Altered Brain Function and Causal Connectivity Induced by Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Disorder

Guan, Muzhen; Wang, Zhongheng; Shi, Yanru; Xie, Yangli; Ma, Zhengliang; Liu, Zirong; Liu, Junchang; Gao, Xinyu; Tan, Qingrong; Wang, Huaning

doi:10.3389/fnins.2022.855483

Cited by 10 publications

(3 citation statements)

References 61 publications

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“…Studies have shown that cognitive behavioral therapy aims to regulate emotions mainly by enhancing prefrontal function [ 44 ]. Another study showed that the function and metabolism of the middle frontal gyrus were significantly higher in MDD patients after antidepressant treatment, suggesting that the increased ReHo of the middle frontal gyrus may be an important marker of depression remission [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder

Sun

Gao

et al. 2022

Brain Sciences

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In this study, we observed the sex differences in functional brain activity in patients with recurrent depressive disorder (RDE) and assessed the correlation between abnormal functional brain activity changes and clinical symptoms. A total of 40 patients with RDE (19 male and 21 female) and 42 healthy controls (HCs) (20 male and 22 female) met the inclusion criteria. Analysis of images using regional homogeneity (ReHo) and further analysis of the correlation between abnormal brain areas and clinical symptoms of the different sexes with RDE groups were carried out. For the main effects of sex (male vs. female), there were statistically significant differences in ReHo among the four groups in the right middle temporal gyrus, right thalamus, and left posterior cerebellar lobe. For the effects of the sex-by-group interaction, there were statistically significant differences in ReHo among the four groups in the left middle frontal gyrus, left precentral gyrus, and right insula. Post hoc analyses showed that compared with the female RDE group, the male RDE group had decreased ReHo in the left middle frontal gyrus and right insula. In the female RDE group, the ReHo values of the left middle frontal gyrus were positively correlated with the 17-item Hamilton Rating Scale for Depression (HAMD-17) scores. This study provides new insights into the clinical targeting of different sexes for RDE.

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Section: Discussionmentioning

confidence: 99%

A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder

Sun

Gao

et al. 2022

Brain Sciences

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“…The GCA method defines causal effects by examining whether the prior neural activity in one seed region predicts the activity in another region. GCA can be applied to time-series rs-fMRI data to identify the directional effective connectivity of functional interactions among brain regions ( Guan et al, 2022 ), and we employed it as such.…”

Section: Introductionmentioning

confidence: 99%

Impaired effective functional connectivity in the social preference of children with autism spectrum disorder

Deng,

Tan,

Guo

et al. 2024

Front. Neurosci.

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BackgroundThe medial prefrontal cortex (mPFC), amygdala (Amyg), and nucleus accumbens (NAc) have been identified as critical players in the social preference of individuals with ASD. However, the specific pathophysiological mechanisms underlying this role requires further clarification. In the current study, we applied Granger Causality Analysis (GCA) to investigate the neural connectivity of these three brain regions of interest (ROIs) in patients with ASD, aiming to elucidate their associations with clinical features of the disorder.MethodsResting-state functional magnetic resonance imaging (rs-fMRI) data were acquired from the ABIDE II database, which included 37 patients with ASD and 50 typically developing (TD) controls. The mPFC, Amyg, and NAc were defined as ROIs, and the differences in fractional amplitude of low-frequency fluctuations (fALFF) within the ROIs between the ASD and TD groups were computed. Subsequently, we employed GCA to investigate the bidirectional effective connectivity between the ROIs and the rest of the brain. Finally, we explored whether this effective connectivity was associated with the social responsiveness scale (SRS) scores of children with ASD.ResultsThe fALFF values in the ROIs were reduced in children with ASD when compared to the TD group. In terms of the efferent connectivity from the ROIs to the whole brain, the ASD group exhibited increased connectivity in the right cingulate gyrus and decreased connectivity in the right superior temporal gyrus. Regarding the afferent connectivity from the whole brain to the ROIs, the ASD group displayed increased connectivity in the right globus pallidus and decreased connectivity in the right cerebellar Crus 1 area and left cingulate gyrus. Additionally, we demonstrated a positive correlation between effective connectivity derived from GCA and SRS scores.ConclusionImpairments in social preference ASD children is linked to impaired effective connectivity in brain regions associated with social cognition, emotional responses, social rewards, and social decision-making. This finding further reveals the potential neuropathological mechanisms underlying ASD.

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“… 23 Moreover, using voxel-based analyses, changes in brain activity in some regions implicated in the pathology of neurological and psychiatric disorders have been correlated with therapeutic effects. 24 , 25 However, few studies have employed voxel-based analysis to map the modulating effect of taVNS.…”

Section: Introductionmentioning

confidence: 99%

Mapping the modulating effect of transcutaneous auricular vagus nerve stimulation on voxel-based analyses in patients with first-episode major depressive disorder: a resting-state functional magnetic resonance imaging study

He¹,

Li²,

Wang³

et al. 2023

Brazilian Journal of Psychiatry

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Introduction: Seed-based analysis has shown that transcutaneous auricular vagus nerve stimulation (taVNS) can modulate the dysfunctional brain network in patients with major depressive disorder (MDD). However, the voxel-based neuropsychological mechanism of taVNS on patients with first-episode MDD is poorly understood. The objective of this study was to assess the effects of an 8-week course of taVNS on patients with first-episode MDD. Methods: Twenty-two patients with first-episode MDD accepted an 8-week course of taVNS treatment. Resting-state functional magnetic resonance imaging (rs-fMRI) scans were performed before and after treatment. Voxel-based analyses were performed to characterize spontaneous brain activity. Healthy controls (n=23) were recruited to minimize test-retest effects. Analysis of covariance (ANCOVA) was performed to ascertain treatment-related changes. Then, correlations between changes in brain activity and the Hamilton Depression Rating Scale (HAM-D)/Hamilton Anxiety Scale (HAM-A) remission rate were estimated. Results: Significant group-by-time interactions on voxel-based analyses were observed in the inferior ventral striatum (VSi) and precuneus. Post-hoc analyses showed that taVNS inhibited higher brain activity in the VSi, while upregulating it in the precuneus. Functional connectivity (FC) between the VSi and precuneus decreased. Positive correlations were found between the HAM-D remission rate and changes in brain activity in the VSi. Conclusion: taVNS reduced the FC between VSi and precuneus by normalizing the abnormal spontaneous brain activity of VSi in first-episode MDD patients.

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Altered Brain Function and Causal Connectivity Induced by Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Disorder

Cited by 10 publications

References 61 publications

A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder

A Study of Differential Resting-State Brain Functional Activity in Males and Females with Recurrent Depressive Disorder

Impaired effective functional connectivity in the social preference of children with autism spectrum disorder

Mapping the modulating effect of transcutaneous auricular vagus nerve stimulation on voxel-based analyses in patients with first-episode major depressive disorder: a resting-state functional magnetic resonance imaging study

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