Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study

Liu, Daihong; Duan, Shuhua; Zhou, Changyu; Wei, Ping; Chen, Lihua; Yin, Xuntao; Zhang, Jiuquan; Wang, Jian

doi:10.3389/fnagi.2018.00055

Cited by 42 publications

(30 citation statements)

References 54 publications

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“…DC quantifies local degree, which measures the centrality of every voxel in the human brain connectome ( 22 , 24 ). The increased DC may imply the transition from an economic connection to the costly connection; that is, brain regions with high energy-consumption such as brain hubs can be reconfigured to meet different and variable cognitive needs through negotiations between connection costs and the topological characteristics of the networks ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

“…DC has been widely used to quantify node features of networks, and increased DC regions are defined as functional hubs (22). Previous researches using DC analysis showed altered brain functional hubs and connectivity in T2DM subjects (5,23,24). However, subjects enrolled in these studies had clinical cognitive impairment or lacked cognitive assessment.…”

Section: Introductionmentioning

confidence: 99%

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Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Liang

Tan

et al. 2020

Front. Neurol.

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Background: Type 2 diabetes mellitus (T2DM)-related cognitive decline is associated with neuroimaging changes. However, only a few studies have focused on early functional alteration in T2DM prior to mild cognitive impairment (MCI). This study aimed to investigate the early changes of global connectivity patterns in T2DM by using a resting-state functional magnetic resonance imaging (rs-fMRI) technique. Methods: Thirty-four T2DM subjects and 38 age-, sex-, and education-matched healthy controls (HCs) underwent rs-fMRI in a 3T MRI scanner. Degree centrality (DC) was used to identify the functional hubs of the whole brain in T2DM without MCI. Then the functional connectivity (FC) between hubs and the rest of the brain was assessed by using the hub-based approach. Results: Compared with HCs, T2DM subjects showed increased DC in the right cerebellum lobules III-V. Hub-based FC analysis found that the right cerebellum lobules III-V of T2DM subjects had increased FC with the right cerebellum crus II and lobule VI, the right temporal inferior/middle gyrus, and the right hippocampus. Conclusions: Increased DC in the right cerebellum regions III-V, as well as increased FC within cerebellar regions and ipsilateral cerebrocerebellar regions, may indicate an important pathophysiological mechanism for compensation in T2DM without MCI.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Liang

Tan

et al. 2020

Front. Neurol.

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“…Previous studies have also confirmed that DC has a high sensitivity, specificity, and test-retest reliability, (Zuo and Xing 2014) and it has been increasingly used in many disorders associated with cognitive impairment, such as obstructive sleep apnea, diabetes, Parkinson's, and Alzheimer's disease. (Li et al 2016;Liu et al 2018;Wang et al 2018;Guo et al 2016) Therefore, the voxel-wise DC can help us investigate the intrinsic function hubs that may be associated with cognitive impairment in COPD.…”

Section: Introductionmentioning

confidence: 99%

Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study

Xin

et al. 2019

Brain Imaging and Behavior

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Chronic obstructive pulmonary disease (COPD) affects a large population and is closely associated with cognitive impairment. However, the mechanisms of cognitive impairment in COPD patients have not been unraveled. This study investigated the change in patterns of intrinsic functional hubs using a degree centrality (DC) analysis. The connectivity between these abnormal hubs with the remaining brain was also investigated using functional connectivity (FC). Nineteen stable patients with COPD and 20 normal controls(NC) underwent functional magnetic resonance imaging (MRI) examinations and clinical and neuropsychologic assessments. We measured the voxel-wise DC across the whole brain gray matter and the seed-based FC between these abnormal hubs in the remaining brain matter; the group difference was calculated. A partial correlation analysis was performed to assess the relationship between the abnormal DC and clinical variables in COPD patients. Compared to NC, the patients with COPD exhibited significantly decreased DC in the right lingual gyrus (LG), bilateral supplementary motor area (SMA), and right paracentral lobule (PCL). A further seed-based FC analysis found that COPD patients demonstrated significantly decreased FC between these abnormal hubs in several brain areas, including the left cerebellum anterior lobe, left lingual gyrus, left fusiform gyrus, right insula, right inferior frontal gyrus, limbic lobe, cingulate gyrus, left putamen, lentiform nucleus, right precuneus, and right paracentral lobule. A partial correlation analysis showed that the decreased DC in the right PCL was positively correlated with the FEV1 and FEV1/FVC, and the decreased DC in the SMA was positively correlated with naming and pH in COPD patients. This study demonstrates that there are intrinsic functional hubs and connectivity alterations that may reflect the aberrant information communication in the brain of COPD patients. These findings may help provide new insight for understanding the mechanisms of COPD-related cognitive impairment from whole brain functional connections.

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“…Previous studies had investigated regional CBF changes in the right-handed subjects with cerebrovascular diseases in the postcentral gyrus and found that the left somatosensory cortex has a dominant role in sensorimotor integration for complex finger movements (25), whereas visuospatial is lateralized to the right hemisphere (26). Previous fMRI studies also confirmed the decreased connectivity among the right precentral gyrus and bilateral lateral occipital cortices in diabetes (27). Since all the subjects in this study were right-handed, we cannot rule out the influence of cerebral dominance in the observed CBF asymmetries.…”

Section: Discussionmentioning

confidence: 87%

Disrupted Regional Cerebral Blood Flow in Children With Newly-Diagnosed Type 1 Diabetes Mellitus: An Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Study

et al. 2020

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Object: Diabetes is associated with cerebral vascular dysfunction and increased vascular cognitive impairment. The objective of this study was to use arterial spin labeling (ASL) perfusion-weighted magnetic resonance imaging to investigate whether cerebral perfusion was changed in newly-diagnosed children with type 1 diabetes mellitus (T1DM) and the possible relationship between aberrant cerebral blood flow (CBF) with cognitive as well as clinical variables. Methods: Between January 2017 and February 2018, 34 children with newly-diagnosed T1DM and 34 age, gender, and education-matched healthy controls were included. Three dimensional pseudo-continuous ASL perfusion MRI was used to evaluate CBF. A conventional T2WI sequence was added to exclude intracranial disease. Regions with CBF differences between T1DM children and the controls were detected via voxel-wise comparisons in REST software. Associations among the result of neuropsychological test, clinical variables, and CBF values of different brains were investigated by using partial correlation analysis. Results: Compared with the controls, T1DM children show decreased CBF in the left calcarine and postcentral gyrus, and right precentral gyrus. The perfusion in the postcentral gyrus was positively correlated with IQ performance. No significant correlations were found between CBF and HbA1c, blood glucose level before imaging and IQ in other brain regions in T1DM children. Conclusion: There is an abnormal cerebral perfusion in children with newly diagnosed T1DM. The visual and sensorimotor areas are brain areas where perfusion is prone to change at the beginning of T1DM. Our study provided clues for cerebral pathophysiological changes in the initial stage of T1DM.

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Altered Brain Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Patients: A Resting-State fMRI Study

Cited by 42 publications

References 54 publications

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study

Disrupted Regional Cerebral Blood Flow in Children With Newly-Diagnosed Type 1 Diabetes Mellitus: An Arterial Spin Labeling Perfusion Magnetic Resonance Imaging Study

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