Altered Caffeine Metabolism Is Associated With Recurrent Hypoglycemia in Type 2 Diabetes Mellitus: A UPLC–MS-Based Untargeted Metabolomics Study

Wang, Lijing; Sujie, Ke; Wang, Linxi; Huang, Lijuan; Liqin, Qi; Zhidong, Zhan; Kejun, Wu; Zhang, Mengjun; Li, Xiaoying; Liu, Xiaohong; Liu, Libin

doi:10.3389/fendo.2022.843556

Cited by 5 publications

(3 citation statements)

References 48 publications

(47 reference statements)

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“…Furthermore, it is known that the upregulation of PPARα through FXR stimulates free fatty acids β-oxidation and, consequently, a reduction in VLDL [165]. The decrease in triglycerides associated with the upregulation of O-acylcarnitine suggests an increase in FFA β-oxidation and a consequent improvement in the lipid profile and related metabolic syndromes [166].…”

Section: Caffeine-mechanisms Of Action On Obesitymentioning

confidence: 99%

Metabolic Insights into Caffeine’s Anti-Adipogenic Effects: An Exploration through Intestinal Microbiota Modulation in Obesity

Fortunato,

Pereira,

Oliveira

et al. 2024

IJMS

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Obesity, a chronic condition marked by the excessive accumulation of adipose tissue, not only affects individual well-being but also significantly inflates healthcare costs. The physiological excess of fat manifests as triglyceride (TG) deposition within adipose tissue, with white adipose tissue (WAT) expansion via adipocyte hyperplasia being a key adipogenesis mechanism. As efforts intensify to address this global health crisis, understanding the complex interplay of contributing factors becomes critical for effective public health interventions and improved patient outcomes. In this context, gut microbiota-derived metabolites play an important role in orchestrating obesity modulation. Microbial lipopolysaccharides (LPS), secondary bile acids (BA), short-chain fatty acids (SCFAs), and trimethylamine (TMA) are the main intestinal metabolites in dyslipidemic states. Emerging evidence highlights the microbiota’s substantial role in influencing host metabolism and subsequent health outcomes, presenting new avenues for therapeutic strategies, including polyphenol-based manipulations of these microbial populations. Among various agents, caffeine emerges as a potent modulator of metabolic pathways, exhibiting anti-inflammatory, antioxidant, and obesity-mitigating properties. Notably, caffeine’s anti-adipogenic potential, attributed to the downregulation of key adipogenesis regulators, has been established. Recent findings further indicate that caffeine’s influence on obesity may be mediated through alterations in the gut microbiota and its metabolic byproducts. Therefore, the present review summarizes the anti-adipogenic effect of caffeine in modulating obesity through the intestinal microbiota and its metabolites.

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Section: Caffeine-mechanisms Of Action On Obesitymentioning

confidence: 99%

Metabolic Insights into Caffeine’s Anti-Adipogenic Effects: An Exploration through Intestinal Microbiota Modulation in Obesity

Fortunato,

Pereira,

Oliveira

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…After absorption, caffeine is mainly metabolized in the liver, with several cytochrome P-450(CYP) isoforms (CYP1A2, CYP2E1, CYP2D5-Met, and CYP1A1) being responsible for its primary alterations, generating several biologically active metabolites (i.e., paraxanthine, theobromine, and theophylline) (10).Genetic background partly accounts for the inter-individual variation in caffeine metabolism, whereas metabolic disorders, drinking, and smoking habits also exert an in uence. Obesity mildly modi es caffeine pharmacokinetics (11,12), and altered patterns of caffeine and its main downstream metabolites have been observed in diabetic patients with hypoglycemia (13). Furthermore, alcohol and smoking have been shown to affect caffeine clearance by regulating CYP activity (14,15).…”

Section: Introductionmentioning

confidence: 99%

Relationship between caffeine intake and thyroid function: results from NHANES 2007-2012

Zheng

Zhu

Gui-qing

et al. 2023

Preprint

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Backgrounds: Moderate caffeine intake decreases the risk of metabolic disorders and all-cause mortality, and the mechanism may be related to its ergogenic actions. Thyroid hormones are vital in metabolic homeostasis; however, their associationwith caffeine intake has rarely been explored. Objective: To investigate the association between caffeine intake and thyroid function. Methods: We collected data on demographic background, medical conditions, dietary intake, and thyroid function from National Health and Nutrition Examination Survey (NHANES)2007-2012. Subgroups were classified using two-step cluster analysis, and sex, age, body mass index (BMI), hyperglycemia, hypertension, and cardio-cerebral vascular disease (CVD) were used for clustering. Restrictive cubic spline analysis was employed to investigate potential nonlinear correlations, and multivariable linear regression was used to evaluate the association between caffeine consumption and thyroid function. Results: A total of 2,582 participants were included, and three subgroups with different metabolic features were clustered. In the most metabolically unhealthy group, with the oldest age, highest BMI, and more cases of hypertension, hyperglycemia, and CVD, there was a non-linear relationship between caffeine intake and serum thyroid stimulating hormone (TSH) level. After adjusting for age, sex, race, drinking, smoking, medical conditions, micronutrient and macronutrient intake, caffeine intake less than 9.97 mg/d was positively related to serum TSH (p = 0.035, standardized β = 0.155); however, moderate caffeine consumption (9.97-264.97 mg/d) showed a negative association (p = 0.001, standardized β = - 0.152). Conclusions: Caffeine consumption has a non-linear relationship with serum TSH in people with metabolic disorders, and moderate caffeine intake (9.97~264.97 mg/d) was positively related with serum TSH.

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“…Notably, the genetic background partly accounts for the inter-individual variation in caffeine metabolism, as well as metabolic disorders, drinking, and smoking habits. Obesity mildly modifies caffeine pharmacokinetics [11,12], and altered patterns of caffeine and its main downstream metabolites have been observed in diabetic patients with hypoglycemia [13]. Furthermore, alcohol and smoking have been shown to affect caffeine clearance by regulating CYP activity [14,15].…”

Section: Introductionmentioning

confidence: 99%

Relationship between caffeine intake and thyroid function: results from NHANES 2007–2012

Zheng¹,

Zhu²,

Gui-qing³

et al. 2023

Nutr J

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Background Moderate caffeine intake decreases the risk of metabolic disorders and all-cause mortality, and the mechanism may be related to its ergogenic actions. Thyroid hormones are vital in metabolic homeostasis; however, their association with caffeine intake has rarely been explored. Objective To investigate the association between caffeine intake and thyroid function. Methods We collected data on demographic background, medical conditions, dietary intake, and thyroid function from the National Health and Nutrition Examination Survey (NHANES) 2007–2012. Subgroups were classified using two-step cluster analysis, with sex, age, body mass index (BMI), hyperglycemia, hypertension, and cardio-cerebral vascular disease (CVD) being used for clustering. Restrictive cubic spline analysis was employed to investigate potential nonlinear correlations, and multivariable linear regression was used to evaluate the association between caffeine consumption and thyroid function. Results A total of 2,582 participants were included, and three subgroups with different metabolic features were clustered. In the most metabolically unhealthy group, with the oldest age, highest BMI, and more cases of hypertension, hyperglycemia, and CVD, there was a nonlinear relationship between caffeine intake and serum thyroid stimulating hormone (TSH) level. After adjusting for age, sex, race, drinking, smoking, medical conditions, and micronutrient and macronutrient intake, caffeine intake of less than 9.97 mg/d was positively associated with serum TSH (p = 0.035, standardized β = 0.155); however, moderate caffeine consumption (9.97–264.97 mg/d) indicated a negative association (p = 0.001, standardized β = − 0.152). Conclusions Caffeine consumption had a nonlinear relationship with serum TSH in people with metabolic disorders, and moderate caffeine intake (9.97 ~ 264.97 mg/d) was positively associated with serum TSH.

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Altered Caffeine Metabolism Is Associated With Recurrent Hypoglycemia in Type 2 Diabetes Mellitus: A UPLC–MS-Based Untargeted Metabolomics Study

Cited by 5 publications

References 48 publications

Metabolic Insights into Caffeine’s Anti-Adipogenic Effects: An Exploration through Intestinal Microbiota Modulation in Obesity

Metabolic Insights into Caffeine’s Anti-Adipogenic Effects: An Exploration through Intestinal Microbiota Modulation in Obesity

Relationship between caffeine intake and thyroid function: results from NHANES 2007-2012

Relationship between caffeine intake and thyroid function: results from NHANES 2007–2012

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