Altered auditory processing in acutely psychotic never-medicated first-episode patients

Valkonen‐Korhonen, Minna; Purhonen, Maija; Tarkka, Ina M.; Sipilä, Perttu; Partanen, Juhani; Karhu, Jari; Lehtonen, Johannes

doi:10.1016/s0926-6410(03)00199-x

Cited by 63 publications

(52 citation statements)

References 84 publications

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“…This fact, suggests that in the last decades N1 and N2 components have been studied as possible endophenotypes or bio-markers for different disorders and in some cases for recovery index: namely, in schizophrenia (Hegerl et al 1988;Haig et al 1997;Potts et al 1998a;Shelley et al 1999;Ford et al 2001;Brown et al 2002;Gilmore et al 2005;Neuhaus et al 2013), dementia (Verma et al 1989), Alzheimer (Sumi et al 2000), epilepsy and AED effects (Akaho 1996;Ford et al 2001;Lucchesi et al 2003), alcohol (Brigham et al 1997;Cohen et al 2002) and substance abuse (Tarter et al 1995;Brigham et al 1997), psychosis (Valkonen-Korhonen et al 2003), panic disorder (Wise et al 2009), Parkinson's disease (Wright et al (1996), ADHD (Johnstone et al 2001;Tsai et al 2012), stroke (Hirata et al 1996) and vascular cognitive impairment (van Harten et al 2006), myotonic dystrophy (Kazis et al 1996;Tanaka et al 2012), head injury (Reinvang et al 2000;Segalowitz et al 2001), (Guney et al 2009), amyotrophic lateral sclerosis (Ogawa et al 2009) and multiple sclerosis (Whelan et al 2010), more recently fragile X syndrome treatment (Schneider et al 2013), and bipolar disorder (Hamm et al 2013). …”

Section: Discussionmentioning

confidence: 99%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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Auditory event-related potentials (AERPs) are widely used in diverse fields of today's neuroscience, concerning auditory processing, speech perception, language acquisition, neurodevelopment, attention and cognition in normal aging, gender, developmental, neurologic and psychiatric disorders. However, its transposition to clinical practice has remained minimal. Mainly due to scarce literature on normative data across age, wide spectrum of results, variety of auditory stimuli used and to different neuropsychological meanings of AERPs components between authors. One of the most prominent AERP components studied in last decades was N1, which reflects auditory detection and discrimination. Subsequently, N2 indicates attention allocation and phonological analysis. The simultaneous analysis of N1 and N2 elicited by feasible novelty experimental paradigms, such as auditory oddball, seems an objective method to assess central auditory processing. The aim of this systematic review was to bring forward normative values for auditory oddball N1 and N2 components across age. EBSCO, PubMed, Web of Knowledge and Google Scholar were systematically searched for studies that elicited N1 and/or N2 by auditory oddball paradigm. A total of 2,764 papers were initially identified in the database, of which 19 resulted from hand search and additional references, between 1988 and 2013, last 25 years. A final total of 68 studies met the eligibility criteria with a total of 2,406 participants from control groups for N1 (age range 6.6-85 years; mean 34.42) and 1,507 for N2 (age range 9-85 years; mean 36.13). Polynomial regression analysis revealed that N1 latency decreases with aging at Fz and Cz, N1 amplitude at Cz decreases from childhood to adolescence and stabilizes after 30-40 years and at Fz the decrement finishes by 60 years and highly increases after this age. Regarding N2, latency did not covary with age but amplitude showed a significant decrement for both Cz and Fz. Results suggested reliable normative values for Cz and Fz electrode locations; however, changes in brain development and components topography over age should be considered in clinical practice.

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Section: Discussionmentioning

confidence: 99%

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

et al. 2014

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“…Similar to MMN, it may be that users do not utilise neural resources efficiently (Ramaekers et al 2009;Battisti et al 2010a;Battisti et al 2010b), and this is reflected by a delayed P3a latency. Alternatively, given that the latencies and peak amplitudes of MMN and P3a components increase sequentially when they are measured concurrently (Valkonen-Korhonen et al 2003;Javitt et al 2008), prolonged P3a latencies may be a consequence of an already delayed MMN latency.…”

Section: Discussionmentioning

confidence: 99%

“…A second limitation may be the use of overlapping windows for MMN and P3a components particularly during peak selection. However, latencies and peak amplitudes of MMN and P3 components increase sequentially when they are measured concurrently (ValkonenKorhonen et al 2003;Javitt et al 2008), safeguarding against incorrect peak selection (Valkonen-Korhonen et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Delayed preattentional functioning in early psychosis patients with cannabis use

et al. 2012

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“…In line with this, pharmacological studies suggest MMN reflects glutamatergic processes [60,61], whereas P3a amplitude is modulated by dopamine (and hence current anti-psychotic medications) [62,63]. Consistent with the findings for MMN, P3a amplitude correlates with cognitive and psychosocial functioning [59,64,65], and is reduced in schizophrenia [59,66], first episode psychosis [37, 41,64,67], and in at risk samples [36,37,39,41]. Thus P3a might provide an additional biomarker for psychosis but targeting different disease processes, and can be readily measured concurrently with MMN.…”

Section: The P3amentioning

confidence: 56%

114. Electrophysiological, Cognitive and Clinical Profiles of At-Risk Mental State: The Longitudinal Minds in Transition (MinT) Study

Schall¹,

Fulham²,

Atkinson³

et al. 2017

Biological Psychiatry

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The onset of schizophrenia is typically preceded by a prodromal period lasting several years during which sub-threshold symptoms may be identified retrospectively. Clinical interviews are currently used to identify individuals who have an ultra-high risk (UHR) of developing a psychotic illness with a view to provision of interventions that prevent, delay or reduce severity of future mental health issues. The utility of bio-markers as an adjunct in the identification of UHR individuals is not yet established. Several event-related potential measures, especially mismatch-negativity (MMN), have been identified as potential biomarkers for schizophrenia. In this 12-month longitudinal study, demographic, clinical and neuropsychological data were acquired from 102 anti-psychotic naive UHR and 61 healthy controls, of whom 80 UHR and 58 controls provided valid EEG data during a passive auditory task at baseline. Despite widespread differences between UHR and controls on demographic, clinical and neuropsychological measures, MMN and P3a did not differ between these groups. Of 67 UHR at the 12-month follow-up, 7 (10%) had transitioned to a psychotic illness. The statistical power to detect differences between those who did or did not transition was limited by the lower than expected transition rate. ERPs did not predict transition, with trends in the opposite direction to that predicted. In exploratory analysis, the strongest predictors of transition were measures of verbal memory and subjective emotional disturbance.

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Altered auditory processing in acutely psychotic never-medicated first-episode patients

Cited by 63 publications

References 84 publications

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

The development of the N1 and N2 components in auditory oddball paradigms: a systematic review with narrative analysis and suggested normative values

Delayed preattentional functioning in early psychosis patients with cannabis use

114. Electrophysiological, Cognitive and Clinical Profiles of At-Risk Mental State: The Longitudinal Minds in Transition (MinT) Study

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