Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis

Elsayed, Noha M.; Kubesy, A. A.; Salem, Noha Y.

doi:10.1007/s00580-019-03067-x

Cited by 14 publications

(11 citation statements)

References 27 publications

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“…At the end of treatment, the value declined to 3.21 ± 0.25nM/mL.The oxidation of polyunsaturated fatty acids of erythrocyte cell membrane by the free radicals resulted in lipid peroxidation. In agreement with the present findings, elevation in MDA levels associated with HGE was also reported by Elsayed et al (2020). After treatment, all the animals showed a significant decrease in the mean MDA value compared to pre-treatment value.…”

Section: Lipid Peroxidation Levelsupporting

confidence: 93%

Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis

Nath¹,

Unny²,

Rajan³

et al. 2023

Journal of Veterinary and Animal Sciences

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The present study was conducted to evaluate the alterations in oxidative stress parameters in dogs suffering from haemorrhagic gastroenteritis (HGE). Dogs presented with vomiting and diarrhoea were screened and fifteen animals with signs suggestive of HGE were included in the study. The oxidative stress parameters, serummalondialdehyde (MDA) level, total antioxidant status (TAS) and plasma glutathione peroxidase (GSH-Px) activity were studied. The values were compared with the values from six apparently healthy dogs. A significant increase was noticed in the mean values of serum MDA and TAS of diseased animals at the time of presentation when compared to healthy animals whereas the activity of plasma GSH-Px was found to be lower than in healthy dogs. Supplementation with N-acetyl cysteine @ 70 mg/kg or five days was found effective in managing the oxidative injury in the affected animals.

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Section: Lipid Peroxidation Levelsupporting

confidence: 93%

Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis

Nath¹,

Unny²,

Rajan³

et al. 2023

Journal of Veterinary and Animal Sciences

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“…The state of elevated oxidant byproduct and reduction of antioxidant counterparts is known as oxidative stress ( 24 ). Malondialdehyde (MDA) is a lipid peroxidation byproduct that is usually measured to evaluate the oxidant arm in the body ( 25 ), while total antioxidant capacity (TAC) is used to crude estimate the status of the antioxidant system in the body ( 26 ).…”

Section: Introductionmentioning

confidence: 99%

Corneal Ulcer in Dogs and Cats: Novel Clinical Application of Regenerative Therapy Using Subconjunctival Injection of Autologous Platelet-Rich Plasma

et al. 2021

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Background: Corneal ulcer could be a major source of distress in small animals, with many contributing agents. In recent years, few studies evaluated the efficacy of platelet-rich plasma (PRP) in healing corneal ulcers.Aim: This study aimed to assess the ability of subconjunctival injection of autologous PRP in the treatment of corneal ulcers in dogs and cats as well as estimate the expression of matrix metalloproteinase (MMP)-2, MMP-9, and oxidative stress biomarkers in these patients.Methods: A total number of 28 animals (16 cats and 12 dogs) were enrolled in this study. Each animal was subjected to clinical, neurologic, and ophthalmic examinations where the type of ulcer was documented. Tear samples were collected for evaluation of oxidative biomarkers and MMPs; conjunctival swabs were taken to identify the involved organism. PRP was prepared from each animal and given as subconjunctival injection; numbers of injections were done according to case response. Clinical follow-up was done and documented for each case.Results: In cat patients, female and Persian cats were most affected; unilateral and superficial ulcers were most recorded. In male dogs, unilateral, and superficial ulcers were most recorded. FHV-1 was most identified in cats, while Staphylococcus aureus was most identified in dogs. Numbers of injections needed to achieve healing were recorded, with 50% of dogs needing two injections with 1-week intervals and 50% of cats needed three injections with 1-week intervals. Alterations in both oxidative biomarkers and MMPs were recorded in affected animals.Conclusion: The use of autologous PRP as a subconjunctival injection in treating corneal ulcers in dogs and cats is effective. The number of injections is the case and corneal ulcer type-dependent.Clinical Significance: Autologous PRP as a subconjunctival injection in treating corneal ulcer is a relatively cheap, safe method and can be done in the clinical setting.

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“…Zinc is an important trace element. It plays an integral role in the antioxidant system as it is a chief component of Zn-Cu Superoxide dismutase (SOD), a frontrunner in the antioxidant system (Elsayed et al, 2020). In this study, a significant decrease in zinc was recorded in affected patients.…”

Section: Resultsmentioning

confidence: 72%

“…Oxidative stress has recently been implicated in numerous equine diseases (Abdelnaby et al, 2020) and allergic skin diseases in other animal models (Kubesy et al, 2017). When a disturbance to equilibrium between oxidant and antioxidant sides occurs, oxidative stress will ensue (Elsayed et al, 2020). In one study of eczema, there was an implication that there is a strong association between eczema pathogenesis and increased malondialdehyde (MDA) levels (Amin et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Hematological and Oxidant/Antioxidant Status in Recurrent Equine Eczema Of Egyptian Horses

Jaheen¹,

Salem²,

Elsherif³

2022

AAVS

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Altered blood oxidative stress biomarkers in association with canine parvovirus enteritis

Cited by 14 publications

References 27 publications

Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis

Evaluation of oxidative stress and efficacy of antioxidant therapy in dogs with haemorrhagic gastroenteritis

Corneal Ulcer in Dogs and Cats: Novel Clinical Application of Regenerative Therapy Using Subconjunctival Injection of Autologous Platelet-Rich Plasma

Hematological and Oxidant/Antioxidant Status in Recurrent Equine Eczema Of Egyptian Horses

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