Altered CD40 and E‐cadherin expression – putative role in oral lichen planus

Neppelberg, Evelyn; Loro, Lado Lako; Øijordsbakken, Gunnvor; Johannessen, A. C.

doi:10.1111/j.1600-0714.2007.00511.x

Cited by 24 publications

(34 citation statements)

References 46 publications

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“…Furthermore, Langerhans cells are capable of phagocytosis of vaginal apoptotic epithelial cells (71). These findings are of particular interest, as it is thought that apoptotic keratinocytes are present in OLP (9). Transport of antigen from these cells to lymph nodes may induce an immunogenic response to these antigens instead of a tolerizing effect (72).…”

Section: Discussionmentioning

confidence: 99%

“…CD40 is a 45-50 kDa phosphorylated type I integral membrane glycoprotein that belongs to the tumor necrosis factor receptor superfamily, which is expressed on various hematopoietic and non-hematopoietic cells (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). CD40 is involved in several biological functions, such as cell-mediated immunity and cell growth regulation.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies reported that these chemokines are upregulated in oral lichen planus (OLP) and that OLP is characterized by large numbers of activated T-cells localized near the epithelium or infiltrating basal epithelium (7,9).…”

Section: Introductionmentioning

confidence: 99%

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Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus

et al. 2017

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Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease that targets stratified epithelia, including those lining the oral cavity. The intraoral variant of LP (OLP) is associated with interferon (IFN)-γ production by infiltrating T lymphocytes; however, the role of epithelial cells in the etiopathogenesis OLP is not completely understood. There is however a growing body of evidence regarding the involvement of epithelial-derived cytokines, immune receptors, and costimulatory molecules in the pathobiological processes that promote and sustain OLP. In the present study, we used a reverse transcriptase-polymerase chain reaction assay to assess whether CD40-a receptor found mainly on antigen presenting cells-and the costimulatory molecule CD86 were expressed in oral keratinocytes (three strains of primary normal oral keratinocytes and the H357 cell line) in the presence or absence of IFN-γ. To further characterize the involvement of CD40 in OLP, expression and distribution of receptor and ligand (CD40/CD154) in tissues from OLP were evaluated by immunohistochemistry. The present results are the first to show that both CD40 and CD86 are constitutively expressed at low levels in oral keratinocytes and that their expression was enhanced by IFN-γ stimulation. The intensity of CD40 staining in OLP tissues was strong. Taken together, the results strongly suggest that CD40 and CD86 play a role in the pathophysiology of oral inflammatory diseases such as OLP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immune receptors CD40 and CD86 in oral keratinocytes and implications for oral lichen planus

et al. 2017

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“…Santoro (2004) • Aumento de Granzima B, Tia-1 y perforina en LPO respecto a LP cutáneo. Neppelberg (2007) • CD40, CD40L disminuidos.…”

Section: Estudio Clínico Resultadosunclassified

“…Neppelberg y cols 23 (2007) estudiaron la expresión en relación con la apoptosis celular de CD40, CD40 ligando, CD44 y cadherina epitelial. CD40 es una proteína transmembrana perteneciente a la superfamilia del receptor del factor de necrosis tumoral (TNFR), expresada por células con alto potencial proliferativo (queratinocitos, células T, células dendríticas y macrófagos).…”

Section: Mazzarella Y Colsunclassified

Apoptosis y liquen plano oral: Situación actual

Gil¹,

Flores²

2009

Av Odontoestomatol

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RESUMENEl liquen plano oral (LPO) es una enfermedad mucocutánea inflamatoria crónica, con una etiología aún desconocida, de base autoinmune, que suele cursar con manifestaciones orales, con una clínica e histología características y de curso evolutivo benigno, pero susceptible de transformación maligna. En los últimos años se ha investigado la relación entre su patogenia y los mecanismos apoptóticos de destrucción celular. Material y método: Búsqueda bibliográfica en el servidor de la U.S. National Library of Medicine and the National Institutes of Health (Pubmed) con las palabras clave "apoptosis AND oral lichen planus". Discusión: Existen diferentes estudios que evalúan la relación de los diferentes marcadores apoptóticos (TNF-α, bcl-2, Fas, p53, BMP-4, granzima B, MMP…) con la patogenia, evolución, clínica y malignización del LPO. Para la determinación de estos factores se emplean técnicas de anatomía patológica e inmunohistoquímica (TUNEL, PCR,…). Conclusión: no existe consenso en los resultados y las consiguientes conclusiones obtenidas en los diferentes estudios sobre la influencia de cada uno de los marcadores apoptóticos en el desarrollo de las lesiones de LPO. Es necesaria una mayor y más profunda investigación en búsqueda de un factor siempre asociado a las formas clínicas agresivas con mayor tendencia a la malignización.Palabras clave: Liquen plano oral, apoptosis, p53, Bcl-2, queratinocitos. SUMMARYOral lichen planus (OLP) is a mucocutaneous inflammatory chronic disease, with unknown etiology, autoinmune, usually associated with characteristical oral manifestations. Despite it has a benign evolution, is posible to become malign. Lately, relation between the pathogenesis and apoptotic cells destroy has been investigated. Methods: A bibliography survey was carried out with th U.S. National Library of Medicine and the National Institutes of Health (Pubmed) with the keywords "apoptosis AND oral lichen planus". Discussion: Several trials evaluate the relationship among several apoptotic markers (TNF-α, bcl-2, Fas, p53, BMP-4, granzyme B, MMP…) and OLP pathogenesis, evolution, clinic and malignization. These studies employed histology and immunohistochemistry (TUNEL, PCR) Conclusion: Lack of consensus on results and conclusions about the influence of each apoptotic marker in the OLP development. Further investigation is required to obtain an apoptotic marker strongly associated with aggressive clinic and high-risk of malignancy.

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