Altered autonomic cardiac control in hypertrophic cardiomyopathy Role of outflow tract obstruction and myocardial hypertrophy

Limbruno, Ugo; Strata, G; Zucchi, Riccardo; Baglini, Roberto; Mengozzi, G; Balbarini, Alberto; Mariani, Mario

doi:10.1053/euhj.1997.0743

Cited by 23 publications

(18 citation statements)

References 38 publications

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“…However, for those patients with non-obstructive HCM -70% of our patients -Limbruno and collaborators have not found signifi cant difference in HRV spectral analysis either while comparing with normal individuals. The same was observed by Uemura and collaborators 17,22 .…”

Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupssupporting

confidence: 84%

“…Similar results were found by Limbruno and collaborators while using autonomic short-term stimulating protocols for HRV analysis. Sympathetic activity compromising was found to be higher in individuals with obstructive HCM 21,22 .…”

Section: Resultsmentioning

confidence: 89%

“…The fact is that even those who did fi nd the correlation of such data (particularly septal thickness) with autonomic function disorders did not report uniform results. Gillian and collaborators found correlation in parasympathetic activity compromising while Limbruno and collaborators observed sympathetic activity compromising 22,26 .…”

Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupsmentioning

confidence: 98%

“…Taking that inco account, the authors have chosen to use a protocol with short-term records, which allowed better control over stimuli in the two groups, which in its turn led to easer interpretation, as done by Limbruno and collaborators in their work 21,22 . They did not fi nd any compromising in parasympathetic activity, either; quite the opposite, they confi rmed sympathetic activity reduction at rest and at bend test in obstructive HCM.…”

Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupsmentioning

confidence: 99%

“…Opinions are controversial in that area, too, with some authors in defense of the relevance of such for autonomic modulation 22,26 and other opposing that assumption 16 . The fact is that even those who did fi nd the correlation of such data (particularly septal thickness) with autonomic function disorders did not report uniform results.…”

Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupsmentioning

confidence: 99%

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Avaliação da função autonômica na cardiomiopatia hipertrófica

Bittencourt

Benchimol-Barbosa

Neto

et al. 2005

Arq. Bras. Cardiol.

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50ms (pNN50) e LogAF] apresentaram menor redução durante o 3º estágio no grupo A, e o LogAF, um aumento no último estágio (p=0,027), indicando marcante atividade parassimpática neste grupo. A análise da VFC do grupo A não revelou diferença entre pacientes com maior hipertrofia ou diâmetro atrial. CONCLUSÃO: 1) ocorreu predomínio parassimpático durante estimulação autonômica nos pacientes com CMH; 2) não encontramos correlação entre VFC e as medidas ecocardiográficas analisadas.]]>

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Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 89%

Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupsmentioning

confidence: 98%

Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupsmentioning

confidence: 99%

Section: Fig 1 -Behavior Of Rrm During Stages In Both Groupsmentioning

confidence: 99%

See 3 more Smart Citations

Avaliação da função autonômica na cardiomiopatia hipertrófica

Bittencourt

Benchimol-Barbosa

Neto

et al. 2005

Arq. Bras. Cardiol.

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Disturbed Vascular Control in Hypertrophic Cardiomyopathy: Mechanisms and Clinical Significance

Campbell¹,

Morris‐Thurgood²,

Frenneaux³

2004

Diagnosis and Management of Hypertrophic Cardiomyopathy

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Association between severity of obstructive sleep apnea and high‐sensitivity C‐reactive protein in patients with hypertrophic obstructive cardiomyopathy

Wang

Guo

et al. 2020

Clinical Cardiology

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Background Obstructive sleep apnea (OSA) is highly prevalent in patients with hypertrophic obstructive cardiomyopathy (HOCM). Inflammatory responses are increased in patients with OSA, meanwhile, inflammation is also associated with adverse outcomes in HOCM. Hypothesis To investigate the association between severity of OSA and high‐sensitivity C‐reactive protein (hs‐CRP) in patients with HOCM. Methods Three hundred and ninteen patients with HOCM who underwent sleep evaluations at Fuwai Hospital were retrospectively included between February 2010 and December 2018. Data from baseline clinical characteristics and polysomnography studies were collected. Results OSA was present in 168 (52.7%). Patients with OSA were older, more likely to be male, had a higher body mass index and more clinical comorbidities. Patients with OSA had enlarged left ventricular diameter and similar left ventricular outflow tract obstruction compared with those without. In multivariate logistic analysis, apnea‐hypopnea index (OR, 1.024; 95% CI, 1.005‐1.044; P = .014), oxygen desaturation index (OR, 1.025; 95% CI, 1.004‐1.046; P = .018) and lowest oxygen saturation (OR, 0.951; 95% CI, 0.915‐0.989; P = .011) were independently associated with high risk hs‐CRP (>3 mg/L) after adjusting for confounders. In addition, decreasing lowest oxygen saturation (β = −.159, P = .004) was also independently correlated with increasing hs‐CRP concentrations in multivariate linear analysis after adjusting for confounders. Conclusions Severity of OSA was independently associated with elevated hs‐CRP levels in patients with HOCM. Further studies are needed to evaluate the effects of treating OSA on hs‐CRP as well as clinical outcomes in these patients.

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Altered autonomic cardiac control in hypertrophic cardiomyopathy Role of outflow tract obstruction and myocardial hypertrophy

Cited by 23 publications

References 38 publications

Avaliação da função autonômica na cardiomiopatia hipertrófica

Avaliação da função autonômica na cardiomiopatia hipertrófica

Disturbed Vascular Control in Hypertrophic Cardiomyopathy: Mechanisms and Clinical Significance

Association between severity of obstructive sleep apnea and high‐sensitivity C‐reactive protein in patients with hypertrophic obstructive cardiomyopathy

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