Altered Brain Activation by a False Recognition Task in Young Abstinent Patients With Alcohol Dependence

Akine, Yoshihide; Kato, Masaaki; Muramatsu, Taro; Umeda, Satoshi; Mimura, Masaru; Asai, Yoshiyuki; Tanada, Shuji; Obata, Takayuki; Ikehira, Hiroo; Kashima, Haruo; Suhara, Tetsuya

doi:10.1111/j.1530-0277.2007.00453.x

Cited by 25 publications

(18 citation statements)

References 63 publications

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“…Functional MRI during a Stop-Signal task was carried out, showing alcoholic patients to have altered activity in a number of cortical structures, especially a decreased activation in the dorsolateral prefrontal cortex during response inhibition, error processing, and posterror behavioral adjustment. These findings are in line with previous studies [29,30] .…”

Section: Studies Assessing Impulsivity In Detoxified Patientssupporting

confidence: 83%

Laboratory Paradigms of Impulsivity and Alcohol Dependence: A Review

et al. 2010

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Impulsivity can be defined as choosing a smaller, immediate reward over a larger, delayed reward. From this perspective, addictive behaviors such as substance abuse and pathological gambling reflect a series of impulsive choices. However, impulsivity is not a homogeneous construct. Laboratory measures of impulsivity reflect two types of processes. The first is related to behavioral inhibition and refers to an individual’s ability to appropriately inhibit thoughts or actions. The second is the delay of reward dimension, namely the degree to which immediate (rewarding) consequences have more control over an individual’s behavior than consequences that are delayed. In this review, we describe how alcohol is associated with significant impairments in these paradigms. We also suggest that they may have a role in the development of alcohol dependence. These results are in agreement with a model in which delay of gratification might be a marker for early use and/or abuse of alcohol, whereas impairment in behavioral inhibition might be a marker for maintained use in time and, therefore, for progression towards alcohol dependence.

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Section: Studies Assessing Impulsivity In Detoxified Patientssupporting

confidence: 83%

Laboratory Paradigms of Impulsivity and Alcohol Dependence: A Review

et al. 2010

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“…These studies included stimulant (n=13), alcohol (n=10), cannabis (n=6), polysubstance (n=4), opiate (n=3), and cocaine (n=1) abuse/dependence also varying in terms of active or abstinent users. Despite the variability in identified substances of use and abuse, these patients relative to other disorders tended to show more uniform attenuations of the multiple demand network and related regions (e.g., Akine et al, 2007; Bach et al, 2012; Bolla et al, 2003; Bolla et al, 2005). …”

Section: Clues To Core Cognitive Control Dysfunction Common Across Psmentioning

confidence: 91%

Transdiagnostic impairment of cognitive control in mental illness

McTeague

Goodkind

Etkin

2016

Journal of Psychiatric Research

276

180

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Intact cognitive control or executive function has characteristic patterns in both behavior and functional neurocircuitry. Functional neuroimaging studies have shown that a frontal-cingulate-parietal-insular (i.e., “multiple demand”) network forms a common functional substrate undergirding successful adaptation to diverse cognitive processing demands. Separate work on intact neurocognitive performance implicates a higher order factor that largely explains performance across domains and may reflect trait cognitive control capacity. In the current review we highlight findings from respective psychiatric disorders (i.e., psychotic, bipolar and unipolar depressive, anxiety, and substance use disorders) suggesting that cognitive control perturbations amidst psychopathology are most pronounced within these common brain and behavioral indices of adaptive cognitive functioning and moreover, are evident across disorders (i.e., transdiagnostically). Specifically, within each of the disorder classes impairments are consistent in the multiple demand network across a wide range of cognitive tasks. While severity varies between disorders, broad as opposed to domain-specific impairments consistently emerge in neurocognitive performance. Accumulating findings have revealed that phenotypically diverse psychiatric disorders share a common factor or vulnerability to dysfunction that is in turn related to broad neurocognitive deficits. Furthermore, we have observed that regions of the multiple demand network, which overlap with the salience network (dorsal anterior cingulate and bilateral anterior insula) are characterized by reduced gray matter transdiagnostically and predict weaker neurocognitive performance. In summary, transdiagnostic (as opposed to disorder-specific) patterns of symptomatic distress and neurocognitive performance deficits, concurrent with parallel anomalies of brain structure and function may largely contribute to the real-world socio-occupational impairment common across disorders.

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“…In an fMRI study, Akine et al (2007) employed a long-term false-recognition memory paradigm comparing alcoholics to controls on task performance and brain activation. Although the researchers did not find alcoholics to be impaired on the task, they did find differing patterns of brain activity between the groups.…”

Section: The Five Functional Domainsmentioning

confidence: 99%

“…All impairments are compared to healthy controls. Abbreviations: ADC, apparent diffusion coefficient; FA, fractional anisotropy; MD, mean diffusivity. VOLUMETRICIMPAIRMENTS VOLUMETRICRECOVERY TOTAL BRAIN VOLUME Pfefferbaum et al, 1992;Mann et al, 2005; Chen et al, 2012 Gazdzinski et al, 2005a(1 month follow-up);Mann et al, 2005 (5week follow-up) FUNCTIONAL BRAIN ABNORMALITIES TOTAL GRAY MATTER Fein et al, 2009; Chen et al, 2012 Total Cortical Gray Matter Pfefferbaum et al, 1992;Pfefferbaum et al, 2001b;Makris et al, 2008Pfefferbaum et al, 1992; Frontal Lobes Pfefferbaum et al, 1998;Gazdzinski et al, 2005b Prefrontal Pfefferbaum et al, 1992 Sullivan, 2003 Dorsolateral prefrontal cortex Cardenas et al, 2007;Chanraud et al, 2007;Makris et al, 2008 Pfefferbaum et al, 2001a (2-Back Task); Akine et al, 2007(Modified False Recognition Task);Parks et al, 2010 (Finger-Tapping) Ventrolateral prefrontal cortex …”

Section: Appendix Tablementioning

confidence: 99%

Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholism

Oscar‐Berman

Valmas

Sawyer

et al. 2014

Handbook of Clinical Neurology

143

128

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Long-term chronic alcoholism is associated with disparate and widespread residual consequences for brain functioning and behavior, and alcoholics suffer a variety of cognitive deficiencies and emotional abnormalities. Alcoholism has heterogeneous origins and outcomes, depending upon factors such as family history, age, gender, and mental or physical health. Consequently, the neuropsychological profiles associated with alcoholism are not uniform among individuals. Moreover, within and across research studies, variability among participants is substantial and contributes to characteristics associated with differential treatment outcomes after detoxification. In order to refine our understanding of alcoholism-related impaired, spared, and recovered abilities, we focus on five specific functional domains: (1) memory, (2) executive functions, (3) emotion and psychosocial skills, (4) visuospatial cognition, and (5) psychomotor abilities. The brain systems that are most vulnerable to alcoholism are the frontocerebellar and mesocorticolimbic circuitries. Over time, with abstinence from alcohol, the brain appears to become reorganized to provide compensation for structural and behavioral deficits. By relying on a combination of clinical and scientific approaches, future research will help to refine the compensatory roles of healthy brain systems, the degree to which abstinence and treatment facilitate the reversal of brain atrophy and dysfunction, and the importance of individual differences to outcome.

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Altered Brain Activation by a False Recognition Task in Young Abstinent Patients With Alcohol Dependence

Cited by 25 publications

References 63 publications

Laboratory Paradigms of Impulsivity and Alcohol Dependence: A Review

Laboratory Paradigms of Impulsivity and Alcohol Dependence: A Review

Transdiagnostic impairment of cognitive control in mental illness

Profiles of impaired, spared, and recovered neuropsychologic processes in alcoholism

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