Altered circadian dynamics of Per2 after cystathionine-β-synthase and/or cystathionine-γ-lyase pharmacological inhibition in serum-shocked NIH-3T3 cells

Romerowicz-Misielak, Maria; Kozioł, Katarzyna; Nowak, Sławomir; Koziorowski, Marek

doi:10.1016/j.abb.2020.108713

Cited by 1 publication

(1 citation statement)

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“…Interestingly, the folate deficiency which leads to hyperhomocysteinemia, coordinately dampens PER2 and vasopressin circadian rhythms and reduces responsiveness to photic resetting of the liver clock in mice [ 572 ]. Moreover, the pharmacological inhibition or knockdown of cystathionine β-synthase (CBS), which is involved in metabolism of Hcys and its deficiency, leads to hyperhomocysteinemia, significantly increases the amplitude of oscillations and baseline expression of Per2, suggesting an intimate link between the systemic levels of Hcys and circadian rhythms [ 573 ].…”

Section: Introductionmentioning

confidence: 99%

Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

Tabibzadeh¹

2022

Aging and disease

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According to the cell centric hypotheses, the deficits that drive aging occur within cells by age dependent progressive damage to organelles, telomeres, biologic signaling pathways, bioinformational molecules, and by exhaustion of stem cells. Here, we amend these hypotheses and propose an eco-centric model for geroplasticity (aging plasticity including aging reversal). According to this model, youth and aging are plastic and require constant maintenance, and, respectively, engage a host of endogenous rejuvenating (rejuvenins) and gero-inducing [geriatrin] factors. Aging in this model is akin to atrophy that occurs as a result of damage or withdrawal of trophic factors. Rejuvenins maintain and geriatrins adversely impact cellular homeostasis, cell fitness, and proliferation, stem cell pools, damage response and repair. Rejuvenins reduce and geriatrins increase the age-related disorders, inflammatory signaling, and senescence and adjust the epigenetic clock. When viewed through this perspective, aging can be successfully reversed by supplementation with rejuvenins and by reducing the levels of geriatrins.

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Section: Introductionmentioning

confidence: 99%

Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

Tabibzadeh¹

2022

Aging and disease

View full text Add to dashboard Cite

show abstract

Altered circadian dynamics of Per2 after cystathionine-β-synthase and/or cystathionine-γ-lyase pharmacological inhibition in serum-shocked NIH-3T3 cells

Cited by 1 publication

References 43 publications

Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

Resolving Geroplasticity to the Balance of Rejuvenins and Geriatrins

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