Altered Bone Metabolic Markers In Type 2 Diabetes Mellitus: Impact of Glycemic Control

Sultan, Entessar; Taha, Inass M.; Saber, Lobna M.

doi:10.1016/s1658-3612(08)70059-3

Cited by 14 publications

(15 citation statements)

References 35 publications

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“…This study demonstrated a significantly high concentration of salivary phosphorus in DM patients compared to controls. Similar results were seen by Sultan E et al, studies [19]. This might be due to reduction in salivary flow and release of binded phosphorus into the saliva from the degraded periodontal proteins in DM patients.…”

Section: Resultssupporting

confidence: 86%

A Comparative Study of Serum and Salivary Biochemical Markers in Diabetes Mellitus Type Ii With Healthy Individuals

Srivastava

Agarwal

Chandel

2020

IJMBS

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Introduction: Blood is the gold standard body fluid for diagnosis of Diabetes Mellitus (DM) but saliva can offers an alternative to serum as a biological fluid for diagnostic purposes because it contains serum constituents. People wants that medical science should promote non invasive method for diagnosis of disease. Aim: The study was conducted to estimate and compare serum and salivary glucose, total protein, calcium and phosphorus levels in DM type ll and healthy subjects and to evaluate whether saliva can be used as a diagnostic fluid in DM type ll patients. The target population of this study was individuals who have Type-2 DM for different period of time and resident INDORE. Materials & Methods: Study consisted of 50 subjects from OPD/IPD Index Medical College & Research Center, INDORE, MADHYA PRADESH, India. The study groups were divided into Group I-25 DM patients (TypeII) and Group II-25 healthy subjects. The saliva and serum samples were collected from each subject and levels of different biochemical parameters were estimated. Result: were noted. On comparing values in saliva and serum, among two groups, a significant difference (p<0.005) was found between few of them. Conclusion: Values regarding blood and salivary biochemical parameters were distinctly different between two groups suggesting salivary parameters can be used as a diagnostic alternative to blood parameters for diabetes mellitus.

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Section: Resultssupporting

confidence: 86%

A Comparative Study of Serum and Salivary Biochemical Markers in Diabetes Mellitus Type Ii With Healthy Individuals

Srivastava

Agarwal

Chandel

2020

IJMBS

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“…The measurement of BAP has advantages over OC measurement because of its relatively long half-life in vivo and is unaffected by diurnal variation. [ 4 ] OC/BAP ratio can be one of the potential markers clinically used to predict fracture risk in type 2 diabetes mellitus men,[ 5 ] but only one study has reported this till now, and hence, our study assumes relevance in the measurement of OC/BAP ratio in type 2 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 98%

Association of glycemic status with bone turnover markers in type 2 diabetes mellitus

Kulkarni

Meenatchi

Rajagambeeram

et al. 2017

Int J App Basic Med Res

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Context:Type 2 diabetes mellitus has profound implications on the skeleton. Even though bone mineral density is increased in type 2 diabetes mellitus patients, they are more prone for fractures. The weakening of bone tissue in type 2 diabetes mellitus can be due to uncontrolled blood sugar levels leading to high levels of bone turnover markers in blood.Aims:The aim of this study is to find the association between glycemic status and bone turnover markers in type 2 diabetes mellitus.Settings and Design:This case–control study was carried out in a tertiary health care hospital.Subjects and Methods:Fifty clinically diagnosed type 2 diabetes mellitus patients in the age group between 30 and 50 years were included as cases. Fifty age- and gender-matched healthy nondiabetics were included as controls. Patients with complications and chronic illness were excluded from the study. Depending on glycated hemoglobin (HbA1c) levels, patients were grouped into uncontrolled (HbA1c >7%, n = 36) and controlled (HbA1c <7%, n = 14) diabetics. Based on duration of diabetes, patients were grouped into newly diagnosed, 1–2 years, 3–5 years, and >5 years. Serum osteocalcin (OC), bone alkaline phosphatase (BAP), acid phosphatase (ACP), and HbA1c levels were estimated. OC/BAP and OC/ACP ratio was calculated.Statistical Analysis Used:Student's t-test, analysis of variance, and Chi-square tests were used for analysis. Receiver operating characteristic (ROC) curve analysis was done for OC/BAP and OC/ACP ratios.Results:Serum OC, HbA1c, and OC/BAP ratio were increased in cases when compared to controls and were statistically significant (P < 0.001). OC/ACP ratio was decreased in type 2 diabetes mellitus and was statistically significant (P = 0.01). In patients with >5-year duration of diabetes, HbA1c level was high and was statistically significant (P < 0.042). BAP levels were high in uncontrolled diabetics but statistically not significant. ROC curve showed OC/BAP ratio better marker than OC/ACP ratio.Conclusions:Uncontrolled type 2 diabetes mellitus affects bone tissue resulting in variations in bone turnover markers. Bone turnover markers are better in predicting recent changes in bone morphology and are cost effective.

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“…Hence they suggested that oral supplementation of all these ions other than diet is recommended in type2 diabetes. Another study, Sultan et al [11], also reported that in type2 diabetes patients the mean serum calcium levels were significantly lower than the control group, and suggested that, the reduction in serum calcium levels were most probably due to several factors: reduction in insulin level which impairs bone formation due to its stimulatory action on osteoblast proliferation and impairment of calcium homeostasis, and hyperglycemia which increases calcium and phosphorus excretion in urine being proportional to the degree of glucosuria. However, in contrast to our study, Mohammed and Abdrabo [8] reported that Sudanese diabetic type2 patients have higher serum calcium levels, and mentioned that the increased levels of serum calcium in type2 diabetic patients may play an important role in the vascular complications, such as hypertension, atherosclerosis, and microangiopathy.…”

Section: Discussionmentioning

confidence: 94%

“…In the bone, PTH activates a process known as bone resorption, in which activated osteoclasts break down bone and subsequently release Ca 2+ into the serum [10]. Sultan et al [11] have shown that the reduction in serum calcium level in type2 diabetes mellitus is most probably due to hyperglycemia which increases calcium and phosphorus excretion in urine which is proportional to the degree of glucosuria, hypercalciuria by osmotic diuresis caused stimulation of bone resorption caused by secondary hyperparathyroidism. In response to urinary calcium loss, PTH secretion is mildly but significantly stimulated to maintain serum calcium concentrations.…”

Section: Introductionmentioning

confidence: 99%

Serum Calcium Levels in Correlation with Glycated Hemoglobin in Type 2 Diabetic Sudanese Patients

Hassan¹,

Elsheikh²,

Rahman³

et al. 2016

adm

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The present work is a cross-sectional study aimed to evaluate the serum levels of calcium and Glycated Hemoglobin (HbA1c) of (40) patients with type 2 diabetes mellitus, attending Center clinic in Khartoum North-Sudan, and (40) apparently healthy (non-diabetic) volunteers as control group. Age and sex of the test group were matched with the control group. Serum levels of calcium were measured by auto analyzer Bs-200 (instruments and reagents from Mindray Company) and HbA1c amount was measured by CERA-STAT TM 4000 Analyzer (reagents and instruments from Ceragem Medisys Company). Data was analyzed using SPSS. The results showed a significant reduction in the mean of serum calcium level of the diabetic group when compared with the control group (p value <0.05), whereas HbA1c was increased in diabetic patients (type 2) compared to the control group (p. value <0.05). However there was a good negative correlation between the serum calcium levels and HbA1c in diabetic patients. The results revealed that the increase in HbA1c, in diabetics of type 2 diabetes mellitus, is accompanied by a significant decrease in calcium serum levels, so uncontrolled diabetic patients are at risk of hypocalcaemia compared to controlled patients. This effect was not influenced by gender or duration of diabetes in the studied group.

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Altered Bone Metabolic Markers In Type 2 Diabetes Mellitus: Impact of Glycemic Control

Cited by 14 publications

References 35 publications

A Comparative Study of Serum and Salivary Biochemical Markers in Diabetes Mellitus Type Ii With Healthy Individuals

A Comparative Study of Serum and Salivary Biochemical Markers in Diabetes Mellitus Type Ii With Healthy Individuals

Association of glycemic status with bone turnover markers in type 2 diabetes mellitus

Serum Calcium Levels in Correlation with Glycated Hemoglobin in Type 2 Diabetic Sudanese Patients

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