Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study

Tan, Gang; Dan, Zeng-Renqing; Zhang, Ying; Huang, Xin; Zhong, Yang; Ye, Lin‐Hong; Rong, Rong; Ye, Lei; Zhou, Qiong; Shao, Yi

doi:10.1177/0300060517715340

Cited by 44 publications

(40 citation statements)

References 59 publications

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“… 39 In addition, voxel-wise degree centrality (DC) values of comitant exotropia strabismus patients decreased in the right middle frontal gyrus. 54 Furthermore, Tan et al 22 reported lower ALFF values of the bilateral middle frontal gyrus in subjects with congenital comitant strabismus, and similar ALFF reduction was found in anisometropic amblyopia patients. 55 In support of these preceding reports, we also inspected decreased ALFF values in the left middle frontal gyrus in the SA group, which indicated FEF functional injury in these patients.…”

Section: Discussionmentioning

confidence: 84%

“… 60 Hayakawa et al 58 suggested that the cerebellar posterior vermis was related to saccadic eye movements. Huang et al 61 found the mean diffusivity values in the bilateral cerebellum posterior lobe were significantly decreased in comitant strabismus patients, and Tan et al 54 found DC values of comitant exotropia strabismus patients reduced in the right cerebellum posterior lobe. Moreover, lower ALFF value of strabismus subjects has been observed in the bilateral cerebellum posterior lobe.…”

Section: Discussionmentioning

confidence: 99%

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Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

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ObjectivePrevious studies have demonstrated that strabismus or amblyopia can result in markedly brain function and anatomical alterations. However, the differences in spontaneous brain activities of strabismus with amblyopia (SA) patients still remain unclear. This current study intended to use the amplitude of low-frequency fluctuation (ALFF) technique to investigate the intrinsic brain activity changes in SA subjects.Patients and methodsA total of 16 patients with SA (6 males and 10 females) and 16 healthy controls (HCs; 6 males and 10 females) similarly matched in age, gender, and education status were recruited and examined with the resting-state functional MRI. The spontaneous brain activity changes were investigated using the ALFF technique. The receiver operating characteristic curve was performed to classify the mean ALFF signal values of the SA patients from HCs. The correlations between the ALFF values of distinct brain regions and the clinical manifestations in SA patients were evaluated in terms of the Pearson’s correlation analysis.ResultsCompared with HCs, SA patients had significantly decreased ALFF in the left cerebellum posterior lobe, left middle frontal gyrus, and bilateral thalamus. In contrast, SA patients showed increased ALFF values in the right superior frontal gyrus, right precuneus, left cuneus, and bilateral precentral gyrus. Nonetheless, there was no linear correlation between the mean ALFF values in brain regions and clinical features.ConclusionDiverse brain regions including vision-related and motion-related areas exhibited aberrant intrinsic brain activity patterns, which imply the neuropathologic mechanisms of oculomotor disorder and vision deficit in the SA patients.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Min¹,

Su²,

Shu³

et al. 2018

NDT

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“… 11 The voxel-wise degree centrality in the temporal gyrus was increased in a study of the functional brain activity network. 17 Given that the ILF is not only the major association pathway that links the occipital cortex with the temporal lobe (an indirect pathway is also linked to the frontal lobe), 18 we speculate that this phenomenon might indicate more numerous dense connections or less branching within fiber bundles, representing the underlying neuropathologic mechanism. Increased FA in the IFO was an unexpected finding in our patients with comitant exotropia, which is characterized by integrity of the fiber bundles.…”

Section: Discussionmentioning

confidence: 95%

Analysis of alterations in white matter integrity of adult patients with comitant exotropia

Zeng

2018

J Int Med Res

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ObjectiveThis study was performed to investigate structural abnormalities of the white matter in patients with comitant exotropia using the tract-based spatial statistics (TBSS) method.MethodsDiffusion tensor imaging data from magnetic resonance images of the brain were collected from 20 patients with comitant exotropia and 20 age- and sex-matched healthy controls. The FMRIB Software Library was used to compute the diffusion measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). These measures were obtained using voxel-wise statistics with threshold-free cluster enhancement.ResultsThe FA values in the right inferior fronto-occipital fasciculus (IFO) and right inferior longitudinal fasciculus were significantly higher and the RD values in the bilateral IFO, forceps minor, left anterior corona radiata, and left anterior thalamic radiation were significantly lower in the comitant exotropia group than in the healthy controls. No significant differences in the MD or AD values were found between the two groups.ConclusionsAlterations in FA and RD values may indicate the underlying neuropathologic mechanism of comitant exotropia. The TBSS method can be a useful tool to investigate neuronal tract participation in patients with this disease.

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“…The superior temporal gyrus (STG) locates in the temporal lobe and is responsible for language comprehension,46 auditory processing,47 and visual search 48. Previous studies have reported that STG dysfunction might be associated with a range of diseases, including schizophrenia,49 Alzheimer’s disease,50 adult concomitant exotropia strabismus51 and unilateral acute open-globe injury 52. In our present study, we found that IFCD values in the STG were significantly increased in patients with CU, indicating that CU might be related to abnormal function in the STG.…”

Section: Discussionmentioning

confidence: 99%

<p>Resting-state functional magnetic resonance imaging (fMRI) and functional connectivity density mapping in patients with corneal ulcer</p>

Zhu

Tang

Zhu

et al. 2019

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Purpose To investigate alternations in spontaneous brain activities reflected by functional connectivity density (FCD) in patients with corneal ulcer (CU) using resting-state functional connectivity (rsFC). Methods We recruited 24 patients with CU (12 males, 12 females), and 24 healthy controls (HCs; 12 males, 12 females) matched for age, gender and education status. Functional magnetic resonance imaging examinations were performed on all subjects in a resting state and the following parameters determined: rsFC, long-range FCD (longFCD) and short-range FCD (IFCD). Receiver operating characteristic (ROC) curves were then used to differentiate patients with CU from HCs. Results Compared with HCs, CU patients showed significantly reduced rsFC values in the right cerebellum posterior lobe gyrus, right middle frontal gyrus/inferior frontal gyrus/superior frontal gyrus and left inferior parietal lobule/precuneus. Significantly reduced longFCD values were found in the right hippocampus/inferior temporal gyrus and the left inferior temporal gyrus. Moreover, compared with HCs, IFCD values were significantly reduced in the left inferior temporal gyrus/middle temporal gyrus, left limbic lobe/medial frontal gyrus, and left precuneus/limbic lobe, but were significantly increased in the right insula/superior temporal gyrus, left superior temporal gyrus/inferior frontal gyrus/insula, right superior temporal gyrus/postcentral gyrus, and left precentral gyrus. Conclusions Patients with CU exhibited alterations in spontaneous brain activities in several brain areas. These novel findings may help to reveal the neuropathological mechanisms underlying CU. This study provides a direction for further exploration of underlying neural mechanisms of CU and facilitate the clinical diagnosis and treatment of CU.

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Altered brain network centrality in patients with adult comitant exotropia strabismus: A resting-state fMRI study

Cited by 44 publications

References 59 publications

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Altered spontaneous brain activity patterns in strabismus with amblyopia patients using amplitude of low-frequency fluctuation: a resting-state fMRI study

Analysis of alterations in white matter integrity of adult patients with comitant exotropia

<p>Resting-state functional magnetic resonance imaging (fMRI) and functional connectivity density mapping in patients with corneal ulcer</p>

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