants contribute to intrinsic human brain functional networks

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