Altered Biodistribution of Radiopharmaceuticals Used in Bone Scintigraphy

Zuckier, Lionel S.; Martineau, Patrick

doi:10.1053/j.semnuclmed.2014.07.007

Cited by 20 publications

(10 citation statements)

References 157 publications

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“…A biodistribution study was performed 3 hours after intravenous injection of 99m Tc-MDP to the animal model. In nuclear medicine, bone scintigraphy using 99m Tc-MDP is usually performed 2-5 hours post injection for allowing a clearance of administrated radiopharmaceutical from the intravascular compartment and from extracellular nonosseous soft tissues [12]. Biodistribution study ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetics Interaction of Non-Steroid Anti Inflammatory Drugs to <sup>99m</sup>Tc-MDP Radiopharmaceuticals for Bone Imaging and Its Biodistribution

et al. 2018

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Tc-MDP Meloxicam Sodium diclofenac 99m Tc-MDP has been developed as a radiopharmaceutical for bone imaging in nuclear medicine. A drug therapy can alter the pharmacokinetic profiles and biodistribution patterns of radiopharmaceuticals. To achieve an optimum diagnostic outcome, this research focused on pharmacokinetics interaction between two kinds of nonsteroidal anti-inflammatory drugs (NSAID) drugs, meloxicam and sodium diclofenac with 99m Tc-MDP using mice (Mus musculus). There were five groups of animal model and each group consists of three mice except for group II and III which consists of six mice. The groups were classified as untreated mice (I), mice treated with meloxicam for 3 days (II), treated with sodium diclofenac for 3 days (III), treated with meloxicam once or at onset (IV), and mice with sodium diclofenac once or at onset (V). Pharmacokinetics interaction and biodistribution test were conducted by injecting 100 µCi/100 µL 99m Tc-MDP intravenously. Blood samples were withdrawn from each mouse which were then weighted and counted using single channel analyzer. The %ID/g of 99m Tc-MDP in blood of untreated mice (I), mice treated with meloxicam (II) and sodium diclofenac (III) 5 minutes post injection were 3.71, 8.96 and 9.15 % respectively, then decrease to 0.12, 0.01, and 0.01 %, respectively, 24 hours post injection. The results of T-test showed there were no significant differences in distribution of 99m Tc-MDP in untreated mice (I) and in treated mice either with meloxicam (II) or sodium diclofenac (III). However, there was significant difference in elimination of 99m Tc-MDP in untreated mice (I) and in treated mice either with meloxicam (II) or sodium diclofenac (III). The bone uptakes of 99m Tc-MDP were 9.03 ± 0.41, 3.52 + 0.52, 3.62 + 0.45, 8.44 + 1.39, and 8.09 ± 0.86 % in group I, II, III, IV, and V, respectively. T-test showed there were significant differences in bone uptake of 99m Tc-MDP in mice with previously treated with meloxicam and sodium diclofenac for 3 days. From these result, it can be concluded that an administration of meloxicam and sodium diclofenac could accelerate elimination half-life that cause low uptake of 99m Tc-MDP radiopharmaceutical on the bone as the primary target. Therefore, it is necessary to follow up using image study to determine the significance of the effects on image quality.

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Section: Resultsmentioning

confidence: 99%

Pharmacokinetics Interaction of Non-Steroid Anti Inflammatory Drugs to <sup>99m</sup>Tc-MDP Radiopharmaceuticals for Bone Imaging and Its Biodistribution

et al. 2018

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“…The latter results in a relatively narrow waist making the entire sternum appear like a neck tie (Fig. 4 ) [ 9 ]. The pathophysiologic basis for such an appearance is due to accelerated bone turnover and is usually accompanied by other features of metabolic bone disease including increased tracer uptake in the axial skeleton, long bones, and periarticular areas with prominent calvaria, faint visualization of the kidneys, and beading of the costochondral junctions [ 10 ].…”

Section: Musculoskeletal Systemmentioning

confidence: 99%

The clothes maketh the sign

et al. 2016

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Pattern recognition is a key tool that enables radiologists to evoke certain diagnoses based on a radiologic appearance. In Shakespeare’s Hamlet, Polonius tells his son Laertes to dress well because “apparel oft proclaims the man”; this phrase is now expressed in modern parlance as “the clothes maketh the man”. Similarly in radiology, appearances are everything, and in the case of radiologic signs, occasionally “the clothes maketh the sign”. The radiologic signs described in this pictorial review resemble items of clothing, fabric types, headwear, or accessories and are found in the musculoskeletal, pulmonary, gastrointestinal, and genitourinary systems. These “clothing signs” serve as a useful visual trigger to help radiologists to identify particular disease entities.Teaching Points• Pattern recognition enables radiologists to evoke a diagnosis based on radiologic appearance.• The radiologic signs described in this review resemble clothing, fabric, or accessories.• These “clothing signs” serve as visual triggers that evoke particular disease entities.

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“…Ekstravaze olan aktivite subkutan dokulara infiltre olmazsa genellikle enjeksiyon alanında sınırları belirgin, tek bir aktivite şeklinde görülür. Antekübital bölgeden yapılan enjeksiyon sonrası subkutan dokularda anlamlı ekstravazasyon olursa, infiltre olan RF kısmen lenfatik dokular tarafından temizlendiği için bölgesel lenf nodları görülür 4,5 .…”

Section: Introductionunclassified

“…KS' de periartriküler tutulum karakteristiktir. KS' de aktivite tutulumu zamanla normale dönmektedir 5,11 .…”

Section: Introductionunclassified

Tc-99m MDP’nin intraarteryal enjeksiyonu

Salmanoglu¹,

Peksoy²

2016

Cukurova Medical Journal (Çukurova Üniversitesi Tıp Fakültesi Dergisi)

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AbstractÖz Bone scintigraphy is applied to evaluate abnormalities of axial skeleton and appendicular skeleton including osteomyelitis, prosthesis infection, prosthesis loosening, avascular necrosis, stress fracture, bone metastasis. Technetium-99m methylene diphosphonate (Tc-99m MDP) is most common used radiopharmaceutical. Injection of Tc-99m MDP should be done intravenous but it can be done intra-arterial, accidentally. After intraarterial injection of Tc-99m MDP, it cause prominent soft tissue uptake distal to the injection site. This situation can create confusion in the scintigraphic images. Usually, it imitate reflex sympathetic dystrophy, so differential diagnosis is important. The aim of this report is to present the appearance of inadvertent intra-arterial injection of Tc99m MDP.Kemik sintigrafisi, osteomiyelit, protez enfeksiyonu, protez gevşemesi, avasküler nekroz, stres fraktürü, kemik metastazı dahil aksiyel ve apendiküler iskeletin anormaliklerini değerlendirmek için uygulanır. Teknesyum99m metilen difosfonat (Tc-99m MDP) en sık kullanılan radyofarmasötiktir. Tc-99m MDP' nin enjeksiyonu intravenöz yapılmalıdır ancak kazara intraarteryal enjeksiyon yapılabilir. Tc-99m MDP' nin intraarteryal enjeksiyonundan sonra, enjeksiyon alanının distalinde belirgin yumuşak doku tutulumuna neden olur. Bu durum sintigrafik görüntülerde karışıklık yaratabilir. Genellikle refleks sempatik distrofiyi taklit eder, bu yüzden ayırıcı tanı önemlidir.

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Altered Biodistribution of Radiopharmaceuticals Used in Bone Scintigraphy

Cited by 20 publications

References 157 publications

Pharmacokinetics Interaction of Non-Steroid Anti Inflammatory Drugs to <sup>99m</sup>Tc-MDP Radiopharmaceuticals for Bone Imaging and Its Biodistribution

Pharmacokinetics Interaction of Non-Steroid Anti Inflammatory Drugs to <sup>99m</sup>Tc-MDP Radiopharmaceuticals for Bone Imaging and Its Biodistribution

The clothes maketh the sign

Tc-99m MDP’nin intraarteryal enjeksiyonu

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