Altered cerebellar white matter in sensory processing dysfunction is associated with impaired multisensory integration and attention

Narayan, Anisha; Rowe, Mikaela; Palacios, Eva M.; Wren-Jarvis, Jamie; Bourla, Ioanna; Gerdes, Molly; Brandes‐Aitken, Annie; Desai, Shivani S.; Marco, Elysa J.; Mukherjee, Pratik

doi:10.1101/2020.11.11.20230219

Cited by 6 publications

(5 citation statements)

References 48 publications

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“…If the temporal orders between nodes E and L are derived in a global sense (the rectangle in the middle panel of Figure S9-C), a reversed temporal order against the intrinsic one is derived (red timing axis in bottom panel in Figure S9-C). Speculatively, this observation may be related with multisensory integration [69][70] concerning the transmission and integration of different sensory signals, e.g. information from E and L is required in T1∼T3, but L should be activated by E before the propagation from L to T1∼T3 can be started (Figure S9-C).…”

Section: Discussionmentioning

confidence: 99%

Latency structure of BOLD signals within white matter in resting-state fMRI

Bi¹,

Zhou²,

Li³

et al. 2021

Preprint

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Previous studies have demonstrated that BOLD signals in gray matter in resting-state functional MRI (RSfMRI) have variable time lags. We investigated the corresponding variations of signal latencies in white matter within 1393 subjects (both sexes included) from the Brain Genomics Superstruct Project. We divided the dataset into ten equal groups to study both the patterns and reproducibility of latency estimates within white matter. We constructed time delay matrices by computing cross-correlation functions between voxel pairs. Projections of voxel latencies were highly correlated (average Pearson correlation coefficient = 0.89) across the subgroups, confirming the reproducibility and structure of signal lags in white matter. We also applied a clustering analysis to identify functional networks within white matter. Analysis of latencies within and between networks revealed a similar pattern of inter- and intra-network communication to that reported for gray matter. Moreover, a unidirectional path, from inferior to superior regions, of BOLD signal propagation was revealed by higher resolution clustering. The variations of lag structure within white matter are associated with different sensory states (eyes open vs eyes closed, and eyes open with fixation vs. eyes closed). These findings provide additional insight into the character and roles of white matter BOLD sig-nals in brain functions.

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Section: Discussionmentioning

confidence: 99%

Latency structure of BOLD signals within white matter in resting-state fMRI

Bi¹,

Zhou²,

Li³

et al. 2021

Preprint

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“…There is increasing evidence to suggest that the cerebellum plays a role in perceptual processes, such as nociception, visual and auditory processing, and attentional adjustment of perceptual discrimination (Baumann et al, 2015; Breska & Ivry, 2021; Rondi‐Reig et al, 2014). It is even proposed that the white matter integrity of the cerebellum can affect sensory processing (Narayan et al, 2021). Given DEK's potential involvement in myelination, it is possible that DEK expression could be important for maintaining white matter integrity in various brain regions, including the cerebellum.…”

Section: Discussionmentioning

confidence: 99%

In silico gene expression and pathway analysis of DEK in the human brain across the lifespan

Greene

Nguyen

Paranjpe

et al. 2022

Eur J of Neuroscience

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DEK, a chromatin-remodelling phosphoprotein, is associated with various functions and biological pathways in the periphery, including inflammation, oncogenesis, DNA repair, and transcriptional regulation. We recently identified an association between DEK loss and central nervous system diseases, such as Alzheimer's. To understand DEK's potential role in disease, it is critical to characterize DEK in healthy human brain to distinguish between neural DEK expression and function in healthy versus diseased states like dementia.We utilized two public databases, BrainCloud and Human Brain Transcriptome, and analysed DEK mRNA expression across the lifespan in learning and memory relevant brain regions. Since DEK loss induces phenotypes associated with brain ageing (e.g., DNA damage and apoptosis), we hypothesized that neural DEK expression may be highest during foetal development and lower in elderly individuals. In agreement with this hypothesis, DEK was most prominently expressed during foetal development in all queried forebrain areas, relative to other ages. Consistent with its roles in the periphery, pathways related to DEK in the brain were associated with cellular proliferation, DNA replication and repair, apoptosis, and inflammation. We also found novel neural development-relevant pathways (e.g., synaptic transmission, neurite outgrowth, and myelination) to be enriched from genes correlated with DEK expression. These findings suggest that DEK is important for human brain development. Overall, we highlight age-related changes in neural DEK

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“…S9 – C ). Speculatively, this observation may be related with multisensory integration [ 69 , 70 ] concerning the transmission and integration of different sensory signals, e.g. information from E and L is required in T1 ~ T3, but L should be activated by E before the propagation from L to T1 ~ T3 can be started ( Fig.…”

Section: Discussionmentioning

confidence: 99%