Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI

Zang, Yu‐Feng; He, Yong; Zhu, Chaozhe; Cao, Qingjiu; Sui, Manqiu; Liang, Meng; Tian, Lihong; Jiang, Tianzi; Wang, Yufeng

doi:10.1016/j.braindev.2006.07.002

Cited by 2,186 publications

(1,085 citation statements)

References 42 publications

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“…ALFF was proposed to measure the intensities of the moment-to-moment low-frequency fluctuations in the fMRI time series (Yu-Feng et al, 2007). ALFF, as well as its normalized version fALFF, is a useful approach with which to map the voxel-wise spatial distribution or regional variation of low-frequency fluctuations across the entire brain.…”

Section: Resultsmentioning

confidence: 99%

Alterations in regional homogeneity of resting-state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)

Huang

Peng

et al. 2016

Journal of Affective Disorders

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Section: Resultsmentioning

confidence: 99%

Alterations in regional homogeneity of resting-state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)

Huang

Peng

et al. 2016

Journal of Affective Disorders

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“…Then we follow the sample selection principle in [20] get the final data for 763 individuals (ASDs=360; TCs=403) from 14 centers. Frequency Fluctuations (ALFF) [70]. ALFF is defined as the mean square root of the power spectrum density over the low frequency band (usually 0.01,0.08 Hz).…”

Section: Numerical Experimentsmentioning

confidence: 99%

Randomized Structural Sparsity-Based Support Identification with Applications to Locating Activated or Discriminative Brain Areas: A Multicenter Reproducibility Study

Wang

Zhang

Zheng

et al. 2015

IEEE Trans. Auton. Mental Dev.

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“…Finally, together with the work showing an association between gross HM level and case status for diseases such as schizophrenia [274], autism [272] and ADHD [269,271,273], we suggest that HM may be considered a possible endophenotype for brain disorders, especially if the diseases are known or suspected to impact motor functions.…”

Section: Discussionmentioning

confidence: 99%

“…This limitation can be even more important in schizophrenia or ADHD, in which impulsiveness on Go-NoGo tasks is increased [270]. In addition, the proportion of ADHD and autism subjects excluded because of excessive (gross) head movements is significantly higher than for controls [269,[271][272][273]. In schizophrenia, head rotation in particular appears to be significantly higher among patients than healthy controls [274].…”

Section: Heritability Of Head Motion During Resting State Functionalmentioning

confidence: 98%

Breaking down the genetics of depression using brain endophenotypes

Couvy‐Duchesne¹

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The Queensland Brain Institute 2 Thesis AbstractThe objective of the work presented in this thesis was to extend our understanding of depression aetiology and to identify brain MRI endophenotypes of depression. Our work builds on previous research that highlighted the genetic relationships between stress, sex and depression. In addition, MRI measurements are heritable and do not relying on selfreport. As such, they represent promising endophenotypes that could help break down further the genetics of depression.Preliminary work involved reporting depression prevalence in a young adult Australian twin sample (N=2,773) as well as comorbidity with affective and substance use disorders (Chapter 1). In addition, we demonstrated the good psychometric properties of the SPHERE questionnaire, which provides self-reported measures of anxiety-depression and chronic fatigue. Properties of the scores include: i) stochastic ordering on the sum score, ii) limited sex and age bias through adolescence, iii) high internal consistency, iv) good 3 months test-retest, v) moderate heritability, vi) significant association with lifetime MDD, social anxiety and alcohol dependence diagnoses (Chapter 2).In an older sample of Australian twins (N=5,221, Chapter 3), we performed a direct test of the diathesis-stress hypothesis in depression, which states that stressors can mediate the effect of genetic predisposition (diathesis) on the disease risk. We used Polygenic Risk Scores as a measure of diathesis and report a significant interaction with personal stressful life events, supporting the idea that stress and predisposition have a multiplicative effect on the depression liability scale. This interaction may be different between sexes as suggested by the stratified analysis.We then performed 3 analyses of resting-state fMRI from which we showed that: 1) Head motion (HM) is reliable and heritable in addition to being a major confound in fMRI analyses. However, this is unlikely to greatly confound twin studies of resting-state functional connectivity (FC). As a by-product of the analysis we showed that FC in the Broca's areas networks exhibited low to moderate test-retest and heritability (Chapter 4).2) HM is phenotypically and genetically associated with ADHD scores of Inattention and Hyperactivity/Impulsivity. This leads to most head motion image processing options to reduce power and/or to induce a sampling bias in RS-fMRI studies of ADHD. We discussed ways of circumventing this problem, via volume pruning or multivariate analysis (Chapter 5). 33) Nuisance regression (global signal regression, CompCor and HM regression) options in RS-fMRI processing have a moderate impact on the test-retest of regional homogeneity. Independently of the processing options, the low to moderate intra-class coefficients estimated in our sample may be due to insufficient scanning time (5mins 20s) and would impair our statistical power to detect RS-fMRI endophenotypes of depression (Chapter 6).Rather, we focused on structural brain images and contributed sample...

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Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI

Cited by 2,186 publications

References 42 publications

Alterations in regional homogeneity of resting-state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)

Alterations in regional homogeneity of resting-state brain activity in patients with major depressive disorder screening positive on the 32-item hypomania checklist (HCL-32)

Randomized Structural Sparsity-Based Support Identification with Applications to Locating Activated or Discriminative Brain Areas: A Multicenter Reproducibility Study

Breaking down the genetics of depression using brain endophenotypes

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