Altered Circadian Rhythm of Melatonin Concentrations in Hypocretin-Deficient Men

Donjacour, Cehm Claire; Kalsbeek, Andries; Overeem, Sebastiaan; Lammers, Gert Jan; Pévet, Paul; Bothorel, Béatrice; Pijl, Hanno; Aziz, N. Ahmad

doi:10.3109/07420528.2012.655869

Cited by 9 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, one study examining the pattern of melatonin secretion in narcolepsy with cataplexy found that though mean concentrations were similar to controls, there was a signifi cantly higher percentage of melatonin secreted during the day in those with narcolepsy [ 177 ]. This is consistent with another study demonstrating increased salivary melatonin during the day in narcoleptics with more severe daytime sleepiness [ 178 ].…”

Section: Melatonin and Hypersomniassupporting

confidence: 78%

Sleep Disorders and Melatonin

Dudley

Patel

2013

Impact of Sleep and Sleep Disturbances on Obesity and Cancer

View full text Add to dashboard Cite

Melatonin is an endogenously produced neurohormone that plays a key role in the signaling of daily rhythms and the coordination of these rhythms with the external world. It serves as a marker of darkness and also modulates circadian phase, or timing, through feedback mechanisms on the intrinsic circadian rhythm generated by the suprachiasmatic nucleus. Melatonin and its metabolites can be readily measured in plasma, saliva, and urine. Measurement of melatonin profi les, particularly, the timing of the sharp rise in melatonin levels during the biological night, can be used to assess circadian phase which is useful in the diagnosis of sleep/ circadian pathology as well as determining the optimal timing of treatment. Therapeutically, melatonin can be used to manipulate circadian phase and promote sleep in a circadian rhythm-dependent fashion. Randomized trials have demonstrated that exogenous melatonin can be of benefi t in a number of sleep disease states including delayed sleep phase syndrome, non-24-hour sleep-wake syndrome, jet lag, and insomnia. Keywords

show abstract

Section: Melatonin and Hypersomniassupporting

confidence: 78%

Sleep Disorders and Melatonin

Dudley

Patel

2013

Impact of Sleep and Sleep Disturbances on Obesity and Cancer

View full text Add to dashboard Cite

show abstract

“…The results of this study originate from an extensive, constant routine protocol that was described previously (Donjacour et al ., ,b, ; Fig. ).…”

Section: Methodsmentioning

confidence: 94%

The effects of sodium oxybate on core body and skin temperature regulation in narcolepsy

Heide

Donjacour

Pijl

et al. 2015

Journal of Sleep Research

Self Cite

View full text Add to dashboard Cite

SUMMARYPatients suffering from narcolepsy type 1 show altered skin temperatures, resembling the profile that is related to sleep onset in healthy controls. The aim of the present study is to investigate the effects of sodium oxybate, a widely used drug to treat narcolepsy, on the 24-h profiles of temperature and sleep-wakefulness in patients with narcolepsy and controls. Eight hypocretin-deficient male narcolepsy type 1 patients and eight healthy matched controls underwent temperature measurement of core body and proximal and distal skin twice, and the sleep-wake state for 24 h. After the baseline assessment, 2 9 3 g of sodium oxybate was administered for 5 nights, immediately followed by the second assessment. At baseline, daytime core body temperature and proximal skin temperature were significantly lower in patients with narcolepsy (core: 36.8 AE 0.05°C versus 37.0 AE 0.05°C, F = 8.31, P = 0.01; proximal: 33.4 AE 0.26°C versus 34.3 AE 0.26°C, F = 5.66, P = 0.03). In patients, sodium oxybate administration increased proximal skin temperature during the day (F = 6.46, P = 0.04) to a level similar as in controls, but did not affect core body temperature, distal temperature or distal-proximal temperature gradient. Sodium oxybate administration normalised the predictive value of distal skin temperature and distalproximal temperature gradient for the onset of daytime naps (P < 0.01). In conclusion, sodium oxybate administration resulted in a partial normalisation of the skin temperature profile, by increasing daytime proximal skin temperature, and by strengthening the known relationship between skin temperature and daytime sleep propensity. These changes seem to be related to the clinical improvement induced by sodium oxybate treatment. A causal relationship is not proven.

show abstract

“…Owing to power limitations, we could not draw conclusions concerning the impact of phase-shifted melatonin secretion on sleep, sleepiness and fatigue. Former studies have reported on a delayed secretory melatonin pattern with peaks in the daytime in patients with delayed sleep-phase syndrome (33), whereas another study has observed a relatively higher melatonin secretion during the day in narcoleptic patients (34). Even though secondary narcolepsy is rarely seen, case descriptions of secondary narcolepsy in patients with hypothalamic tumour involvement have been reported (10,13,35,36,37,38).…”

Section: European Journal Of Endocrinologymentioning

confidence: 99%

Sleep–wake and melatonin pattern in craniopharyngioma patients

Pickering

Jennum

Gammeltoft

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To assess the influence of craniopharyngioma or consequent surgery on melatonin secretion, and the association with fatigue, sleepiness, sleep pattern and sleep quality. Design: Cross-sectional study. Methods: A total of 15 craniopharyngioma patients were individually matched to healthy controls. In this study, 24-h salivary melatonin and cortisol were measured. Sleep-wake patterns were characterised by actigraphy and sleep diaries recorded for 2 weeks. Sleepiness, fatigue, sleep quality and general health were assessed by Multidimensional Fatigue Inventory, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Short-Form 36. Results: Patients had increased mental fatigue, daytime dysfunction, sleep latency and lower general health (all, P%0.05), and they tended to have increased daytime sleepiness, general fatigue and impaired sleep quality compared with controls. The degree of hypothalamic injury was associated with an increased BMI and lower mental health (PZ0.01). High BMI was associated with increased daytime sleepiness, daytime dysfunction, mental fatigue and lower mental health (all, P%0.01). Low midnight melatonin was associated with reduced sleep time and efficiency (P%0.03) and a tendency for increased sleepiness, impaired sleep quality and physical health. Midnight melatonin remained independently related to sleep time after adjustment for cortisol. Three different patterns of melatonin profiles were observed; normal (nZ6), absent midnight peak (nZ6) and phase-shifted peak (nZ2). Only patients with absent midnight peak had impaired sleep quality, increased daytime sleepiness and general and mental fatigue. Conclusion: Craniopharyngioma patients present with changes in circadian pattern and daytime symptoms, which may be due to the influence of the craniopharyngioma or its treatment on the hypothalamic circadian and sleep regulatory nuclei.

show abstract

Altered Circadian Rhythm of Melatonin Concentrations in Hypocretin-Deficient Men

Cited by 9 publications

References 25 publications

Sleep Disorders and Melatonin

Sleep Disorders and Melatonin

The effects of sodium oxybate on core body and skin temperature regulation in narcolepsy

Sleep–wake and melatonin pattern in craniopharyngioma patients

Contact Info

Product

Resources

About