Altered brain metabolism in vestibular migraine: Comparison of interictal and ictal findings

Shin, Jung Hwan; Kim, Yu K.; Kim, Hyojung; Kim, Ji-Soo

doi:10.1177/0333102413498940

Cited by 126 publications

(98 citation statements)

References 43 publications

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“…Recently, an 18 F-fluorodeoxy glucose-PET study [11] has been conducted in two patients who underwent a detailed neurotological evaluation, during and between VM attacks. This work, although with the very small sample limitation, first analyzed regional brain metabolism of patients with VM, according to Lempert's criteria [3], in comparison with that of age-matched healthy controls (HC) in each patient.…”

Section: Discussionmentioning

confidence: 99%

Vestibular migraine pathophysiology: insights from structural and functional neuroimaging

et al. 2015

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Vestibular migraine (VM) has been increasingly recognized as a frequent cause of episodic vertigo, affecting up to 1 % of the general population, with female preponderance. Recently, both the Bárány Society and the Migraine Classification Subcommittee of the International Headache Society have proposed original diagnostic criteria for VM, which have been included in the recent edition of the ICHD-3 beta version. VM diagnosis implies that vestibular symptoms are present during a migraine attack, with or without headache, in the absence of objectively demonstrated interictal vestibulopathy. Nevertheless, despite a growing body of literature, there is still an ongoing debate regarding whether VM origin is principally central or peripheral. However, during the past few years, the extensive application of advanced MRI techniques has contributed to significantly improve the understanding VM pathophysiology. Functional and structural abnormalities have been detected in brain areas involved in multisensory vestibular control and central vestibular processing in patients with VM. In this brief review, we will focus on these recent neuroimaging findings.

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Section: Discussionmentioning

confidence: 99%

Vestibular migraine pathophysiology: insights from structural and functional neuroimaging

et al. 2015

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“…Positron emission tomography (PET) studies revealed an increase in metabolism in the temporoparietoinsular areas and bilateral thalami during VM attacks, which indicates that there was an activation of the vestibulothalamocortical pathway [74]. Patients with VM also exhibit significant increases in ipsilateral thalamic activation following vestibular stimulation compared with controls and patients with migraine without aura [75].…”

Section: Pathogenesis Of Vmmentioning

confidence: 99%

Recent Advances in the Understanding of Vestibular Migraine

Sohn

2016

Behavioural Neurology

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Approximately 1% of the general population and 10% of patients with migraine suffer from vestibular migraine (VM). However, this condition remains relatively unknown; therefore, it is often underdiagnosed despite the recent adoption of international diagnostic criteria for VM. The diagnosis of VM is based on the symptoms, degree, frequency, and duration of the vestibular episodes, a history of migraine, the temporal association of migraine symptoms with vestibular episodes in at least 50% of cases, and the exclusion of other causes. Physical examination and laboratory findings are usually normal in patients with VM but can be used to rule out other vestibular disorders with similar symptoms. The pathophysiology of VM remains incompletely understood; however, several mechanisms link the trigeminal system, which is activated during migraine attacks, and the vestibular system. Because few controlled trials have specifically investigated VM, the treatment options for this order are largely the same as those for migraine and include antiemetics for severe acute attacks, pharmacological migraine prophylaxis, and lifestyle changes.

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“…Shin et al [10] studied two VM patients with 18 F-fluorodeoxy glucose (FDG) positron-emission tomography (PET) during and between attacks of VM and correlated imaging findings with neurotological examination. During the attack, both patients demonstrated activation of the bilateral cerebellum and frontal cortices, and deactivation of the bilateral posterior parietal and occipito-temporal areas.…”

Section: Review Of Previous Studiesmentioning

confidence: 99%

A review of recent literature on functional MRI and personal experience in two cases of definite vestibular migraine

et al. 2016

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The pathophysiology of vestibular migraine (VM) is at present poorly understood. Functional magnetic resonance imaging (fMRI), a technique that measures brain activity by detecting changes associated with blood flow oxygenation, has been used to study neural pathways involved in VM pathophysiology. In this study, we summarize results of previous fMRI studies in VM patients, both during and between vertigo attacks. Moreover, we report our experience in two patients with definite VM, who underwent fMRI during a visual stimulation in a vertigo-free period. Compared with 15 matched healthy controls, fMRI demonstrated activation of brain areas related to integration of visual and vestibular cues (increased activation of the paracentral lobule and bilateral inferior parietal lobule and decreased activation of the left superior frontal gyrus, head of the caudate nucleus, left superior temporal gyrus, left parahippocampal gyrus, and right lingual gyrus). Our results partially confirm those of other authors, reporting increased activation of multimodal association brain areas (BA 40, BA 31/5) and decreased activation of occipital regions In addition, we also found a decreased activation of fronto-temporal areas, such as the parahippocampal region, functionally involved in space memory and navigation.

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Altered brain metabolism in vestibular migraine: Comparison of interictal and ictal findings

Cited by 126 publications

References 43 publications

Vestibular migraine pathophysiology: insights from structural and functional neuroimaging

Vestibular migraine pathophysiology: insights from structural and functional neuroimaging

Recent Advances in the Understanding of Vestibular Migraine

A review of recent literature on functional MRI and personal experience in two cases of definite vestibular migraine

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