Altered collagen synthesis in fascia transversalis of patients with inguinal hernia

Klinge, U.; Zheng, Huang; Y., Z.; Bhardwaj, R.; Klosterhalfen, B.; Schumpelick, Volker

doi:10.1007/bf01194422

Cited by 37 publications

(15 citation statements)

References 20 publications

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“…The observed ratios are those usually found in normal connective tissues. Our results are in contradiction with those of Klinge et al [18], who found a reduction of the collagen I/III ratio, due to an increased amount of collagen type III in the hernia fascias, and surprisingly a complete absence of α 2 (I) chains, while these chains clearly exist in our study and are present in a normal ratio. The patterns obtained by Western blot used in their study were heavily loaded, influencing therefore their quantitative interpretation.…”

Section: Discussioncontrasting

confidence: 57%

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Biochemical Study of Collagen in Adult Groin Hernias

Pans¹,

Albert²,

Lapière³

et al. 2001

Journal of Surgical Research

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Background. Previous works have suggested that a defect in collagen fiber structure may play a role in inguinal hernia formation. These studies focused mainly on the rectus sheath or the skin, while only few reports dealt with the transversalis fascia. According to these findings and to our previous biomechanical and histological studies suggesting that a connective tissue pathology could play a role in the genesis of groin hernias, we performed a biochemical investigation of the collagen in the transversalis fascia and rectus sheath.

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Section: Discussioncontrasting

confidence: 57%

“…Up to now, there are very few biochemical studies focusing on the transversalis fascia [9,18]. However, its study is fundamental to explore the mechanisms leading to inguinal herniation, because its disruption in the weak inguinal area is responsible for groin hernias.…”

Section: Discussionmentioning

confidence: 99%

Biochemical Study of Collagen in Adult Groin Hernias

Pans¹,

Albert²,

Lapière³

et al. 2001

Journal of Surgical Research

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“…Se estudiaron muestras de piel por ser el principal efector del colágeno y de fibras elásticas, además por tener una composición colágena con predominio de colágeno tipo I al igual que la fascia transversalis de la pared posterior del conducto inguinal, que es el plano de tejido que falla en una hernia inguinal 11 . Se consideró como control muestras de piel de pacientes con apendicitis aguda por ser una patología frecuente que facilitó la toma de muestra, por otro lado, es piel muy próxima a la región inguinal e histológicamente la piel de la superficie ventral del organismo es similar sin variaciones regionales.…”

Section: Discussionunclassified

Estudio de fibras colágenas y elásticas del tejido conjuntivo de pacientes con y sin hernia inguinal primaria

M¹,

O²,

D³

et al. 2003

Rev. méd. Chile

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“…Other authors showed changes in the proportions of collagen types I and III in inguinal hernia patients (4,11) . KLINGE et al (10) published pieces of work in which they show changes in the connective tissue of inguinal hernia patients by measuring the proportion of collagen type I and III using immunohistochemistry, western blot and protein electrophoresis.…”

Section: Discussionmentioning

confidence: 99%

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Meyer¹,

Berger²,

Monteiro³

et al. 2007

Arq. Gastroenterol.

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-Background -Inguinal hernia is the second most common surgical case in our field. The anatomical factors alone are not enough to explain the inguinal hernia. Studies show changes in the proportion and quantity of collagen fibers in the developing of inguinal hernia. The greater production of collagen type III compared to the type I could justify the thinning of the fascia transversalis and its weakness. Aim -To determine the quantitative and qualitative changes of collagen in the fascia transversalis in inguinal hernia patients and compare them to findings from corpses without inguinal hernia. Method -Prospective case-control study based on the biopsy of fascia transversalis of 27 patients and 24 corpses. The technique used was hematoxylin-eosin and picrosirius colorimetry. Results -The medium percent area of collagen (types I + III) and collagen type I, in both groups, show no statistic difference. The quantity of collagen type III was greater in the patients. Patients classified with Nyhus IIIa presented greater quantity of collagen type III. Conclusion -There is no significant difference in the quantity of collagen in the fascia transversalis of patients compared to the controls. An increase in the quantity of collagen type III was found in patients with inguinal hernia and a greater quantity in those patients classified with Nyhus IIIa. HEADINGS -Hernia, inguinal. Fascia. Collagen.

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Altered collagen synthesis in fascia transversalis of patients with inguinal hernia

Cited by 37 publications

References 20 publications

Biochemical Study of Collagen in Adult Groin Hernias

Biochemical Study of Collagen in Adult Groin Hernias

Estudio de fibras colágenas y elásticas del tejido conjuntivo de pacientes con y sin hernia inguinal primaria

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

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